---
title: "Deep Brain Stimulation Parkinson's Clinical Trials | Parkinson's Pathways"
description: "Recruiting clinical trials studying Deep Brain Stimulation for Parkinson's disease. See which studies are enrolling and get an email when a new Deep Brain Stimulation trial opens."
canonical_url: "https://parkinsonspathways.com/trials/drug/deep-brain-stimulation"
topic_type: drug
source: "Parkinson's Pathways"
---
# Deep Brain Stimulation Clinical Trials for Parkinson's

Deep Brain Stimulation is being studied in recruiting Parkinson's disease clinical trials. This page lists the recruiting trials we currently track that involve Deep Brain Stimulation, sourced daily from ClinicalTrials.gov and translated into plain language for families.

Below are the recruiting trials that name Deep Brain Stimulation. Sign up to be emailed the moment a new Deep Brain Stimulation trial opens.

## 136 recruiting trials

- [Directional Deep Brain Stimulation of the Posterior Subthalamic Area (PSA) Versus Subthalamic Nucleus (STN) for Tremor-dominant Parkinson's Disease: a Prospective, Randomized, Double-blinded, Cross-over Trial](https://parkinsonspathways.com/trial/NCT07700862), Reduce tremor using brain stimulation
- [Investigating the Effects of Tele-Rehabilitation-Based Dual-Task Upper Extremity Training in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07641556), Improve arm and hand dexterity
- [Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06857851), Improve eye alignment and refocusing
- [Automated Daytime Adaptive Deep Brain Stimulation Parameter Optimization in Patients Implanted With Percept Neurostimulator](https://parkinsonspathways.com/trial/NCT07682311), Reduce under and over stimulation
- [A Pilot Study of Acute Intermittent Hypercapnia-Based Interventions on Upper Airway and Axial Motor Function in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07674264), Improve speech cough and breathing
- [Effects of Tai Chi Therapy Versus Qi-Gong on Postural Control, Functional Balance , and Motor Function in Stage-I Parkinson's Patients.](https://parkinsonspathways.com/trial/NCT07662837), Comparing Tai Chi Qigong balance
- [Comparison of Motor-Motor and Cognitive-Motor Dual-Task Training in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07641569), Reduce walking problems when multitasking
- [Clinical Effects of Accelerated rTMS Targeting Motor Cortex on Motor and Cognitive Function in Parkinson's Disease: A Prospective Pilot Study](https://parkinsonspathways.com/trial/NCT07554833), Improve movement and thinking together
- [Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation](https://parkinsonspathways.com/trial/NCT07642908), Link brain chemicals to walking
- [Sensing in Sleep and Deep Brain Stimulation](https://parkinsonspathways.com/trial/NCT07636720), Does stimulation change sleep quality
- [Adaptive vs Conventional Deep Brain Stimulation for Parkinson's Disease: A Multi-center Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07635823), Increase time without involuntary movements
- [Study on the Efficacy and Safety of Subthalamic Nucleus (STN)-Targeted Transcranial Temporal Interference Stimulation (tTIS) for Motor and Non-Motor Symptoms in Parkinson's Disease (PD): A Randomized, Double-Blind, Controlled Exploratory Trial](https://parkinsonspathways.com/trial/NCT07625540), Reduce movement and nonmotor symptoms
- [Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07207122), Reduce tremor using sound waves
- [The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease: A Three-arm, Randomized, Double-blind, Parallel-controlled Study](https://parkinsonspathways.com/trial/NCT07572903), Reduce tremor and movement stiffness
- [Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.](https://parkinsonspathways.com/trial/NCT07398157), Personalize brain stimulation for movement
- [A Single-Center, Double-Blind Randomized Controlled Trial of Accelerated Temporal Interference Stimulation Applied to Bilateral Subthalamic Nucleus for Improving Motor and Vocal Functions in Patients With Parkinson's Disease Or Secondary Parkinson's Syndrome](https://parkinsonspathways.com/trial/NCT07568067), Improve speech with brain stimulation
- [The Effect of MRI-Guided Transcranial Direct Current Stimulation on Cognitive and Affective Symptoms in Persons With Parkinson's Disease and Controls](https://parkinsonspathways.com/trial/NCT06467695), Studying guided stimulation for depression
- [Stimulating the Vagus Nerve to Improve Gait in Veterans With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06562569), Testing neck stimulation for freezing
- [The Effects of Exercise Management in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07302386), Studying self scheduled exercise adherence
- [A Natural History Study of Treated Parkinson's Disease Patients Experiencing Motor Complications](https://parkinsonspathways.com/trial/NCT07330258), Document motor complications despite medication
- [Assessing the Relation Between Subcortical LFPs and DBS Parameter Selection in Parkinson's Disease - a Prospective Study](https://parkinsonspathways.com/trial/NCT07485621), Guide brain stimulation contact selection
- [Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06416345), Wearable cues reduce daily freezing
- [Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients](https://parkinsonspathways.com/trial/NCT07455760), Improve speech sequencing with stimulation
- [Basal Ganglia Contributions to Transitions in Freezing of Gait and Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06848205), Reduce freezing episodes while walking
- [A Prospective Observational Study for the Predictors of Clinical Outcomes of Deep Brain Stimulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07376278), Predict benefit from brain stimulation
- [A Randomized, Placebo-Controlled, Single Ascending Dose (SAD) Study to Assess the Safety, Tolerability, and Pharmacokinetics of SER-252 in Patients With Parkinson's Disease and Motor Fluctuations](https://parkinsonspathways.com/trial/NCT07422675), Reduce early morning movement limitations
- [Somato-cognitive Action Network Targeted Epidural Modulation for Parkinson's Disease (STEM-PD): a Prospective Open-label Clinical Trial](https://parkinsonspathways.com/trial/NCT06919822), Stabilize movement reduce off periods
- [Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders](https://parkinsonspathways.com/trial/NCT07417280), Reduce tremor with focused ultrasound
- [Evaluation of the Safety of Electrical Spinal Cord Stimulation in Parkinson's Patients Presenting With Painful Camptocormia](https://parkinsonspathways.com/trial/NCT06291051), Reduce camptocormia pain with stimulation
- [Investigation of the Effect of the Mediterranean Diet on Nutritional Status in Parkinson's Patients Undergoing Bilateral Subthalamic Nucleus Deep Brain Stimulation](https://parkinsonspathways.com/trial/NCT07187739), Reduce after surgery weight gain
- [Neural Mechanisms and Clinical Applications of Deep Brain Stimulation for Modulating Sleep Dysregulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06914466), Improve sleep with brain stimulation
- [Deep Brain Stimulation Surgery for Movement Disorders](https://parkinsonspathways.com/trial/NCT01581580), Reduce tremor using Medtronic Activa
- [Evaluating the Effect of Mirtazapine on Anxiety in Parkinson's Disease Patients; a Randomized Double-blinded Placebo-controlled Clinical Trial](https://parkinsonspathways.com/trial/NCT06530290), Reduce anxiety symptoms with mirtazapine
- [Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2](https://parkinsonspathways.com/trial/NCT05557864), Map stimulation spots improving movement
- [High Intensity Endurance Exercise as a Primer to Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in Parkinson's Disease (PD)](https://parkinsonspathways.com/trial/NCT06133283), Improve balance using exercise priming
- [Revision of Deep Brain Stimulator in Patients With Parkinson's Disease: A Comparison of Perioperative Characteristics of Regional and General Anesthesia](https://parkinsonspathways.com/trial/NCT07176494), Numbing surgical area speeds recovery
- [Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment](https://parkinsonspathways.com/trial/NCT04715984), Improve cognition through caudate stimulation
- [Study on Preliminary Safety and Efficacy of the ARC-IM Therapy to Alleviate Locomotor Deficits in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06295614), Alleviate gait freezing and instability
- [Esketamine in Microelectrode Recording-guided Subthalamic Deep-Brain Stimulation for Parkinson's Disease（ASPIRE）：A Randomized Controlled, Double-blind Study](https://parkinsonspathways.com/trial/NCT06543563), Preserve brain signals during surgery
- [Influence of Autonomy on Motor Learning in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05960331), Improve upper limb motor learning
- [Effects of Propofol on Brain Function in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05895019), Assess propofol effects on brain
- [Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers in Sleep Dysregulation and Repair](https://parkinsonspathways.com/trial/NCT05070013), Reduce nighttime awakenings with stimulation
- [A Randomized, Double-blind, Multicenter, Placebo-controlled Trial (PRESS-PD)](https://parkinsonspathways.com/trial/NCT06383247), Reduce slowness stiffness and instability
- [Steps Against the Burden of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07058285), Reduce falls with treadmill training
- [A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05292794), Reduce freezing episodes while walking
- [A Multicenter, Sham-controlled, Randomized Study to Evaluate the Safety, Tolerability, and Clinical Responses Following Stereotactic Intracranial Implantation of DSP-1083 Into Subjects With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06753331), Restore dopamine to improve movement
- [REducing SPEECH-related Side-effects of Deep Brain Stimulation in Parkinson's Disease Via Automated Speech Analysis](https://parkinsonspathways.com/trial/NCT05182892), Reduce stimulation induced speech problems
- ["Amazonian Dance for Parkinson": a Protocol Study for a Randomized Clinical Trial on Motor and Non-motor Symptoms of People With Parkinson's.](https://parkinsonspathways.com/trial/NCT06967493), Improve walking through Amazonian dance
- [Implementation of Adaptive DBS to Offset STN Dysregulation During Exercise and Reduce Exertion in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06296810), Prevent symptom worsening during exercise
- [Prospective Study of Constant Current Versus Constant Voltage Deep Brain Stimulation in Patients with Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06742450), Reduce programming and improve symptoms
- [Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease: A Randomized, Double-blind, Sham-controlled Trial](https://parkinsonspathways.com/trial/NCT07118956), Reduce apathy through vagus stimulation
- [Effects of Transcranial Direct Current Stimulation Over the Supplementary Motor Area Combined With Nordic Walking on Gait and Balance in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07381907), Improve walking speed and balance
- [Adaptive/Closed Loop vs. Continuous/Open Loop Deep Brain Stimulation of Subthalamic Nucleus: a Two-Phase, Cross-Over, Double-Blind Trial in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05402163), Test adaptive stimulation for walking
- [A Randomized Controlled Trial of Bilateral Subthalamic Stimulation in Patients With Parkinson's Disease and Impulse Control Disorders](https://parkinsonspathways.com/trial/NCT06498349), Surgical brain stimulation reduces impulsivity
- [Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06899022), Improve attention during brain stimulation
- [Pairing Subjective Patient Rating and Local Field Potentials for DBS Programming](https://parkinsonspathways.com/trial/NCT07336199), Tailor brain stimulation for tremor
- [Impact of a Biophoton Therapy on Patients With Brain Disorders](https://parkinsonspathways.com/trial/NCT06147999), Test biophoton therapy for tremor
- [Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) China Study](https://parkinsonspathways.com/trial/NCT07216976), Testing adaptive stimulation for Parkinson
- [Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06518824), Brain stimulation improves working memory
- [Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease](https://parkinsonspathways.com/trial/NCT05400499), Brain stimulation improves eye alignment
- [Phase I Randomized, Double-blind Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Nucleus Basalis of Meynert or Substantia Nigra for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery](https://parkinsonspathways.com/trial/NCT06683378), Protect substantia nigra dopamine neurons
- [Exploring the Possible Beneficial Impact of Non-invasive and Invasive Neuromodulation on Freezing of Gait in Parkinson's Disease During Different Ambulatory Complexities: An Electrophysiological and fMRI Study](https://parkinsonspathways.com/trial/NCT06505460), Reduce freezing through brain stimulation
- [Deep Brain Stimulation in Parkinson's Disease: Respiratory Testing](https://parkinsonspathways.com/trial/NCT04058457), Brain stimulation changes breathing function
- [Aim 3 Particle Swarm Optimization Postural Instability Gait Disorder](https://parkinsonspathways.com/trial/NCT05934747), Change stimulation to improve balance
- [Frequency-dependent Modulation of Inhibitory Control Via Subthalamic Nucleus Subregional Stimulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07022522), Improve stopping of impulsive actions
- [Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst](https://parkinsonspathways.com/trial/NCT05658302), Studying stimulation signals for symptoms
- [Mechanisms and Effects of Pallidal Deep Brain Stimulation on Levodopa Resistant Motor Signs in Parkinson's Disease; Udall Project 2 Aim 2A&C](https://parkinsonspathways.com/trial/NCT05656586), Can brain stimulation improve walking
- [Overnight Treatment of Parkinson's Disease Using Vestibular Stimulation From a Rocking Bed (Somnomat Casa) - A Feasibility Study](https://parkinsonspathways.com/trial/NCT06386497), Improve sleep using vestibular stimulation
- [Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07348705), Reduce tremor slowness and stiffness
- [Understand Me for Life: Using Noise-augmented Automatic Speech Recognition to Improve Intelligibility in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06540989), Improve speech clarity with feedback
- [Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease (CHAMPION)：A Randomized Controlled, Non-Inferiority Study](https://parkinsonspathways.com/trial/NCT05550714), Confirm tremor control under anesthesia
- [Evaluation of the Cognitive Stimulation Treatment in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06323278), Improve cognitive function with training
- [Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05482126), Improve movement by filtering sensations
- [Understanding Motivation in Parkinson's Patients Through Neurophysiology](https://parkinsonspathways.com/trial/NCT05065151), Brain stimulation improves daily motivation
- [Feasibility, Acceptability, and Effectiveness of an Online Decision Aid for Patients With Parkinson's Disease Considering Deep Brain Stimulation Surgery Using a Pragmatic, Randomized Pilot Trial](https://parkinsonspathways.com/trial/NCT06446505), Testing decision aid for surgery
- [Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease](https://parkinsonspathways.com/trial/NCT06580977), Enhance Parkinsons cognition via exercise
- [Understanding Deep Brain Stimulation-induced Mania: Finding Potential Predictors to Optimize Treatment](https://parkinsonspathways.com/trial/NCT05444907), Prevent mania after brain stimulation
- [Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease - The DREAMS-PD Study](https://parkinsonspathways.com/trial/NCT07110376), Nighttime brain stimulation improves sleep
- [Investigating Neural Biomarkers for Gait in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT05820074), Improve gait using Percept neurostimulation
- [StepuP: Steps Against the Burden of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07057219), Improve walking speed through exercise
- [Investigating Inhibitory Control Networks in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04735458), Improve ability to stop actions
- [Comparing Pain Intensity and Discomfort in Patients With Parkinson´s Disease and Healthy Controls During Inducement of Mechanical, Thermal, and Chemical Experimental Pain](https://parkinsonspathways.com/trial/NCT05981261), Assess experimental pain in Parkinsons
- [Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation](https://parkinsonspathways.com/trial/NCT06951906), Reduce freezing episodes while walking
- [Effect of a 3-week Program of Cane Training and Use on Gait of Individuals With Parkinson's Disease: Protocol for a Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT06950255), Improve gait stability using cane
- [Evaluation De La Performance Clinique D'un Nouveau Biomarqueur Sanguin Des Phases Précoces De La Maladie De Parkinson](https://parkinsonspathways.com/trial/NCT05385315), Blood test detects early Parkinson
- [Neurophysiology of Reward Signaling in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07409207), Improve mood through caudate stimulation
- [Effects of Self-controlled Practice on Motor Learning and Motivation in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07028515), Improve upper limb motor learning
- [Frontosubthalamic Network Dynamics and Their Modulation During Impulse Control and Decision Making in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06485986), Reduce impulsivity through brain stimulation
- [Light Therapy Intervention in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06916260), Improve walking with red light
- [The Effects of Vagus Nerve Stimulation on Intrinsic Lower Leg Spinal Motoneuron Excitability in Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT07226284), Improve gait via vagus nerve
- [Genetics in Parkinson's Disease: Behavioral and Cognitive Outcomes in Patients Undergoing Dopaminergic Treatment](https://parkinsonspathways.com/trial/NCT06329739), Determine if mutation affects thinking
- [Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06405334), Predict falls using wearable sensors
- [Efficacy and Safety of Tenofovir Disoproxil Fumarate in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06356662), Can new drug ease movement
- [Long-Term Behavioral and Cognitive Outcomes of Deep Brain Stimulation in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06329726), How brain stimulation affects thinking
- [Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing](https://parkinsonspathways.com/trial/NCT05818189), Improve walking speed and consistency
- [An Open-label Clinical Trial Investigating the Long-term Safety of Buntanetap in Treating Participants With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07284784), Safety of new Parkinson medication
- [Open-Label Phase 4 Study of CREXONT® (Carbidopa and Levodopa) Extended Release Capsules in Parkinson's Disease Patients](https://parkinsonspathways.com/trial/NCT06765668), Reduce predictable wearing off periods
- [A Multimodal Exercise Program With Gamification (MEP+G) in Individuals With Parkinson Disease: a Pilot Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT06538298), Improve balance using gamified exercise
- [Effect of "Qi-Tonifying, Yang-Warming, and Water-Resolving" Acupuncture and Moxibustion for Motor Symptom Improvement in Early Parkinson's Disease (WARMED): A Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT06874803), Reduce early Parkinsons motor symptoms
- [Sleep-specific DBS Therapy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05962489), Improve sleep with brain stimulation
- [Neurostimulation of the Nucleus Basalis of Meynert for the Cognitive-Motor Syndrome in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05968703), Improve thinking with brain stimulation
- [Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease - UNMC/Medtronic Collaborative Acute Feasibility Pilot](https://parkinsonspathways.com/trial/NCT04799470), Testing brain stimulation for walking
- [Steps Against the Burden of Parkinson's Disease - TelAviv/Bologna](https://parkinsonspathways.com/trial/NCT07105787), Improve walking speed and stability
- [Transcranial Direct Current Stimulation (tDCS) to Improve Motor Function and Motor Fatigue in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT06883266), Reduce movement slowness and fatigue
- [Deep Brain Stimulation Therapy in Movement Disorders](https://parkinsonspathways.com/trial/NCT02119611), Can brain stimulation improve movement
- [Role of Physical Activity on Neuroinflammation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06977204), Lower brain inflammation using exercise
- [A Double-blind Crossover Study to Evaluate the Safety and Efficacy of Adaptive Deep Brain Stimulation Delivered Through AlphaDBS System in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04681534), Testing adaptive stimulation for movement
- [Neuromodulation électrique Continue du Globus Pallidus Dans la Maladie de Parkinson Par l'électrode Directionnelle CARTESIA™](https://parkinsonspathways.com/trial/NCT05626608), Reduce tremor and involuntary movements
- [Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06692920), Map brain signals causing tremor
- [Efficacy of Deep Brain Stimulation and Levodopa on Freezing of Gait in Advanced Parkinson's Disease: a Comparative Study](https://parkinsonspathways.com/trial/NCT06316232), Reduce freezing episodes while walking
- [SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05765110), Speech tracks movement mood thinking
- [Subthalamic and Cortical Electrophysiological Correlates of Motor and Neuropsychiatric Fluctuations in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07404241), Identify signals predicting mood fluctuations
- [Spinal Cord Stimulation for Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06798844), Testing spinal stimulation for freezing
- [Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04650932), Brain stimulation reduces thinking problems
- [Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06911229), Reduce freezing episodes during walking
- [Effect and Mechanism of Deep Brain Stimulation and Transcranial Magnetic Stimulation on Parkinson's Disease With Cognitive Impairment](https://parkinsonspathways.com/trial/NCT06090682), Testing brain stimulation for thinking
- [Effects of Targeted Amino Acid Supplementation for People With Parkinson's Disease on Amino Acid Profiles and Health Related Markers](https://parkinsonspathways.com/trial/NCT07115563), Rebalance neurotransmitter precursors with supplement
- [Cortical Electrophysiology of Response Inhibition in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06234995), Improve stopping of impulsive movements
- [Strength-Endurance Circuit Training in Parkinson's Disease: Effects on Disease Severity, Physical Performance, Blood Biomarkers and Quality of Life.](https://parkinsonspathways.com/trial/NCT06893055), Improve walking balance and strength
- [Theta Burst Subthalamic Nucleus Deep Brain Stimulation for Cognitive and Motor Improvements in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05307055), Improve cognition and motor function
- [Evaluation and Treatment of Neurosurgical Disorders](https://parkinsonspathways.com/trial/NCT00060541), Reduce tremor through neurosurgical evaluation
- [Characterization of Subthalamic Nucleus Deep Brain Stimulation Laterality on Visuospatial Attention and Correlation to Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06994728), Right brain stimulation reduces freezing
- [Unravelling the Neural Mechanisms Underlying Compensation Strategies for Gait Impairments in Parkinson's Disease: a Transnational, Multimodal Approach](https://parkinsonspathways.com/trial/NCT06142448), Improve walking using auditory cueing
- [rTMS as a Cognitive Rehabilitation Approach in Veterans With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT03836950), Improve cognitive function in Parkinsons
- [Mechanism and Application of Deep Brain Stimulation in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06400017), Improve memory with brain stimulation
- [Stimulation of the External Pallidal Segment for Insomnia in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04116996), Improve insomnia with pallidal stimulation
- [Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control](https://parkinsonspathways.com/trial/NCT06013956), Brain stimulation improves movement speed
- [Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders](https://parkinsonspathways.com/trial/NCT04061135), Can brain recordings explain movement
- [Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry](https://parkinsonspathways.com/trial/NCT02071134), Testing Vercise system for symptoms
- [Randomized Controlled Trial Comparing Adaptive Versus Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06909045), Increase daily good movement hours
- [Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD](https://parkinsonspathways.com/trial/NCT06169852), Optimize brain stimulation for movement
- [Genetics and Aerobic Exercise to Slow Parkinson's Disease (GEARS) Trial](https://parkinsonspathways.com/trial/NCT06442033), Can cycling slow Parkinson progression
- [Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects](https://parkinsonspathways.com/trial/NCT04735172), Detect early brain chemical changes
- [Physiological Brain Atlas Development](https://parkinsonspathways.com/trial/NCT00575081), Improve targeting for brain stimulation
- [Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT06791902), Reduce freezing and improve walking
- [Short- and Long-term Behavioral, Cognitive and Motor Outcomes of Frameless Deep Brain Stimulation in Patients With Parkinson's Disease: a Prospective Observational Study](https://parkinsonspathways.com/trial/NCT05752656), Reduce tremor using brain stimulation

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)