---
title: Reduce forward and sideways leaning
nct_id: NCT07010328
phase: NA
status: RECRUITING
sponsor: "IRCCS National Neurological Institute \"C. Mondino\" Foundation"
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07010328"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07010328"
last_fetched: "2026-05-10T14:08:24.316Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce forward and sideways leaning

**Goal (in five words):** Reduce forward and sideways leaning

**Official Title:** Efficacy of Integrating Artificial Intelligence Solutions in Rehabilitation in Postural Trunk Disorders in Parkinson's Disease.

**Trial ID:** [NCT07010328](https://clinicaltrials.gov/study/NCT07010328)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** IRCCS National Neurological Institute "C. Mondino" Foundation
- **Target Enrollment:** 20 participants
- **Start Date:** 2024-10-01
- **Completion Date:** 2028-01
- **Conditions:** Parkinson Disease, Physical Inactivity, Physical Disability, Pisa Syndrome
- **Interventions:** Neurorehabilitation, AI-based home rehabilitation for postural disorders
- **Intervention Types:** PROCEDURE, DEVICE

## Summary For Families

The goal is to reduce abnormal forward or sideways bending of the trunk, namely camptocormia and Pisa syndrome, to improve posture, balance and daily function in people with Parkinson's. The approach uses an AI-guided home neurorehabilitation program that tracks trunk angles with sensors or camera-based analysis, gives real-time feedback, and personalizes strengthening, stretching and posture-training exercises, used alongside usual Parkinson's medications like levodopa rather than replacing them. The trial is looking for adults 18 and older with Parkinson's at Hoehn and Yahr stage I to III who have camptocormia (≥30°) or Pisa syndrome (≥10°) and an MMSE over 23, excluding those with atypical parkinsonism, prior spinal surgery or major spinal disease, other neurological conditions, or severe dyskinesias.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Age above 18 years
* Diagnosis of Parkinson's disease according to MDS criteria
* Hoehn and Yahr stage ≤ III
* Clinical diagnosis of camptocormia (presence of an anterior axial trunk flexion of at least 30°), or of Pisa Syndrome (presence of a lateral trunk flexion of at least 10°) at the time of enrollment (T0)
* Mini-Mental State Examination (MMSE) score \> 23

Exclusion Criteria:

* Atypical parkinsonian syndromes
* History of spinal surgery
* Previous vertebral trauma
* Current or past spinal tumors or infections
* Idiopathic scoliosis
* Ankylosing spondylitis
* Spinal canal stenosis
* Other neurological conditions
* Severe dyskinesias
```

## Locations (1)

- IRCCS Mondino Foundation, Pavullo nel Frignano, Pavia, Italy _(44.3335, 10.8354)_
  - Roberto De Icco — (CONTACT) — +390382380479 — roberto.deicco@mondino.it

## Central Contacts

- Roberto De Icco — (CONTACT) — +390382380425 — roberto.deicco@mondino.it
- Cinzia Fattore — (CONTACT) — +390382380385 — cinzia.fattore@mondino.it

---

*Canonical: https://parkinsonspathways.com/trial/NCT07010328*  
*HTML version: https://parkinsonspathways.com/trial/NCT07010328*  
*Source data: https://clinicaltrials.gov/study/NCT07010328*