---
title: Predict Parkinson progression using neuroimaging
nct_id: NCT07024875
status: RECRUITING
sponsor: Washington University School of Medicine
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07024875"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07024875"
last_fetched: "2026-05-10T14:05:30.616Z"
source: "Parkinson's Pathways (curated)"
---
# Predict Parkinson progression using neuroimaging

**Goal (in five words):** Predict Parkinson progression using neuroimaging

**Official Title:** Precision Neuroimaging of Parkinson's Disease

**Trial ID:** [NCT07024875](https://clinicaltrials.gov/study/NCT07024875)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Washington University School of Medicine
- **Target Enrollment:** 120 participants
- **Start Date:** 2025-08-01
- **Completion Date:** 2031-01
- **Conditions:** Parkinsons Disease (PD)

## Summary For Families

The goal is to use high-precision MRI to identify brain markers that track Parkinson's progression and link specific brain changes to motor and cognitive symptoms, so diagnosis and care can be more personalized. The approach is non-invasive advanced neuroimaging, using structural and functional MRI to map brain anatomy and activity patterns; the scans do not change your medications or interact with levodopa, they just let researchers see how brain circuits relate to symptoms. They are enrolling adults 50 and older with a clinical diagnosis of Parkinson's who do not meet criteria for dementia, plus healthy volunteers with normal cognition and no first-degree relatives with PD, and they exclude people with other neurological or serious medical or psychiatric conditions, major head injury, or MRI contraindications like metal implants or claustrophobia.

## Eligibility

- **Minimum age:** 40 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Must meet specific health and cognitive criteria depending on the group. For PD participants
* Clinical diagnosis of Parkinson's Disease
* Must not meet dementia criteria For Healthy Control Participants
* Normal or benign neurological exam
* Normal cognition
* No first-degree relatives with Parkinson's Disease

Exclusion Criteria:

1. Neurological Disorders (other than PD)

   \- Any other neurological condition
2. Significant Head Injury

   * Head injury with loss of consciousness \>5 minutes
   * Or any neurological sequelae
3. Psychiatric Disorders

   * Schizophrenia
   * Bipolar Disorder
   * Epilepsy
4. Serious Medical Conditions

   * End-stage organ failure
   * Ongoing cancer treatment
5. Cognitive Impairment

   * Diagnosis of dementia
   * MMSE score \<24 or MoCA score \<21
6. MRI contraindications

   * Metal implants
   * claustrophobia
   * Weight over 300 lbs (due to weight restrictions of the MRI scanner)
```

## Locations (1)

- East Imaging Building, St Louis, Missouri, United States _(38.6273, -90.1979)_

## Central Contacts

- Danny Bower — (CONTACT) — 314-273-4429 — bower@wustl.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT07024875*  
*HTML version: https://parkinsonspathways.com/trial/NCT07024875*  
*Source data: https://clinicaltrials.gov/study/NCT07024875*