---
title: Reduce depression anxiety and stress
nct_id: NCT06821230
phase: NA
status: RECRUITING
sponsor: The University of Hong Kong
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06821230"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06821230"
last_fetched: "2026-05-10T14:03:55.955Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce depression anxiety and stress

**Goal (in five words):** Reduce depression anxiety and stress

**Official Title:** Enhancing Psychological Wellbeing and the Patient-caregiver Relationship Through Dyadic Mindfulness: A Randomized Controlled Trial in People With Parkinson's Disease and Their Caregivers

**Trial ID:** [NCT06821230](https://clinicaltrials.gov/study/NCT06821230)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** The University of Hong Kong
- **Target Enrollment:** 200 participants
- **Start Date:** 2025-02-11
- **Completion Date:** 2027-06-30
- **Conditions:** Mindfulness, Caregivers, Movement Disorders, Neurodegenerative Disease, Dyadic Intervention, Psychosocial Health, Parkinsons Disease
- **Interventions:** Dyadic mindfulness
- **Intervention Types:** BEHAVIORAL

## Summary For Families

Aims to boost psychological wellbeing and strengthen the patient-caregiver relationship for people with mild to moderate Parkinson's who are experiencing at least mild depression, anxiety, or stress. It offers a dyadic mindfulness program where the person with PD and their primary caregiver learn guided attention, breathing, and emotion-regulation practices together to reduce stress and low mood, improve communication and empathy, and provide coping tools that complement medications rather than replace them. Looking for Cantonese-speaking patient-caregiver pairs, with patients aged 50 to 80, Hoehn and Yahr stage I to III, and at least one DASS-21 threshold met (depression ≥10, anxiety ≥8, or stress ≥15). Excludes pairs already doing regular supervised mind-body practice more than twice weekly, those with acute psychosis, significant cognitive impairment, current participation in other trials, or major hearing/vision problems that would limit participation.

## Eligibility

- **Minimum age:** 50 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria of PwPD:

* Chinese patients with idiopathic mild-moderate PD (as indicated by the Hoehn and Yahr Scale stages I-III: those with unilateral/bilateral symptoms, with/without postural instability who are able to walk/stand unassisted)
* Aged 50-80
* Experience at least mild negative emotions (as indicated by the 21-item Depression, Anxiety and Stress Scale \[DASS21\] score of Depression subscale ≥10, Anxiety subscale ≥8, or Stress subscale ≥15)

Inclusion Criteria of caregivers of PwPD:

\- Self-identified as the primary caregivers of their patient

Both need to be able to communicate in Cantonese and provide written consent.

Exclusion Criteria:

* Engage in regular supervised mind-body practices such as Tai Chi, yoga, or other forms of mindfulness training (\>2 times per week)
* Have a pre-existing acute psychotic disease
* Currently participating in any other behavioral or pharmacological trial
* Have significant cognitive impairment, as indicated by an Abbreviated Mental Test score≤ 6
* Have other contraindications that may limit their full participation (e.g., severe hearing/vision impairment)
```

## Locations (1)

- School of Nursing, The University of Hong Kong, Hong Kong, Hong Kong _(22.2783, 114.1747)_
  - Jojo Yan Yan Kwok — (CONTACT) — +852 39176644 — jojoyyk@hku.hk

## Central Contacts

- Jojo Yan Yan Kwok — (CONTACT) — 852 39176644 — jojoyyk@hku.hk

---

*Canonical: https://parkinsonspathways.com/trial/NCT06821230*  
*HTML version: https://parkinsonspathways.com/trial/NCT06821230*  
*Source data: https://clinicaltrials.gov/study/NCT06821230*