---
title: Find early tests for Parkinson
nct_id: NCT06846658
status: RECRUITING
sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06846658"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06846658"
last_fetched: "2026-05-10T14:07:24.845Z"
source: "Parkinson's Pathways (curated)"
---
# Find early tests for Parkinson

**Goal (in five words):** Find early tests for Parkinson

**Official Title:** Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease

**Trial ID:** [NCT06846658](https://clinicaltrials.gov/study/NCT06846658)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- **Target Enrollment:** 180 participants
- **Start Date:** 2023-10-03
- **Completion Date:** 2026-04
- **Conditions:** Parkinson Disease, MSA - Multiple System Atrophy, Lewy Body Dementia (LBD), Neurodegenerative Disease, Healthy Subjects (HS)

## Summary For Families

The goal is to find early biological signs that can distinguish Parkinson's disease, atypical parkinsonisms like multiple system atrophy, and Lewy body dementia from each other and from healthy aging. Researchers collect samples from the olfactory mucosa (the smell-related nasal tissue), blood and urine, then analyze them for molecular biomarkers such as misfolded proteins like alpha-synuclein and other inflammatory or metabolic signatures that might appear early in disease. About 180 people are being enrolled, including adults with PD, MSA, DLB or other neurodegenerative movement disorders, plus healthy volunteers; the public listing does not specify an age limit.

## Eligibility

- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* PD (Postuma et al., 2015), MSA (Palma et al., 2018), DLB (McKeith et al., 2017), OND including acquired and hereditary ataxic syndrome with known etiology, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease.

Exclusion Criteria:

* na
```

## Locations (3)

- Consorzio Interuniversitario Risonanze Magnetiche Metallo Proteine (CIRMMP), Sesto Fiorentino, FI, Italy _(43.8319, 11.1992)_
  - Linda Cerofolini, PHD — (CONTACT) — (+39) 3473555936 — fragai@cerm.unifi.it
- IRCCS Centro San Giovanni di Dio, Brescia, Italy _(45.5356, 10.2147)_
  - Claudia Saradeno, PHD — (CONTACT) — (+39) 0303501328 — daniela.sarnataro1@gmail.com
- Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy _(42.7824, 12.5984)_
  - Fabio Moda, PHD — (CONTACT) — + 39 02.2394 — fabio.moda@istituto-besta.it
  - Arianna Ciullini, PHD — (CONTACT) — 0039.02.2394

---

*Canonical: https://parkinsonspathways.com/trial/NCT06846658*  
*HTML version: https://parkinsonspathways.com/trial/NCT06846658*  
*Source data: https://clinicaltrials.gov/study/NCT06846658*