---
title: Improve movement with brain stimulation
nct_id: NCT07524400
phase: NA
status: RECRUITING
sponsor: Universidad Rey Juan Carlos
study_type: INTERVENTIONAL
canonical_url: "https://parkinsonspathways.com/trial/NCT07524400"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT07524400"
last_fetched: "2026-05-10T14:05:35.216Z"
source: "Parkinson's Pathways (curated)"
---
# Improve movement with brain stimulation

**Goal (in five words):** Improve movement with brain stimulation

**Official Title:** Effects of the Combination of Physical Exercise and Transcranial Direct Current Stimulation on Motor Function and Underlying Neurophysiological Mechanisms in Parkinson's Disease

**Trial ID:** [NCT07524400](https://clinicaltrials.gov/study/NCT07524400)

## Key Facts

- **Phase:** NA
- **Status:** RECRUITING
- **Study Type:** INTERVENTIONAL
- **Sponsor:** Universidad Rey Juan Carlos
- **Target Enrollment:** 100 participants
- **Start Date:** 2026-05-10
- **Completion Date:** 2026-08-01
- **Conditions:** Parkinson' Disease
- **Interventions:** real tDCS and exercise, Sham tDCS and exercise, Exercise
- **Intervention Types:** OTHER

## Summary For Families

The trial asks whether pairing exercise with noninvasive brain stimulation can improve motor function and the underlying brain activity that supports movement in Parkinson's. Participants do supervised exercise while receiving either real transcranial direct current stimulation, sham stimulation, or exercise alone; tDCS delivers a low electrical current across the scalp to boost cortical excitability and plasticity, which may enhance motor learning and rehabilitation, and it is given alongside stable antiparkinsonian medications rather than replacing levodopa. About 100 adults with idiopathic Parkinson's diagnosed by UK Brain Bank criteria and on stable meds are sought, while people with significant cognitive impairment, major depression, seizure history, deep brain stimulators or other implanted electronic devices, severe heart disease, recent stroke or major orthopedic problems are excluded.

## Eligibility

- **Sex:** ALL

### Full Criteria

```
Inclusion Criteria:

Clinical diagnosis of idiopathic Parkinson's disease, established according to the UK Parkinson's Disease Society Brain Bank Criteria.

Ability to understand and comply with study procedures.

Stable antiparkinsonian medication regimen prior to study participation.

Exclusion Criteria:

Significant cognitive impairment, defined as a score \< 23 on the Mini-Mental State Examination (MMSE).

Below-average premorbid intelligence, defined as a score \< 40 on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Third Edition (WAIS-III).

Clinically significant depression, defined as a score \> 10 on the Geriatric Depression Scale (GDS-15).

Current treatment with cholinesterase inhibitors.

Presence of severe cardiovascular disease, including but not limited to:

Congestive heart failure

Ischemic heart disease

Cardiac pacemaker

Orthostatic hypotension

Uncontrolled diabetes mellitus.

History of stroke or traumatic brain injury.

History of seizure disorder or epilepsy.

Presence or prior implantation of a deep brain stimulation (DBS) device.

History of major orthopedic surgery that could interfere with motor performance or gait.

Presence of implanted electronic devices, including cardiac pacemakers, incompatible with study procedures.
```

## Locations (1)

- Center of Sport Research, Fuenlabrada, Madrid, Spain _(40.2842, -3.7942)_
  - Miguel Angel Fernández del Olmo, PhD — (CONTACT) — 600077866 — miguel.delolmo@urjc.es

## Central Contacts

- Eduardo Villamil Cabell, PhD — (CONTACT) — +34 666 66 81 05 — eduardo.villamil@urjc.es

---

*Canonical: https://parkinsonspathways.com/trial/NCT07524400*  
*HTML version: https://parkinsonspathways.com/trial/NCT07524400*  
*Source data: https://clinicaltrials.gov/study/NCT07524400*