---
title: "Clinical Trials for Newly Diagnosed Parkinson's | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials open to people who were recently diagnosed or are in the earliest stages. See enrolling studies and get notified when a new one opens."
canonical_url: "https://parkinsonspathways.com/trials/pathway/newly-diagnosed"
topic_type: pathway
source: "Parkinson's Pathways"
---
# Clinical Trials for Newly Diagnosed Parkinson's

Being newly diagnosed with Parkinson's is overwhelming, but it is also the stage when the most clinical trials are open to you. Many disease-modifying studies — the ones testing whether a treatment can slow Parkinson's down — specifically look for people in the first few years after diagnosis, before symptoms have advanced.

These trials often use phrases like "early-stage", "de novo", "newly diagnosed", or "within 2 years of diagnosis" in who they can enroll. Some also look for people who have not yet started medication, which we track on a separate page.

Below are the recruiting trials we track that are open to people in the early stages of Parkinson's. Sign up to be emailed when a new one opens.

## 56 recruiting trials

- [Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage Parkinson's Disease Patient](https://parkinsonspathways.com/trial/NCT07619560) — Probiotic cocktail delays Parkinson progression
- [Investigation of the Relationship Between Sleep Quality, Cognitive Functions, and Disease Severity in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07536490) — Determine if sleep affects thinking
- [Effects of Dual-Task Training on Upper Extremity Function and Muscle Thickness in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07536542) — Multitasking exercises improve arm strength
- [Exoskeleton-Assisted Mobility in Aging and in Parkinson's Disease: A Mixed-Methods Study of Effectiveness and Acceptability](https://parkinsonspathways.com/trial/NCT07567482) — Exoskeleton improves balance while walking
- [The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease: A Three-arm, Randomized, Double-blind, Parallel-controlled Study](https://parkinsonspathways.com/trial/NCT07572903) — Reduce tremor and movement stiffness
- [Changes in Motor Function, Quality of Life, Cardiorespiratory Fitness, and Physiological Markers in People With Parkinson's Disease Following Different Exercise Interventions.](https://parkinsonspathways.com/trial/NCT07221266) — Improve walking endurance through exercise
- [A Single-Center, Double-Blind Randomized Controlled Trial of Accelerated Temporal Interference Stimulation Applied to Bilateral Subthalamic Nucleus for Improving Motor and Vocal Functions in Patients With Parkinson's Disease Or Secondary Parkinson's Syndrome](https://parkinsonspathways.com/trial/NCT07568067) — Improve movement and speech function
- [BioFINDER-Sleep: Idiopathic REM-sleep Behavior Disorder & Early Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07533799) — Find tests predicting Parkinson progression
- [Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease: Protocol For a Double Blind Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07518290) — Home brain stimulation improves walking
- [A Phase 2, Randomized, Double-blind, Placebo-Controlled, Single-Center Study to Assess the Effects of SUL-238 on High Energy Phosphates With Magnetic Resonance Spectroscopy (³¹P-MRS) in Patients With Early, Untreated Parkinson's Disease ("SHEPHERD" STUDY)](https://parkinsonspathways.com/trial/NCT07322887) — New medication improves brain energy
- [The Effect of Motor Imagery Added to Conventional Rehabilitation on Balance and Kinesiophobia in Patients With Parkinson's Disease: A Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07495462) — Improve balance through mental rehearsal
- [Study for the Dual Orexin Receptor Antagonist Lemborexant in Improving Motor-Sleep Comorbidity in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07384429) — Lemborexant improves motor and sleep
- [Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07488026) — Reduce freezing episodes while walking
- [Exergaming With Physical Objects for Upper Limb Rehabilitation in Parkinson's Disease: Effects on Functional Outcome](https://parkinsonspathways.com/trial/NCT07475741) — Improve hand dexterity with phygital
- [Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06416345) — Wearable cues reduce daily freezing
- [IMPACT 360 Study for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07443293) — Slow Parkinson progression through lifestyle
- [Assistive Robotic in the Elderly: Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological Innovation](https://parkinsonspathways.com/trial/NCT04087031) — Improve walking with robotic treadmill
- [Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in Parkinson's Disease R01 HD100670](https://parkinsonspathways.com/trial/NCT04796506) — Improve cognition via resistance training
- [A Study on the Safety, Tolerability, and Efficacy of PDR-001 Injection for Bilateral Stereotactic Subthalamic Nucleus (STN) Clearance of α-synuclein](https://parkinsonspathways.com/trial/NCT07157345) — Brain injection clears sticky protein
- [A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early-Stage Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07174310) — New medication slows early progression
- [Research on the Brain Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Regulating PD Motor Symptoms](https://parkinsonspathways.com/trial/NCT06409338) — Gentle ear stimulation improves movement
- [Home Telerehabilitation Based on Serious Games for Continuity of Care in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05773885) — Improve balance using telerehabilitation games
- [A Novel Accessible and Widespread Healthcare Service Model Based on Technology Innovation for Objective (Early) Diagnosis and Therapeutic Monitoring of Parkinson's Disease Promoting Continuity of Care](https://parkinsonspathways.com/trial/NCT06907589) — Detect subtle walking changes early
- [Effectiveness of a Robotic End-effector Device for Upper Limb Rehabilitation in People With Parkinson's Disease: a Multicenter Randomized Controlled Pilot Study](https://parkinsonspathways.com/trial/NCT06906679) — Improve arm dexterity with robotics
- [Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease](https://parkinsonspathways.com/trial/NCT05400499) — Improve vision guided reaching ability
- [A Phase I/II Study for Bilateral Putamenal Delivery of Recombinant Glucocerebrosidase in Patients With Parkinson's Disease Using MR-guided Focused Ultrasound Induced Opening of the Blood-brain Barrier](https://parkinsonspathways.com/trial/NCT05565443) — Restore glucocerebrosidase activity in putamen
- [The Chinese DENOVO Parkinson's Disease Registry](https://parkinsonspathways.com/trial/NCT05767151) — Track early Parkinson disease progression
- [A Randomized, Double-blind (Sponsor-unblinded), Placebo-controlled, Single-ascending-dose Study in Healthy Volunteers and a Double-blind (Sponsor-unblinded), Placebo-controlled, Multiple-ascending-dose Study in Patients With Parkinson's Disease to Evaluate the Safety, Tolerability, and PK/PD of LY3962681](https://parkinsonspathways.com/trial/NCT06565195) — Reduce toxic brain protein clumps
- [A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study and Open-Label Extension to Evaluate the Safety and Efficacy of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease (NEULARK)](https://parkinsonspathways.com/trial/NCT06680830) — Slow early Parkinson disease progression
- [The Effect of Exercise Intervention on Posture, Trunk Flexibility and Spine Function in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06536478) — Improve posture and trunk flexibility
- [Effects Of Osteopathic Manipulative Medicine(OMM) On Lower Extremity Muscle Characteristics In Parkinson's Disease(PD) Patients](https://parkinsonspathways.com/trial/NCT05884944) — Reduce lower extremity muscle stiffness
- [Evaluation De La Performance Clinique D'un Nouveau Biomarqueur Sanguin Des Phases Précoces De La Maladie De Parkinson](https://parkinsonspathways.com/trial/NCT05385315) — Detect early Parkinson via blood
- [Influence of Glucose on Metabolism and Clinical Symptoms of Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05998772) — Improve motor symptoms via glucose
- [Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06405334) — Predict falls by mapping movements
- [The Effects of 24 Weeks Community-based Brisk Walking on Physical Function, Comorbidities, Cognition, Disease Severity, and Health-related Quality of Life in People With Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06707402) — Increase walking speed and endurance
- [A Randomized Double-blind Placebo-controlled Multicentre Study to Assess Safety, Tolerability, Pharmacokinetics and Efficacy of Radotinib in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04691661) — Test radotinib to slow progression
- [Molecular Imaging of LPS-induced Microglial Activation in Parkinson's Disease (PD). A TSPO PET-MR Imaging Study](https://parkinsonspathways.com/trial/NCT05205291) — Map Parkinson brain immune activity
- [Effectiveness of a High-intensity Functional Training (HIFT) Program on Functional and Cognitive Performance in People with Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06879821) — Improve everyday movement and thinking
- [Blood Flow Restriction for Optimizing Balance in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06508801) — Reduce falls by improving balance
- [A Double-blind Crossover Study to Evaluate the Safety and Efficacy of Adaptive Deep Brain Stimulation Delivered Through AlphaDBS System in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04681534) — Reduce tremor slowness and stiffness
- [Clinical Study Evaluating the Possible Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07001150) — Silymarin slows Parkinson disease progression
- [Caregiver Burden and Associated Factors in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06892717) — Improve walking reduce caregiver burden
- [Management of Initial Parkinson's Disease: a Prospective, Mono-centric, no Profit Pilot Clinical Trial Comparing Conventional Face-to-face Physiotherapy and Home-based Telerehabilitation](https://parkinsonspathways.com/trial/NCT06052280) — Improve gait and balance remotely
- [Effect of Action Observation and Motor Imagery Therapy on Balance, Functional Status and Quality of Life in Parkinson's Disease, Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT06154356) — Improve balance with motor imagery
- [Biochemical Characterization of Parkinson's Disease-related Proteins in the Enteric Nervous System as a Proxy for Pathological Changes in the Brain](https://parkinsonspathways.com/trial/NCT05347407) — Detect Parkinson using gut biopsy
- [Clinical Study on Non-Invasive Fundus Retinal Detection Technology for Early Diagnosis of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07244640) — Retinal imaging detects early Parkinson
- [Plasticity of Motor Systems in Early Stage Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05286736) — Identify motor plasticity affecting walking
- [Video-oculography and Parkinson's Disease: A Prospective Study](https://parkinsonspathways.com/trial/NCT04731246) — Detect early Parkinsons via oculography
- [A Phase 1/2 Study to Evaluate Safety, PK and Biodistribution of an Imaging Agent, 18F-OP-801, After Intravenous Administration to Patients With ALS, Alzheimer's Disease, Multiple Sclerosis, Parkinson's Disease and Healthy Volunteers](https://parkinsonspathways.com/trial/NCT05395624) — Brain scan detects immune activity
- [Acute Treatment of Parkinson's Disease With Gamma Frequency Stimulation](https://parkinsonspathways.com/trial/NCT05268887) — Reduce slowness stiffness and tremor
- [Comparing the Effectiveness of Online Self-management Program and On-site Task-related Training for People With Early Stage Parkinson's Disease on Activity Participation and Quality of Life](https://parkinsonspathways.com/trial/NCT06248073) — Increase participation in daily activities
- [Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving Rapid Eye Movement Behavior Disorder with Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06710574) — Probiotics reduce acting out dreams
- [Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD](https://parkinsonspathways.com/trial/NCT06169852) — Reduce tremor stiffness and slowness
- [The Effect of Long-term Treatment of Parkinson's Disease With T-PEMF](https://parkinsonspathways.com/trial/NCT07306104) — Magnetic pulses reduce movement stiffness
- [Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects](https://parkinsonspathways.com/trial/NCT04735172) — Identify early striatal metabolite changes
- [Machine Learning Analysis Of The Tapping Test And The Archimedean Spiral For The Differential Diagnosis Of Essential Tremor And Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06378619) — Distinguish essential tremor from Parkinsons

## Related topics

- [Not Yet on Medication](https://parkinsonspathways.com/trials/pathway/no-meds-required)
- [Prasinezumab](https://parkinsonspathways.com/trials/drug/prasinezumab)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)