---
title: Timed stimulation reduces hand tremor
nct_id: NCT06993571
phase: NA
status: RECRUITING
sponsor: Universitätsklinikum Hamburg-Eppendorf
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT06993571"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT06993571"
last_fetched: "2026-05-10T14:06:32.916Z"
source: "Parkinson's Pathways (curated)"
---
# Timed stimulation reduces hand tremor

**Goal (in five words):** Timed stimulation reduces hand tremor

**Official Title:** Closed-loop Phase-adaptive Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Activity in the Cerebello-thalamo-cortical Network to Reduce Parkinson's Disease Tremor

**Trial ID:** [NCT06993571](https://clinicaltrials.gov/study/NCT06993571)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Universitätsklinikum Hamburg-Eppendorf
- **Target Enrollment:** 10 participants
- **Start Date:** 2025-04-16
- **Completion Date:** 2026-09-30
- **Conditions:** Parkinson's Disease (PD), Tremor
- **Interventions:** Active-tACS, Sham-tACS, Unlocked-tACS
- **Intervention Types:** DEVICE

## Summary For Families

The goal is to reduce moderate to severe hand tremor in Parkinson's by changing activity in the cerebello-thalamo-cortical network that helps generate tremor rhythms. The approach uses noninvasive transcranial alternating current stimulation over the cerebellum, delivering weak electrical currents timed to a person’s tremor in a closed-loop, phase-adaptive way to disrupt the abnormal rhythmic brain activity that drives tremor, and because it is non-drug it can be given alongside usual medications like levodopa. Participants may be randomized to active phase-locked tACS, sham tACS, or unlocked tACS that is not phase-locked, so researchers can test whether syncing stimulation to tremor timing matters. The trial is looking for adults 18 and older with a UK Brain Bank diagnosis of Parkinson's and moderate to severe hand tremor who can consent, while excluding people with pacemakers or metal implants, other major neurological or psychiatric disorders, or pregnancy.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Clinical diagnosis of Parkinson's disease based on UK Brain Bank criteria
* Patient exhibiting moderate to severe hand tremor
* Provision written informed consent by the patient

Exclusion Criteria:

* History of other neurological disorders such as vascular malformations, ischemic or haemorrhagic stroke, cerebral neoplasia, epilepsy, or major psychiatric illness
* Existence of heart pacemaker or metal implants in the body
* Pregnancy
```

## Locations (1)

- Universitätsklinikum Hamburg-Eppendorf, Hamburg, Free and Hanseatic City of Hamburg, Germany _(53.5507, 9.9930)_
  - Simone Zittel, Dr. med. — (CONTACT) — +49 40 7410 53770 — s.zittel-dirks@uke.de
  - Fatemeh Sadeghi, Dr. — (SUB_INVESTIGATOR)

## Central Contacts

- Simone Zittel, Dr. med. — (CONTACT) — +49 40 7410 53770 — s.zittel-dirks@uke.de

---

*Canonical: https://parkinsonspathways.com/trial/NCT06993571*  
*HTML version: https://parkinsonspathways.com/trial/NCT06993571*  
*Source data: https://clinicaltrials.gov/study/NCT06993571*