---
title: Slow Parkinson progression through lifestyle
nct_id: NCT07443293
phase: PHASE2
status: RECRUITING
sponsor: University of British Columbia
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07443293"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07443293"
last_fetched: "2026-05-10T14:04:17.645Z"
source: "Parkinson's Pathways (curated)"
---
# Slow Parkinson progression through lifestyle

**Goal (in five words):** Slow Parkinson progression through lifestyle

**Official Title:** IMPACT 360 Study for Parkinson's Disease

**Trial ID:** [NCT07443293](https://clinicaltrials.gov/study/NCT07443293)

## Key Facts

- **Phase:** PHASE2
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** University of British Columbia
- **Target Enrollment:** 60 participants
- **Start Date:** 2024-10-28
- **Completion Date:** 2027-05-31
- **Conditions:** Parkinson's Disease (PD), REM Sleep Behavior Disorder
- **Interventions:** Exercise, Meditation, Diet
- **Intervention Types:** BEHAVIORAL

## Summary For Families

IMPACT 360 is testing whether a coordinated program of exercise, meditation, and a brain-healthy diet can improve motor symptoms, reduce REM sleep behavior disorder events, and support thinking and overall quality of life in people with early Parkinson's or isolated RBD. The program pairs guided physical training to build strength, balance, and endurance, mindfulness meditation to lower stress and improve sleep and attention, and a MIND-style diet to reduce inflammation and support brain cells; these lifestyle changes are meant to complement, not replace, medications like levodopa. The study is enrolling adults 40 to 85 with early-stage Parkinson's (Hoehn and Yahr 1-2) or polysomnography-confirmed RBD who can follow instructions and use a smartphone and a computer for remote sessions. People with significant cognitive impairment (MoCA <21), medical or cardiac contraindications to exercise, current heavy exercisers or those who already completed an MBSR course or score high on the MIND diet, or anyone with MRI contraindications are excluded.

## Eligibility

- **Minimum age:** 40 Years
- **Maximum age:** 85 Years
- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

* Age 40-85 years
* A diagnosis of either PD, based on the Movement Disorder Society (MDS) criteria, OR, RBD, through a polysomnography
* Hoehn \& Yahr score of 1 to 2
* Able to fill out questionnaires
* Able to follow instructions and directions as required by the intervention.
* Have access to the necessary technologies (i.e., a working smartphone for Fitbit, a laptop or tablet for Zoom) as required by the intervention.

Exclusion Criteria:

* Any chronic medical condition which would affect ability to participate in exercise
* Any contraindication for exercise based on the Physical Activity Readiness for Everyone Questionnaire (PAR-Q+) and medical clearance form
* Significant cognitive impairment, depression, or eating disorder
* Score \<21/30 on the Montreal Cognitive Assessment (MoCA)
* Any contraindication to MRI scanning; such as implanted metal clips or wires (see list below)
* Participants who were told by a medical doctor that they need to be medically supervised for exercise
* Participants currently doing 180 minutes or more of moderate-vigorous intensity exercise per week AND either of the following:

Completion of a Mindfulness-Based Stress Reduction course OR; Score \>8/15 in the MIND Diet Questionnaire

* Significant or unstable cardiovascular or respiratory disease
* Severe/multiple head trauma(s)
* Subjects who are pregnant or breastfeeding
* Subjects with a history or major episodes of drug or alcohol abuse
* Chronic/acute bacterial/viral infection
* GI cancer
* Inflammatory bowel disease

Exclusion for MRI scanning:

* Individuals weighing \> 400 lbs (limit of MRI machine)
* Artificial heart valve
* Brain aneurysm clip
* Electrical stimulator for nerves or bones
* Ear or eye implant
* Implanted drug infusion pump
* Coil, catheter, or filter in any blood vessel
* Orthopedic hardware (artificial joint, plate, screws)
* Other metallic prostheses
* Shrapnel, bullets, or other metal fragments
* Surgery or tattoos (including tattooed eyeliner) in the last six weeks
* Brain surgery
* Have a cardiac pacemaker, wires or defibrillator
* Have had an injury where a piece of metal lodged in the eye or orbit
* Have a ferromagnetic aneurysm clip
```

## Locations (1)

- University of British Colombia, Vancouver, British Columbia, Canada _(49.2497, -123.1193)_
  - Jeffrey Kelly — (CONTACT) — 604-827-4230 — jeff.kelly@ubc.ca
  - Annie Kuan — (CONTACT) — 604-827-0576 — annie.kuan@ubc.ca
  - Silke Appel-Cresswell — (PRINCIPAL_INVESTIGATOR)

## Central Contacts

- Jeffrey Kelly — (CONTACT) — 604-827-4230 — jeff.kelly@ubc.ca
- Annie Kuan — (CONTACT) — 604-827-0576 — annie.kuan@ubc.ca

---

*Canonical: https://parkinsonspathways.com/trial/NCT07443293*  
*HTML version: https://parkinsonspathways.com/trial/NCT07443293*  
*Source data: https://clinicaltrials.gov/study/NCT07443293*