---
title: Reduce cognitive decline through exercise
nct_id: NCT07324330
phase: NA
status: RECRUITING
sponsor: University Hospital, Bonn
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07324330"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07324330"
last_fetched: "2026-05-10T14:02:03.816Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce cognitive decline through exercise

**Goal (in five words):** Reduce cognitive decline through exercise

**Official Title:** Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity

**Trial ID:** [NCT07324330](https://clinicaltrials.gov/study/NCT07324330)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University Hospital, Bonn
- **Target Enrollment:** 130 participants
- **Start Date:** 2025-12-04
- **Completion Date:** 2028-12-01
- **Conditions:** Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases, Central Nervous System Diseases, Synucleinopathies, Nervous System Diseases, Cerebral Disorder, Brain Diseases, Parkinsonian Disorders
- **Interventions:** Increase of physical activity volume and intensity with the use of a motivational smartphone application
- **Intervention Types:** BEHAVIORAL

## Summary For Families

The goal is to slow early cognitive decline linked to alpha-synuclein disorders by boosting physical activity in people at high risk of Parkinson's, especially those with polysomnography-confirmed idiopathic REM sleep behavior disorder. The approach uses a motivational smartphone app that tracks steps and activity and gives tailored prompts to raise daily volume and intensity of exercise, because more regular, higher-intensity movement can improve brain blood flow and neuroplasticity and may help slow cognitive changes. It is a non-drug, lifestyle intervention, so it does not interact with medications like levodopa. The trial is looking for adults 50 to 80 years old, both iRBD patients and healthy controls, who average under 10,000 steps per day, have basic smartphone skills and German fluency, own a compatible phone, and do not have major cardiovascular disease or significant cognitive or dexterity problems.

## Eligibility

- **Minimum age:** 50 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

iRBD:

* Age: 50-80 years
* Polysomnographically confirmed diagnosis of iRBD
* Maximum of 120 minutes of sports/outdoor activities per day
* Less than an average of 10,000 steps per day during the 4-week eligibility and baseline phase
* Basic smartphone skills
* Sufficient knowledge of German (native language, C1 or C2)
* Ownership of a suitable smartphone (minimum screen size 4.6 inches, Android version 9 or iOS version 15 or newer)
* Consent to be informed of any additional findings

Healthy controls:

* Age: 50-80 years
* Maximum of 120 minutes of sports/outdoor activities per day
* Less than an average of 10,000 steps per day during the 4-week eligibility and baseline phase
* Basic smartphone skills
* Sufficient knowledge of German (native language, C1 or C2)
* Ownership of a suitable smartphone (minimum screen size 4.6 inches, Android version 9 or iOS version 15 or newer)
* Consent to be informed of any additional findings

Exclusion Criteria:

iRBD:

* Relevant cardiovascular diseases
* Problems with dexterity or cognitive impairments that make it difficult to use a smartphone
* Cognitive impairments that limit the ability to make informed decisions and consent to participate in the study
* Ownership of one of the following devices: Huawei P8 Lite, Huawei P9 Lite, Xiaomi Mi 6, Huawei P20 Lite (FitBit is not compatible)

Healthy controls:

* Relevant cardiovascular diseases
* Problems with dexterity or cognitive impairments that make it difficult to use a smartphone
* Cognitive impairments that limit the ability to make informed decisions and consent to participate in the study
* Ownership of one of the following devices: Huawei P8 Lite, Huawei P9 Lite, Xiaomi Mi 6, Huawei P20 Lite (FitBit is not compatible)
* clinically diagnosed iRBD
```

## Locations (1)

- University Hospital of Bonn, Bonn, North Rhine West-Falia, Germany _(50.7344, 7.0955)_
  - Michael B Sommerauer, Dr. — (CONTACT) — +49 0228 287 - 19436 — Michael.Sommerauer@ukbonn.de

## Central Contacts

- Martin M Rodemann — (CONTACT) — +49 0228 287 - 19436 — Martin.Rodemann@ukbonn.de
- Emily L Fitzgibbon, M.Sc. — (CONTACT) — Emily.Fitzgibbon@ukbonn.de

---

*Canonical: https://parkinsonspathways.com/trial/NCT07324330*  
*HTML version: https://parkinsonspathways.com/trial/NCT07324330*  
*Source data: https://clinicaltrials.gov/study/NCT07324330*