---
title: Reduce motor and neuropsychiatric fluctuations
nct_id: NCT07404241
status: RECRUITING
sponsor: University Hospital, Geneva
study_type: OBSERVATIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07404241"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07404241"
last_fetched: "2026-05-10T14:04:59.545Z"
source: "Parkinson's Pathways (curated)"
---
# Reduce motor and neuropsychiatric fluctuations

**Goal (in five words):** Reduce motor and neuropsychiatric fluctuations

**Official Title:** Subthalamic and Cortical Electrophysiological Correlates of Motor and Neuropsychiatric Fluctuations in Parkinson's Disease

**Trial ID:** [NCT07404241](https://clinicaltrials.gov/study/NCT07404241)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Sponsor:** University Hospital, Geneva
- **Target Enrollment:** 30 participants
- **Start Date:** 2025-06-01
- **Completion Date:** 2027-12-31
- **Conditions:** PARKINSON DISEASE (Disorder)

## Summary For Families

The goal is to identify specific electrical brain signals in the subthalamic nucleus and cortex that line up with the motor and neuropsychiatric ups and downs people with Parkinson's often experience. To do that, researchers will record electrophysiological activity from the STN and cortical areas around the time of deep brain stimulation surgery using the implanted electrodes while participants are on dopaminergic medication, since levodopa changes brain rhythms and symptoms; STN-DBS normally treats motor fluctuations by delivering electrical pulses to the subthalamic nucleus to modulate abnormal circuits, and these recordings may show which signals drive motor or mood swings. Adults 18 to 80 with Parkinson's in the fluctuation stage who are candidates for STN-DBS or had STN-DBS implanted 4 to 8 weeks earlier, who are on dopaminergic therapy and do not have dementia, active psychosis, or other major unstable illnesses, can be enrolled.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 80 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Diagnosis of Parkinson's disease (PD) based on United Kingdom Parkinson's Disease Society Brain Bank Criteria.
* Patients candidate for STN-DBS in the PD phase called fluctuations stage.
* Presence of fluctuations (motor and/or non-motor) are based on the pre-surgical DBS assessment:
* To be on dopaminergic therapy.
* Patients who have undergone STN-DBS implantation within 4 to 8 weeks before electrophysiological acquisition.

Exclusion Criteria:

* Patients with an age greater than 80 years,
* Dementia (defined by a MOCA score ≤24),
* Active psychosis or depression with suicidal ideation,
* Any clinically meaningful non-stable physical diseases,
* Patients with OFF-drug state so severe that it prevents study tests from being carried out (e.g acute painful dystonia, intolerable non-motor symptoms such as pain, anxiety),
* Participating in a pharmacological study,
* Inability to provide informed consent (legal guardianship).
```

## Locations (1)

- Geneva University Hospital, Geneva, Switzerland _(46.2022, 6.1457)_
  - Damien Benis, PhD — (CONTACT) — +41223722311 — damien.benis@hug.ch
  - Vanessa Fleury, MD, PD — (PRINCIPAL_INVESTIGATOR)

## Central Contacts

- Damien BENIS, PhD — (CONTACT) — +41223722311 — damien.benis@hug.ch

---

*Canonical: https://parkinsonspathways.com/trial/NCT07404241*  
*HTML version: https://parkinsonspathways.com/trial/NCT07404241*  
*Source data: https://clinicaltrials.gov/study/NCT07404241*