---
title: "GBA1 Parkinson's Clinical Trials | Parkinson's Pathways"
description: "Recruiting clinical trials for people with GBA1 (GBA) gene changes linked to Parkinson's. See enrolling studies, including genetic-specific therapies, and get notified of new trials."
canonical_url: "https://parkinsonspathways.com/trials/pathway/gba1"
topic_type: pathway
source: "Parkinson's Pathways"
---
# Clinical Trials for GBA1 Parkinson's

Changes in the GBA1 gene (often just called GBA) are among the most common genetic risk factors for Parkinson's. They affect an enzyme called glucocerebrosidase, which helps brain cells clear waste, and several treatments now in trials aim to boost that enzyme's activity.

Some of these studies enroll only people with a confirmed GBA1 change, while others test drugs — such as ambroxol — designed to work through this pathway. Knowing your genetic status can open the door to trials that would not otherwise be available.

Below are the recruiting trials we track that involve GBA1 Parkinson's. Sign up to be emailed when a new one opens.

## 11 recruiting trials

- [Evaluation of the Safety and Feasibility of a Single Transplantation of 10 Million Human Embryonic Stem Cell-Derived Dopaminergic Progenitor Cells Into the Bilateral Striatum of Patients With Moderately Severe Parkinson's Disease: a Multicenter, Open-label, Single-arm Phase I Clinical Trial](https://parkinsonspathways.com/trial/NCT07572071) — Improve walking and reduce stiffness
- [Study on the Incidence of Malignant Neoplasms in Patients with Parkinson's Disease and Heterozygous Mutation of the GBA Gene](https://parkinsonspathways.com/trial/NCT06814431) — Determine cancer risk in Parkinson
- [The Chinese Parkinson's Disease With GBA Variants Registry](https://parkinsonspathways.com/trial/NCT03523065) — Predict symptoms and personalize care
- [A Phase I/II Study for Bilateral Putamenal Delivery of Recombinant Glucocerebrosidase in Patients With Parkinson's Disease Using MR-guided Focused Ultrasound Induced Opening of the Blood-brain Barrier](https://parkinsonspathways.com/trial/NCT05565443) — Restore glucocerebrosidase activity in putamen
- [Drug Discovery for Parkinson's With Mutations in the GBA Gene](https://parkinsonspathways.com/trial/NCT05536388) — Find drugs boosting cell cleanup
- [D-SPARK: A Randomized Double Blind Clinical Trial of D-Serine for Modifying Parkinson's Disease Progression](https://parkinsonspathways.com/trial/NCT07312110) — Slow Parkinson degeneration using Dserine
- [Etude Des Facteurs Prédictifs De L'apparition Et De L'évolution De La Maladie De Parkinson](https://parkinsonspathways.com/trial/NCT02305147) — Identify markers predicting Parkinson progression
- [An Open-label Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GT-02287 in Participants With Parkinson's Disease With or Without a Pathogenic GBA1 Mutation](https://parkinsonspathways.com/trial/NCT06732180) — New drug slows Parkinson progression
- [PD Frontline, Part of RAPSODI GD (Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher's Disease) to Build an Online Trial-ready Cohort of GBA Genotyped People With Parkinson's](https://parkinsonspathways.com/trial/NCT06151002) — Identify candidates for gene therapy
- [The Parkinson's Progression Markers Initiative (PPMI) Clinical - Establishing a Deeply Phenotyped PD Cohort](https://parkinsonspathways.com/trial/NCT04477785) — Identify tests predicting Parkinson progression
- [Multimodal Molecular Imaging and Biometric Analysis in GBA-PD and Asymptomatic GBA-mutation Carriers](https://parkinsonspathways.com/trial/NCT04101968) — Detect early Parkinson brain changes

## Related topics

- [LRRK2 Parkinson's](https://parkinsonspathways.com/trials/pathway/lrrk2)
- [Ambroxol](https://parkinsonspathways.com/trials/drug/ambroxol)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)