---
title: Improve gait with C Mill
nct_id: NCT07434089
phase: NA
status: RECRUITING
sponsor: IRCCS Centro Neurolesi Bonino Pulejo
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07434089"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07434089"
last_fetched: "2026-05-10T14:03:29.116Z"
source: "Parkinson's Pathways (curated)"
---
# Improve gait with C Mill

**Goal (in five words):** Improve gait with C Mill

**Official Title:** Gut-Brain Axis and Rehabilitation: Study on the Effects of C-Mill Technology on the Intestinal Microbiota of Parkinson's Disease Patients

**Trial ID:** [NCT07434089](https://clinicaltrials.gov/study/NCT07434089)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** IRCCS Centro Neurolesi Bonino Pulejo
- **Target Enrollment:** 60 participants
- **Start Date:** 2025-10-20
- **Completion Date:** 2027-10-20
- **Conditions:** Parkinson Disease
- **Interventions:** C-Mill technology treadmill equipped with semi-immersive VR, C-Mill treatment without semi-immersive virtual reality (VR), Conventional physiotherapy training
- **Intervention Types:** DEVICE, OTHER

## Summary For Families

Researchers are testing whether targeted gait rehabilitation using the C-Mill can shift the intestinal microbiota via the gut-brain axis, which might relate to motor and non-motor Parkinson's symptoms. The C-Mill is an instrumented treadmill that delivers precise walking tasks, real-time feedback and semi-immersive virtual reality scenes to challenge and retrain gait and balance, the trial compares C-Mill with VR, C-Mill without VR, and conventional physiotherapy to see if that sensorimotor stimulation changes gut signals and bacterial communities. The study is enrolling about 60 people aged 40 to 70 with moderate to advanced PD, Hoehn and Yahr stages 2 to 4, who can walk independently. People with major gastrointestinal disease, recent antibiotics/probiotics or drugs that affect GI motility, recent GI surgery, or extreme height/weight are excluded.

## Eligibility

- **Minimum age:** 40 Years
- **Maximum age:** 70 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Diagnosis of PD according to the Movement Disorder Society Clinical
* Diagnostic Criteria for Parkinson's Disease
* Age comprised between 40 to 70 years
* Patients with moderate to advanced disease (2 ≤ Hoehn and Yahr classification grade ≤ 4)
* Individuals able to walk independently (FAC \> 2)

Exclusion Criteria:

* PD patients with (1) weight \> 135 kg and Height \> 200 cm
* Open lesions or bandages whether in contact with the harness of C-Mill strumentation
* chronic gastro-intestinal (GI) disease including malabsorption;
* clinical history of gastric lesions, gastro-resection or major intestinal surgery;
* systemic and/or neurologic infectious, inflammatory, or autoimmune diseases of gastro-intestinal (GI) eg. Chron disease;
* Acute GI phlogosis or GI disease in the last 4 weeks before recruitment;
* Use of domperidone, or any drug potentially affecting gastrointestinal motility and integrity;
* Use, in the last 4 weeks preceding the recruitment and until t2, of pre-probiotics or therapy based upon steroids, nonsteroidal anti-inflammatory drugs, antibiotics or antifungals;
* anamnesis suggestive of GI cancer pathology.
```

## Locations (1)

- Irccs Centro Neurolesi Bonino Pulejo, Messina, Messina, Italy _(38.1939, 15.5526)_
  - Maria Lui — (CONTACT) — (+39) 09060128163 — maria.lui@irccsme.it

---

*Canonical: https://parkinsonspathways.com/trial/NCT07434089*  
*HTML version: https://parkinsonspathways.com/trial/NCT07434089*  
*Source data: https://clinicaltrials.gov/study/NCT07434089*