---
title: Steadier brain pulses reduce tremor
nct_id: NCT06742450
phase: NA
status: RECRUITING
sponsor: Xuanwu Hospital, Beijing
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06742450"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06742450"
last_fetched: "2026-05-10T14:02:09.216Z"
source: "Parkinson's Pathways (curated)"
---
# Steadier brain pulses reduce tremor

**Goal (in five words):** Steadier brain pulses reduce tremor

**Official Title:** Prospective Study of Constant Current Versus Constant Voltage Deep Brain Stimulation in Patients with Parkinson's Disease

**Trial ID:** [NCT06742450](https://clinicaltrials.gov/study/NCT06742450)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Xuanwu Hospital, Beijing
- **Target Enrollment:** 180 participants
- **Start Date:** 2024-01-27
- **Completion Date:** 2026-03-31
- **Conditions:** Parkinson's Disease (PD)
- **Interventions:** Constant current (CC) subthalamic nucleus deep brain stimulation, Constant voltage (CV) subthalamic nucleus deep brain stimulation
- **Intervention Types:** OTHER

## Summary For Families

They're testing whether delivering stimulation as constant current or constant voltage at the subthalamic nucleus gives steadier, more effective control of motor symptoms with fewer side effects. The approach uses bilateral STN-DBS with either constant current, which keeps the electrical current steady despite changes in tissue impedance, or constant voltage, which holds voltage steady so the actual current can vary; DBS sends pulses to normalize abnormal STN activity, improving tremor, stiffness, and slowness, and often lets people reduce or smooth out levodopa dosing. The trial seeks adults 18 to 75 with idiopathic Parkinson's who already have bilateral STN-DBS electrodes implanted but not yet powered on. People with dementia, major medical problems, epilepsy, pregnancy, severely misplaced electrodes, or inability to consent or follow up are excluded.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Patients with idiopathic Parkinson's disease
* Aged 18 to 75, no limited sex
* After bilateral STN-DBS, yet not powered on

Exclusion Criteria:

* Mental disorders or dementia
* Pregnant, lactating women or women who are unable to take effective measures to prevent pregnancy
* Serious health conditions, such as tumors, liver or kidney diseases, etc.
* Epilepsy or other seizure disorders
* Patients with severely deviated electrode placement
* Patients who were unable to voluntarily sign an informed consent form
* Patients who did not agree to cooperate with follow-up
```

## Locations (1)

- Xuanwu Hospital of Capital Medical University, Beijing, China _(39.9075, 116.3972)_
  - Shanshan Mei — (CONTACT) — +86 13426263236 — sophy33@163.com

## Central Contacts

- Shanshan Mei — (CONTACT) — +86 13426263236 — sophy33@163.com

---

*Canonical: https://parkinsonspathways.com/trial/NCT06742450*  
*HTML version: https://parkinsonspathways.com/trial/NCT06742450*  
*Source data: https://clinicaltrials.gov/study/NCT06742450*