---
title: Improve ability to stop actions
nct_id: NCT07022522
phase: NA
status: RECRUITING
sponsor: Beijing Tiantan Hospital
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07022522"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07022522"
last_fetched: "2026-05-10T14:04:58.344Z"
source: "Parkinson's Pathways (curated)"
---
# Improve ability to stop actions

**Goal (in five words):** Improve ability to stop actions

**Official Title:** Frequency-dependent Modulation of Inhibitory Control Via Subthalamic Nucleus Subregional Stimulation in Parkinson's Disease

**Trial ID:** [NCT07022522](https://clinicaltrials.gov/study/NCT07022522)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Beijing Tiantan Hospital
- **Target Enrollment:** 20 participants
- **Start Date:** 2024-10-01
- **Completion Date:** 2026-02-01
- **Conditions:** Parkinson Disease, Deep Brain Stimulation
- **Interventions:** 5Hz stimulation on the STN motor subregion, 5Hz stimulation on the STN associative subregion, 130Hz stimulation on the STN motor subregion, 130Hz stimulation on the STN associative subregion, No stimulation
- **Intervention Types:** DEVICE

## Summary For Families

The goal is to learn how changing the frequency and exact spot of deep brain stimulation in the subthalamic nucleus affects inhibitory control, meaning the ability to stop or suppress actions that can be harder with Parkinson's. Researchers will apply brief electrical pulses to either the STN motor or associative subregion at low frequency (5 Hz) or high frequency (130 Hz), or leave stimulation off, and compare how those settings change stopping ability; high-frequency STN stimulation generally suppresses abnormal motor firing, while low-frequency pulses can recruit different circuits that may alter cognitive control and impulsivity. The trial is looking for people 40 to 80 years old with idiopathic Parkinson's who meet indications for DBS surgery, excluding those with major psychiatric illness or dementia, significant post-DBS complications, or sensory problems that would affect the cognitive tests.

## Eligibility

- **Minimum age:** 40 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

1. Age 40-80 years old;
2. Diagnosed with idiopathic Parkinson's disease;
3. Meeting the indications for DBS surgery.

Exclusion Criteria:

1. Patient declined to participate in the study;
2. Presence of significant post-DBS complications (e.g., intracranial hemorrhage, cerebral edema, electrode misplacement);
3. Significant psychiatric disorders or dementia (MMSE score \<20 for uneducated; \<23 for 1-6 years education; \<27 for ≥7 years education);
4. Visual or auditory impairment affecting cognitive task performance
5. History of conditions potentially impairing cognitive function.
```

## Locations (1)

- Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China _(39.9075, 116.3972)_
  - Jianguo Zhang — (CONTACT) — +86 13601294613 — zjguo73@126.com

## Central Contacts

- Hutao Xie — (CONTACT) — +8618756921517 — xieht0123@163.com

---

*Canonical: https://parkinsonspathways.com/trial/NCT07022522*  
*HTML version: https://parkinsonspathways.com/trial/NCT07022522*  
*Source data: https://clinicaltrials.gov/study/NCT07022522*