---
title: Improve walking using resistance training
nct_id: NCT07378813
phase: NA
status: RECRUITING
sponsor: University of Miami
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07378813"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07378813"
last_fetched: "2026-05-10T14:06:51.216Z"
source: "Parkinson's Pathways (curated)"
---
# Improve walking using resistance training

**Goal (in five words):** Improve walking using resistance training

**Official Title:** Comparison of Changes in Neuromuscular and Functional Performance Due to Resistance Training With Low-Load or High-Load in Persons With Parkinson's Disease.

**Trial ID:** [NCT07378813](https://clinicaltrials.gov/study/NCT07378813)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University of Miami
- **Target Enrollment:** 60 participants
- **Start Date:** 2026-01-30
- **Completion Date:** 2027-05-30
- **Conditions:** Activity, Motor
- **Interventions:** Low-Load Resistance Training, High-Load Resistance Training
- **Intervention Types:** BEHAVIORAL

## Summary For Families

The goal is to find whether low-load or high-load resistance training better improves muscle strength, power, and everyday mobility in people with early to mid-stage Parkinson's. Participants will follow supervised weight programs using either lighter weights with higher reps to build muscle endurance and motor control, or heavier weights with lower reps to build strength and power, with the idea that stronger leg and core muscles can improve gait, balance, and transfers. The program is done alongside usual medical care, so it does not replace medications like levodopa and may help medications work better by improving overall movement and functional reserve. They plan to enroll 60 people aged 50 to 85 with Parkinson's at Hoehn and Yahr stages 1 to 3 who can walk 50 meters unassisted and have a MoCA above 18, excluding those with uncontrolled cardiovascular or neuromuscular disease, systemic inflammatory or autoimmune conditions, or unresolved limb injuries that prevent weight training.

## Eligibility

- **Minimum age:** 50 Years
- **Maximum age:** 85 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Parkinson's Disease Hoehn \& Yahr Stages 1-3
* Able to walk 50m unassisted
* Able to understand and communicate in English
* A Montreal Cognitive Assessment (MoCA) score above 18

Exclusion Criteria:

* Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
* Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
* Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
```

## Locations (1)

- Laboratory of Neruomuscular Research and Active Aging, Coral Gables, Florida, United States _(25.7215, -80.2684)_
  - Ethan Elway, MS — (CONTACT) — 305-284-4173 — exe453@miami.edu
  - Joseph F. Signorile, PhD — (CONTACT) — 3052843105 — JSIGNORILE@MIAMI.EDU
  - Joseph F. Signorile, PhD — (PRINCIPAL_INVESTIGATOR)

## Central Contacts

- Ethan J Elway, MS — (CONTACT) — 3052844173 — exe453@miami.edu
- Joseph F. Signorile, PhD — (CONTACT) — 3052843105 — jsignorile@miami.edu

---

*Canonical: https://parkinsonspathways.com/trial/NCT07378813*  
*HTML version: https://parkinsonspathways.com/trial/NCT07378813*  
*Source data: https://clinicaltrials.gov/study/NCT07378813*