---
title: Detect Parkinson and track severity
nct_id: NCT07392411
status: RECRUITING
sponsor: Beijing Tiantan Hospital
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07392411"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07392411"
last_fetched: "2026-05-10T14:04:23.917Z"
source: "Parkinson's Pathways (curated)"
---
# Detect Parkinson and track severity

**Goal (in five words):** Detect Parkinson and track severity

**Official Title:** Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers

**Trial ID:** [NCT07392411](https://clinicaltrials.gov/study/NCT07392411)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** Beijing Tiantan Hospital
- **Target Enrollment:** 720 participants
- **Start Date:** 2023-07-25
- **Completion Date:** 2026-12-31
- **Conditions:** Parkinson's Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy, Healthy Control
- **Interventions:** video recording
- **Intervention Types:** OTHER

## Summary For Families

Researchers are using AI to detect and quantify subtle changes in facial expression and speech that could become digital biomarkers to help detect Parkinson's disease, distinguish Parkinson-plus conditions like PSP and MSA, and track disease severity over time. They record short videos and audio of your face and voice, then use algorithms to measure things like reduced facial expressivity, slowed or softer speech, altered pitch and timing, and other motor-related voice signals, all noninvasively and without changing your medications. The study is looking for adults 18 to 75 with diagnosed PD, PSP, or MSA, plus healthy controls who can consent and tolerate recording; people with significant cognitive impairment (MMSE ≤ 24), major brain injury or surgery, severe dyskinesia that prevents reliable recording, and other listed exclusions are not eligible.

## Eligibility

- **Minimum age:** 15 Years
- **Maximum age:** 75 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

1. Inclusion Criteria for Parkinson's Disease (PD) Group: (1) Diagnostic Criteria: Meet the diagnostic criteria for Parkinson's disease established by the Movement Disorder Society (MDS) in 2015. (2) Age Range: 18-75 years old. (3) Disease Severity: Early-stage PD: Hoehn-Yahr score ≤ 2.5 points. Mid-to-late-stage PD: Hoehn-Yahr score 2.5-5 points. (4) Consent for Data Collection: Willing to undergo facial expression video and speech audio recording. (5) Informed Consent: Signed informed consent form.
2. Inclusion Criteria for Parkinson's Plus Syndromes (MSA-P, PSP) Group: (1) Age Range: 18-75 years old. (2) Diagnostic Criteria: MSA patients must meet the diagnostic criteria established by the \[Chinese Expert Consensus on the Diagnosis of Multiple System Atrophy, 2017\]. PSP patients must meet the diagnostic criteria established by the \[Chinese Clinical Diagnostic Criteria for Progressive Supranuclear Palsy, 2016 Edition\]. (3) Consent for Data Collection: Willing to undergo facial expression video and speech audio recording. (4) Informed Consent: Signed informed consent form.

Exclusion Criteria:

1. History of cerebrovascular disease, head trauma, hydrocephalus, brain tumors, or intracranial surgery.
2. Presence of metal implants, cardiac pacemakers, or other metallic foreign bodies (applies to PD patients).
3. Severe dyskinesia in PD patients that would compromise cooperation with video/audio recording.
4. Mini-Mental State Examination (MMSE) score ≤ 24 points.
```

## Locations (1)

- 首都医科大学附属北京天坛医院, Beijing, Beijing Municipality, China _(39.9075, 116.3972)_
  - Lingyan ma Jennifer, M.D. — (CONTACT) — 01059976611 — Jennifer_MLY@163.com

## Central Contacts

- Lingyan Ma, M.D. — (CONTACT) — +8613520873987 — Jennifer_MLY@163.com

---

*Canonical: https://parkinsonspathways.com/trial/NCT07392411*  
*HTML version: https://parkinsonspathways.com/trial/NCT07392411*  
*Source data: https://clinicaltrials.gov/study/NCT07392411*