---
title: New medication slows early progression
nct_id: NCT07174310
phase: PHASE3
status: RECRUITING
sponsor: Hoffmann-La Roche
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07174310"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07174310"
last_fetched: "2026-05-10T14:06:25.016Z"
source: "Parkinson's Pathways (curated)"
---
# New medication slows early progression

**Goal (in five words):** New medication slows early progression

**Official Title:** A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early-Stage Parkinson's Disease

**Trial ID:** [NCT07174310](https://clinicaltrials.gov/study/NCT07174310)

## Key Facts

- **Phase:** PHASE3
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Hoffmann-La Roche
- **Target Enrollment:** 900 participants
- **Start Date:** 2025-11-24
- **Completion Date:** 2029-06-30
- **Conditions:** Parkinson's Disease
- **Interventions:** Prasinezumab, Placebo
- **Intervention Types:** DRUG

## Summary For Families

The goal is to see if prasinezumab can slow early Parkinson's by reducing toxic alpha-synuclein clumps that are thought to drive nerve cell damage and disease progression. Prasinezumab is an intravenous monoclonal antibody that binds aggregated alpha-synuclein to promote its clearance and limit its spread, it is given on top of a single Parkinson's medication and is intended as a potential disease-modifying treatment rather than a symptomatic replacement for levodopa. The trial is enrolling people 50 to 85 years old with idiopathic PD at Hoehn and Yahr stage 1 or 2 who are on stable monotherapy with no motor complications, with standard weight and contraception requirements and exclusions for other neurologic disease, pregnancy, or uncontrolled hypertension.

## Eligibility

- **Minimum age:** 50 Years
- **Maximum age:** 85 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Body weight within 40-110 kilograms (kg) (88-242 pounds \[lbs\]) and a body mass index within the range 18-34 kg/m2
* Diagnosis of idiopathic PD based on Movement Disorder Society (MDS) criteria
* Has received monotherapy treatment
* An MDS-UPDRS Part IV score of 0 at screening and prior to randomization
* Hoehn and Yahr (H\&Y) Stage 1 or 2 off medication at screening and prior to randomization
* Agreement to adhere to the contraception requirements

Exclusion Criteria:

* Pregnant or breastfeeding, or intention of becoming pregnant during the study or within the time frame in which contraception is required
* Medical history indicating a parkinsonian syndrome other than idiopathic PD
* Diagnosis of a significant neurologic disease other than PD
* Chronic uncontrolled hypertension
```

## Locations (142)

- University of Alabama at Birmingham, Birmingham, Alabama, United States _(33.5207, -86.8025)_
- Barrow Neurological Institute, Phoenix, Arizona, United States _(33.4484, -112.0740)_
- Neurology Center of North Orange County, Fullerton, California, United States _(33.8703, -117.9253)_
- Keck School of Medicine of USC, Los Angeles, California, United States _(34.0522, -118.2437)_
- Parkinson?s Research Centers of America ? Palo Alto, Palo Alto, California, United States _(37.4419, -122.1430)_
- Profound Research LLC at The Neurology Center of Southern California, Pasadena, California, United States _(34.1478, -118.1445)_
- UCSF Weill Institute for Neurosciences, San Francisco, California, United States _(37.7749, -122.4194)_
- Rocky Mountain Movement Disorders, Englewood, Colorado, United States _(39.6478, -104.9878)_
- Institute for Neurodegenerative Disorders, New Haven, Connecticut, United States _(41.3081, -72.9282)_
- Georgetown University, Washington D.C., District of Columbia, United States _(38.8951, -77.0364)_
- JEM Research LLC, Atlantis, Florida, United States _(26.5909, -80.1009)_
- Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida, United States _(26.3587, -80.0831)_
- K2 - Villages, Lady Lake, Florida, United States _(28.9175, -81.9229)_
- K2 Medical Research-Maitland, Maitland, Florida, United States _(28.6278, -81.3631)_
- Charter Research - Winter Park/Orlando, Orlando, Florida, United States _(28.5383, -81.3792)_
- Hawaii Pacific Neuroscience, Honolulu, Hawaii, United States _(21.3069, -157.8583)_
- Northwestern University Feinberg School Of Medicine, Chicago, Illinois, United States _(41.8500, -87.6500)_
- University of Kansas Medical Center, Kansas City, Kansas, United States _(39.1142, -94.6275)_
- Massachusetts General Hospital, Boston, Massachusetts, United States _(42.3584, -71.0598)_
- Quest Research Institute, Farmington Hills, Michigan, United States _(42.4853, -83.3772)_
- Washington Uni School of Medicine, St Louis, Missouri, United States _(38.6273, -90.1979)_
- Cleveland Clinic Lou Ruvo, Las Vegas, Nevada, United States _(36.1750, -115.1372)_
- Renown Health, Reno, Nevada, United States _(39.5296, -119.8138)_
- University of New Mexico, Albuquerque, New Mexico, United States _(35.0845, -106.6511)_
- Dent Neurological Institute, Amherst, New York, United States _(42.9784, -78.7998)_
- Parkinson's Research Centers of America - Long Island, Commack, New York, United States _(40.8429, -73.2929)_
- Weill Cornell Medical College, New York, New York, United States _(40.7143, -74.0060)_
- NeuroCare Center, Canton, Ohio, United States _(40.7989, -81.3785)_
- Cleveland Clinic, Cleveland, Ohio, United States _(41.4995, -81.6954)_
- The Movement Disorder Clinic of Oklahoma, Tulsa, Oklahoma, United States _(36.1540, -95.9928)_
- Allegheny General Hospital, Pittsburgh, Pennsylvania, United States _(40.4406, -79.9959)_
- Veracity Neuroscience, Memphis, Tennessee, United States _(35.1495, -90.0490)_
- Texas Neurology PA, Dallas, Texas, United States _(32.7831, -96.8067)_
- Central Texas Neurology Consultants, Round Rock, Texas, United States _(30.5083, -97.6789)_
- University of Virginia Health System, Charlottesville, Virginia, United States _(38.0293, -78.4767)_
- VCU Health North Hospital, Richmond, Virginia, United States _(37.5538, -77.4603)_
- West Virginia University, Morgantown, West Virginia, United States _(39.6295, -79.9559)_
- Southern Neurology, Kogarah, New South Wales, Australia _(-33.9681, 151.1356)_
- Westmead Hospital, Westmead, New South Wales, Australia _(-33.8038, 150.9877)_
- Monash Health, Clayton, Victoria, Australia _(-37.9167, 145.1167)_
- The Alfred Hospital, Prahan, Victoria, Australia
- Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia _(-31.9818, 115.8073)_
- Medizinische Universität Graz, Graz, Austria _(47.0673, 15.4420)_
- Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck, Innsbruck, Austria _(47.2627, 11.3945)_
- Kepler Universitätsklinikum GmbH - Neuromed Campus, Linz, Austria _(48.3064, 14.2861)_
- Medizinische Universität Wien, Vienna, Austria _(48.2085, 16.3721)_
- Klinik Ottakring, Vienna, Austria _(48.2085, 16.3721)_
- L2 Ip Instituto de Pesquisas Clinicas Ltda ME, Brasília, Federal District, Brazil _(-15.7797, -47.9297)_
- Instituto de Neurologia de Curitiba, Curitiba, Paraná, Brazil _(-25.4278, -49.2731)_
- Núcleo de Pesquisa do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil _(-30.0328, -51.2302)_
- Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP*X*, São José do Rio Preto, São Paulo, Brazil _(-20.8197, -49.3794)_
- Centro de Pesquisas Clinicas, São Paulo, São Paulo, Brazil _(-23.5475, -46.6361)_
- Toronto Western Hospital, Toronto, Ontario, Canada _(43.7064, -79.3986)_
- CHUM, Montreal, Quebec, Canada _(45.5088, -73.5878)_
- Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada _(45.5088, -73.5878)_
- Beijing Friendship Hospital Affiliated of Capital University of Medical Science, Beijing, China _(39.9075, 116.3972)_
- Beijing Tian Tan Hospital,Capital Medical University, Beijing, China _(39.9075, 116.3972)_
- Beijing Hospital of Ministry of Health, Beijing, China _(39.9075, 116.3972)_
- The First Hospital of Jilin University, Changchun, China _(43.8800, 125.3228)_
- West China Hospital of Sichuan University, Chengdu, China _(30.6667, 104.0667)_
- The First Affiliated Hospital, Chongqing Medical University, Chongqing, China _(29.5603, 106.5577)_
- Fujian Medical University Union Hospital, Fuzhou, China _(26.0614, 119.3061)_
- The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China _(23.1167, 113.2500)_
- Guangdong Provincial People's Hospital, Guangzhou, China _(23.1167, 113.2500)_
- The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China _(23.1167, 113.2500)_
- The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China _(30.2936, 120.1614)_
- Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China _(30.2936, 120.1614)_
- Nanjing Brain Hospital, Nanjing, China _(32.0617, 118.7778)_
- Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China _(31.2222, 121.4581)_
- Huashan Hospital, Fudan University, Shanghai, China _(31.2222, 121.4581)_
- The Second Affiliated Hospital of Suzhou University, Suzhou, China _(31.3041, 120.5954)_
- Tianjin Medical University General Hospital, Tianjin, China _(39.1422, 117.1767)_
- First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, China _(34.2583, 108.9286)_
- The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China _(34.2044, 117.2839)_
- Aarhus Universitetshospital Skejby, Aarhus N, Denmark _(56.2037, 10.1732)_
- Bispebjerg Hospital;Neurologisk Afdeling, København NV, Denmark _(55.7126, 12.5234)_
- Hospices Civils de Lyon - Hôpital Pierre Wertheimer, Bron, Rhône, France _(45.7386, 4.9130)_
- APHP - Hopital Henri Mondor, Créteil, France _(48.7927, 2.4657)_
- CHU de Montpellier - Hôpital Gui de Chauliac, Montpellier, France _(43.6109, 3.8763)_
- Kliniken Beelitz GmbH, Beelitz, Germany _(52.2381, 12.9714)_
- Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin, Berlin, Germany _(52.5244, 13.4105)_
- Heinrich-Heine Universitätsklinik Düsseldorf, Düsseldorf, Germany _(51.2232, 6.7793)_
- Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie, Erlangen, Germany _(49.5910, 11.0078)_
- Paracelsus Elena Klinik Kassel, Kassel, Germany _(51.3167, 9.5000)_
- Klinikum rechts der Isar der TU München, Munich, Germany _(48.1374, 11.5755)_
- Universitatsklinikum Munster, Münster, Germany _(51.9624, 7.6257)_
- Universitaettsklinikum Tübingen, Tübingen, Germany _(48.5227, 9.0522)_
- Universitätsklinikum Würzburg, Neurologische Klinik und Poliklinik, Würzburg, Germany _(49.7939, 9.9512)_
- Università degli studi della Campania Luigi Vanvitelli, Naples, Campania, Italy _(40.8522, 14.2681)_
- Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona, Salerno, Campania, Italy _(40.6754, 14.7933)_
- Ospedale Bellaria, Bologna, Emilia-Romagna, Italy _(44.4938, 11.3387)_
- IRCCS San Raffaele;Clinical Trial Center, Rome, Lazio, Italy _(41.8919, 12.5113)_
- Irccs A.O.U.San Martino Ist, Genoa, Liguria, Italy _(44.4048, 8.9444)_
- Azienda Ospedaliera Spedali Civili, Brescia, Lombardy, Italy _(45.5356, 10.2147)_
- Centro Parkinson e Parkinsonismi, Milan, Lombardy, Italy _(45.4643, 9.1895)_
- IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy _(45.4643, 9.1895)_
- IRCCS Istituto Neurologico Carlo Besta, Milan, Lombardy, Italy _(45.4643, 9.1895)_
- A.O. Universitaria Pisana, Pisa, Tuscany, Italy _(43.7085, 10.4036)_
- Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico CITY (federal District), Mexico _(19.4285, -99.1277)_
- Hospital General de Mexico, Mexico City, Mexico CITY (federal District), Mexico _(19.4285, -99.1277)_
- Podlaskie Centrum Psychogeriatrii, Bia?ystok, Poland
- NZOZ Vitamed, Bydgoszcz, Poland _(53.1235, 18.0076)_
- Szpital Sw. Wojciecha, Gda?sk, Poland
- NEURO-CARE Sp. z o.o. Sp. Komandytowa, Katowice, Poland _(50.2597, 19.0217)_
- Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K, Krakow, Poland _(50.0614, 19.9366)_
- Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak., Lublin, Poland _(51.2506, 22.5701)_
- Instytut Zdrowia Dr Boczarska-Jedynak Sp. z o.o. Sp. k., Oświęcim, Poland _(50.0344, 19.2104)_
- Nmedis sp. z o.o., Rzeszów, Poland _(50.0413, 21.9990)_
- NeuroProtect, Warsaw, Poland _(52.2298, 21.0118)_
- Mazowiecki Szpital Bródnowski w Warszawie Sp. z o.o., Warsaw, Poland _(52.2298, 21.0118)_
- Hospital de Braga, Braga, Portugal _(41.5514, -8.4231)_
- Hospital da Luz Coimbra, Coimbra, Portugal _(40.2069, -8.4200)_
- Hospital Dr. Nélio Mendonça;Serviço de Neurologia, Funchal, Portugal _(32.6657, -16.9255)_
- Hospital Pedro Hispano, Matosinhos Municipality, Portugal _(41.1821, -8.6891)_
- CNS - Campus Neurológico, Torres Vedras, Portugal _(39.0911, -9.2586)_
- Severance Hospital, Yonsei University Health System, Seoul, South Korea _(37.5660, 126.9784)_
- Asan Medical Center, Seoul, South Korea _(37.5660, 126.9784)_
- Boramae Medical Center, Seoul, South Korea _(37.5660, 126.9784)_
- Seoul National University Hospital, Seoul, South Korea _(37.5660, 126.9784)_
- Hospital General Universitario de Elche, Elche, Alicante, Spain _(38.2622, -0.7011)_
- Hospital General De Catalunya, Sant Cugat del Vallès, Barcelona, Spain _(41.4706, 2.0861)_
- Policlinica Guipuzcoa, Donostia / San Sebastian, Guipuzcoa, Spain _(43.3128, -1.9750)_
- Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain _(40.3458, -3.8249)_
- Hospital Quiron de Madrid, Pozuelo de Alarcón, Madrid, Spain _(40.4329, -3.8134)_
- Hospital Universitari Vall d Hebron, Barcelona, Spain _(41.3888, 2.1590)_
- Hospital Clinic Barcelona, Barcelona, Spain _(41.3888, 2.1590)_
- Hospital Ruber Juan Bravo, Madrid, Spain _(40.4165, -3.7026)_
- Hospital Universitario de La Princesa, Madrid, Spain _(40.4165, -3.7026)_
- Hospital Univ 12 de Octubre, Madrid, Spain _(40.4165, -3.7026)_
- Hospital Regional Universitario de Malaga ? Hospital General, Málaga, Spain _(36.7202, -4.4203)_
- Changhua Christian Hospital, Changhua County, Taiwan
- China Medical University Hospital, North Dist., Taiwan
- National Cheng Kung University Hospital, Tainan, Taiwan _(22.9908, 120.2133)_
- National Taiwan University Hospital, Taipei, Taiwan _(25.0531, 121.5264)_
- Taipei Veterans General Hospital, Taipei, Taiwan _(25.0531, 121.5264)_
- Ninewells Hospital, Dundee- Scotland, Dundee, United Kingdom _(56.4691, -2.9749)_
- Royal Devon and Exeter Hospital (Wonford), Exeter, United Kingdom _(50.7236, -3.5275)_
- Royal London Hospital, London, United Kingdom _(51.5085, -0.1257)_
- Charing Cross Hospital, London, United Kingdom _(51.5085, -0.1257)_
- Campus for Ageing and Vitality, Newcastle, United Kingdom _(54.2180, -5.8898)_
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom _(51.7522, -1.2560)_
- Plymouth Hospitals NHS Trust - Derriford Hospital, Plymouth,Devon, United Kingdom _(50.3715, -4.1430)_

## Central Contacts

- Reference Study ID Number: BN44715 https://forpatients.roche.com/ — (CONTACT) — 888-662-6728 (U.S. and Canada) — global-roche-genentech-trials@gene.com

## Recent Site Changes (last 30 days)

- **ADDED** — University of Alabama at Birmingham, Birmingham, Alabama, United States _(detected 2026-05-07)_
- **ADDED** — Barrow Neurological Institute, Phoenix, Arizona, United States _(detected 2026-05-07)_
- **ADDED** — Georgetown University, Washington D.C., District of Columbia, United States _(detected 2026-05-07)_
- **ADDED** — Northwestern University Feinberg School Of Medicine, Chicago, Illinois, United States _(detected 2026-05-07)_
- **ADDED** — Cleveland Clinic Lou Ruvo, Las Vegas, Nevada, United States _(detected 2026-05-07)_
- **ADDED** — University of New Mexico, Albuquerque, New Mexico, United States _(detected 2026-05-07)_
- **ADDED** — Allegheny General Hospital, Pittsburgh, Pennsylvania, United States _(detected 2026-05-07)_
- **ADDED** — VCU Health North Hospital, Richmond, Virginia, United States _(detected 2026-05-07)_
- **ADDED** — Medizinische Universität Wien, Vienna, Austria _(detected 2026-05-07)_
- **ADDED** — L2 Ip Instituto de Pesquisas Clinicas Ltda ME, Brasília, Federal District, Brazil _(detected 2026-05-07)_
- **ADDED** — Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP*X*, São José do Rio Preto, São Paulo, Brazil _(detected 2026-05-07)_
- **ADDED** — Toronto Western Hospital, Toronto, Ontario, Canada _(detected 2026-05-07)_
- **ADDED** — Beijing Tian Tan Hospital,Capital Medical University, Beijing, China _(detected 2026-05-07)_
- **ADDED** — Beijing Hospital of Ministry of Health, Beijing, China _(detected 2026-05-07)_
- **ADDED** — Guangdong Provincial People's Hospital, Guangzhou, China _(detected 2026-05-07)_
- **ADDED** — The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China _(detected 2026-05-07)_
- **ADDED** — Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China _(detected 2026-05-07)_
- **ADDED** — Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China _(detected 2026-05-07)_
- **ADDED** — Huashan Hospital, Fudan University, Shanghai, China _(detected 2026-05-07)_
- **ADDED** — Tianjin Medical University General Hospital, Tianjin, China _(detected 2026-05-07)_
- **ADDED** — First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, China _(detected 2026-05-07)_
- **ADDED** — The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China _(detected 2026-05-07)_
- **ADDED** — Hospices Civils de Lyon - Hôpital Pierre Wertheimer, Bron, Rhône, France _(detected 2026-05-07)_
- **ADDED** — APHP - Hopital Henri Mondor, Créteil, France _(detected 2026-05-07)_
- **ADDED** — CHU de Montpellier - Hôpital Gui de Chauliac, Montpellier, France _(detected 2026-05-07)_
- **ADDED** — Kliniken Beelitz GmbH, Beelitz, Germany _(detected 2026-05-07)_
- **ADDED** — Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin, Berlin, Germany _(detected 2026-05-07)_
- **ADDED** — Universitatsklinikum Munster, Münster, Germany _(detected 2026-05-07)_
- **ADDED** — Universitaettsklinikum Tübingen, Tübingen, Germany _(detected 2026-05-07)_
- **ADDED** — Universitätsklinikum Würzburg, Neurologische Klinik und Poliklinik, Würzburg, Germany _(detected 2026-05-07)_
- **ADDED** — Ospedale Bellaria, Bologna, Emilia-Romagna, Italy _(detected 2026-05-07)_
- **ADDED** — IRCCS San Raffaele;Clinical Trial Center, Rome, Lazio, Italy _(detected 2026-05-07)_
- **ADDED** — Azienda Ospedaliera Spedali Civili, Brescia, Lombardy, Italy _(detected 2026-05-07)_
- **ADDED** — Centro Parkinson e Parkinsonismi, Milan, Lombardy, Italy _(detected 2026-05-07)_
- **ADDED** — IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy _(detected 2026-05-07)_
- **ADDED** — A.O. Universitaria Pisana, Pisa, Tuscany, Italy _(detected 2026-05-07)_
- **ADDED** — Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico CITY (federal District), Mexico _(detected 2026-05-07)_
- **ADDED** — Boramae Medical Center, Seoul, South Korea _(detected 2026-05-07)_
- **ADDED** — Hospital General Universitario de Elche, Elche, Alicante, Spain _(detected 2026-05-07)_
- **ADDED** — Hospital Regional Universitario de Malaga ? Hospital General, Málaga, Spain _(detected 2026-05-07)_
- **ADDED** — National Cheng Kung University Hospital, Tainan, Taiwan _(detected 2026-05-07)_

---

*Canonical: https://parkinsonspathways.com/trial/NCT07174310*  
*HTML version: https://parkinsonspathways.com/trial/NCT07174310*  
*Source data: https://clinicaltrials.gov/study/NCT07174310*