---
title: Lower brain inflammation using exercise
nct_id: NCT06977204
status: RECRUITING
sponsor: "IRCCS National Neurological Institute \"C. Mondino\" Foundation"
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06977204"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06977204"
last_fetched: "2026-05-10T14:05:21.946Z"
source: "Parkinson's Pathways (curated)"
---
# Lower brain inflammation using exercise

**Goal (in five words):** Lower brain inflammation using exercise

**Official Title:** Role of Physical Activity on Neuroinflammation in Parkinson's Disease

**Trial ID:** [NCT06977204](https://clinicaltrials.gov/study/NCT06977204)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** IRCCS National Neurological Institute "C. Mondino" Foundation
- **Target Enrollment:** 40 participants
- **Start Date:** 2023-01-01
- **Completion Date:** 2025-12-31
- **Conditions:** Parkinson Disease, Physical Inactivity, Physical Disability

## Summary For Families

They want to find out whether higher levels of physical activity can lower neuroinflammation that may drive symptom progression and disability in Parkinson's. The study watches how people move in daily life and relates activity to biological signs of inflammation and protective brain factors, since exercise is thought to reduce pro‑inflammatory cytokines and boost neurotrophic support like BDNF. Looking for adults aged 40 to 80 with Parkinson's at Hoehn and Yahr stages 1 to 3. People with dementia, severe depression, deep brain stimulation implants or Duodopa therapy, BMI 30 or higher, active smokers, recent infections, or taking antioxidants such as N‑acetylcysteine are excluded.

## Eligibility

- **Minimum age:** 40 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Subjects of both sexes, aged between 40 and 80 years (extremes included)
* Diagnosis of Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society
* Hoehn \& Yahr between 1 and 3

Exclusion Criteria:

* Concomitant diagnosis of other neurological diseases
* Presence of confirmed cognitive decline (MMSE \< 24)
* Presence of depression with (BDI \> 40)
* Patients with deep brain stimulation implant or undergoing DuoDopa therapy
* Presence of significant diseases affecting the musculoskeletal system
* Presence of internal medicine conditions, considered clinically significant by the investigator
* Acute or recent infections
* Body Mass Index (BMI) \>= 30
* Active smoking behavior
* Ongoing treatment with N-acetylcysteine or anti-oxidants
* Pregnancy or lactation
```

## Locations (1)

- IRCCS Mondino Foundation, Pavia, Pavia, Italy _(45.1921, 9.1592)_
  - Roberto De Icco — (CONTACT) — +390382380425 — roberto.deicco@mondino.it

## Central Contacts

- Roberto De Icco — (CONTACT) — +390382380425 — roberto.deicco@mondino.it
- Cinzia Fattore — (CONTACT) — +390382380385 — cinzia.fattore@mondino.it

---

*Canonical: https://parkinsonspathways.com/trial/NCT06977204*  
*HTML version: https://parkinsonspathways.com/trial/NCT06977204*  
*Source data: https://clinicaltrials.gov/study/NCT06977204*