---
title: Reduce early Parkinsons motor symptoms
nct_id: NCT06874803
phase: NA
status: RECRUITING
sponsor: Jiani Wu
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06874803"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06874803"
last_fetched: "2026-05-10T14:03:38.316Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce early Parkinsons motor symptoms

**Goal (in five words):** Reduce early Parkinsons motor symptoms

**Official Title:** Effect of "Qi-Tonifying, Yang-Warming, and Water-Resolving" Acupuncture and Moxibustion for Motor Symptom Improvement in Early Parkinson's Disease (WARMED): A Randomized Controlled Trial

**Trial ID:** [NCT06874803](https://clinicaltrials.gov/study/NCT06874803)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Jiani Wu
- **Target Enrollment:** 60 participants
- **Start Date:** 2024-08-01
- **Completion Date:** 2025-08-31
- **Conditions:** Parkinson's Disease (PD)
- **Interventions:** Acupuncture and Moxibustion (AM), Sham Acupuncture and Moxibustion (Sham-AM)
- **Intervention Types:** PROCEDURE

## Summary For Families

It tests whether a traditional acupuncture plus moxibustion protocol that aims to "tonify qi, warm yang, and resolve water" can improve motor symptoms in people with early, mild-to-moderate Parkinson's. The treatment uses needles at specific points together with localized heat from burning mugwort to stimulate nerves and tissues, and investigators think that sensory stimulation may alter brain and spinal cord signaling, muscle control, or local inflammation; they compare real treatment to a sham procedure to see if effects are specific. Because it is non-drug, it would be used alongside usual Parkinson medications like levodopa rather than replacing them. Enrollment is for people aged 30 to 80 with PD by the 2016 Chinese criteria and Hoehn-Yahr stage under 3, excluding Parkinson-plus syndromes, prior DBS, severe medical or psychiatric conditions, bleeding disorders, recent acupuncture, pregnancy, or recent trial participation.

## Eligibility

- **Minimum age:** 30 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

Participants must meet all of the following criteria:

1\. Diagnosed with Parkinson's disease (PD) according to the 2016 Chinese 2. Diagnostic Criteria for Parkinson's Disease.

3\. Hoehn-Yahr stage \<3 (mild to moderate PD). 4. Age between 30 and 80 years (inclusive). 5. Signed informed consent indicating voluntary participation.

Exclusion Criteria:

Participants meeting any of the following criteria will be excluded:

1. Diagnosed with Parkinson-plus syndromes or other secondary parkinsonism.
2. Prior history of deep brain stimulation (DBS) surgery.
3. Severe cerebrovascular disease, brain trauma, or history of craniotomy.
4. Severe dementia or psychiatric disorders that prevent cooperation with study procedures.
5. Severe coagulation disorders.
6. Presence of severe systemic organ dysfunction (cardiac, pulmonary, hepatic, renal, endocrine, or metabolic disorders).
7. Pregnant or breastfeeding women.
8. History of allergic reaction to acupuncture or moxibustion.
9. Prior treatment with acupuncture or moxibustion within the past three months.
10. Participation in another clinical trial within the past three months.
```

## Locations (1)

- Guang'anmen Hospita, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China _(39.9075, 116.3972)_
  - Jiaming Cui — (CONTACT) — 86+18340077036 — Jiaming.cui@foxmail.com

## Central Contacts

- Yu Liu, MD — (CONTACT) — 8572650199 — yliu133@mgh.harvard.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT06874803*  
*HTML version: https://parkinsonspathways.com/trial/NCT06874803*  
*Source data: https://clinicaltrials.gov/study/NCT06874803*