---
title: Personalize brain stimulation to symptoms
nct_id: NCT07336199
status: RECRUITING
sponsor: Ludwig-Maximilians - University of Munich
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07336199"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07336199"
last_fetched: "2026-05-10T14:06:02.516Z"
source: "Parkinson's Pathways (curated)"
---
# Personalize brain stimulation to symptoms

**Goal (in five words):** Personalize brain stimulation to symptoms

**Official Title:** Pairing Subjective Patient Rating and Local Field Potentials for DBS Programming

**Trial ID:** [NCT07336199](https://clinicaltrials.gov/study/NCT07336199)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Ludwig-Maximilians - University of Munich
- **Target Enrollment:** 25 participants
- **Start Date:** 2024-12-02
- **Completion Date:** 2026-07-01
- **Conditions:** Parkinson's Disease (PD)
- **Interventions:** No intervention (observational study)
- **Intervention Types:** OTHER

## Summary For Families

The team aims to make deep brain stimulation programming more precise by matching patients' brief symptom and side effect ratings with the brain's electrical signals, so clinicians can pick settings that better control Parkinson's signs. They will record local field potentials, the small electrical rhythms from the subthalamic nucleus captured by sensing-enabled implanted pulse generators, while participants report how they feel, then look for signal patterns that correspond to better or worse symptom control; nothing new is implanted or given, it is observational. About 25 people aged 35 to 80 with clinician-confirmed idiopathic Parkinson's who already have bilateral STN-DBS with a device that can record signals, who can consent and communicate reliably, and who do not have dementia or severe medical or psychiatric conditions are eligible.

## Eligibility

- **Minimum age:** 35 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

Age between 35 and 80 years

Clinically confirmed idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria

Status post bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS)

Implanted DBS system suitable for electrophysiological recordings (prospective cohort: sensing-enabled IPG)

Ability to understand study procedures and communicate reliably with the investigator

Written informed consent provided

Exclusion Criteria:

Any condition impairing the ability to provide informed consent or comply with study procedures

Presence of exclusion criteria for Parkinson's disease according to MDS criteria

Manifest dementia according to ICD-10 criteria

Severe neurological, psychiatric, or medical conditions interfering with study participation or assessments
```

## Locations (1)

- LMU University Hospital, München, Germany _(51.6070, 13.3124)_
  - PD Dr. med. Thomas Köglsperger, MHBA — (CONTACT) — 089440046433 — thomas.koeglsperger@med.uni-muenchen.de

## Central Contacts

- Thomas Köglsperger, PD Dr. med., MHBA — (CONTACT) — +4989440073901 — thomas.koeglsperger@med.uni-muenchen.de

---

*Canonical: https://parkinsonspathways.com/trial/NCT07336199*  
*HTML version: https://parkinsonspathways.com/trial/NCT07336199*  
*Source data: https://clinicaltrials.gov/study/NCT07336199*