---
title: "Parkinson's Trials for People Not Yet on Medication | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials open to people who have not yet started levodopa or other Parkinson's drugs. See enrolling studies and get notified of new trials."
canonical_url: "https://parkinsonspathways.com/trials/pathway/no-meds-required"
topic_type: pathway
source: "Parkinson's Pathways"
---
# Clinical Trials for People Not Yet on Parkinson's Medication

Some Parkinson's trials specifically enroll people who have not yet started medication — often called "levodopa-naïve", "treatment-naïve", or "untreated". Researchers look for this group because it lets them measure a new treatment's effect without the influence of existing Parkinson's drugs.

If you have recently been diagnosed and are still deciding when to begin treatment, these studies may be especially relevant. Taking part does not usually mean going without care — many trials still allow you to start standard medication if and when you need it.

Below are the recruiting trials we track that are open to people not yet on Parkinson's medication. Sign up to be emailed when a new one opens.

## 34 recruiting trials

- [Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07207122) — Sound waves reduce movement stiffness
- [Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.](https://parkinsonspathways.com/trial/NCT07398157) — Personalize brain stimulation for movement
- [BioFINDER-Sleep: Idiopathic REM-sleep Behavior Disorder & Early Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07533799) — Find tests predicting Parkinson progression
- [A Phase 2, Randomized, Double-blind, Placebo-Controlled, Single-Center Study to Assess the Effects of SUL-238 on High Energy Phosphates With Magnetic Resonance Spectroscopy (³¹P-MRS) in Patients With Early, Untreated Parkinson's Disease ("SHEPHERD" STUDY)](https://parkinsonspathways.com/trial/NCT07322887) — New medication improves brain energy
- [Study for the Dual Orexin Receptor Antagonist Lemborexant in Improving Motor-Sleep Comorbidity in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07384429) — Lemborexant improves motor and sleep
- [A Natural History Study of Treated Parkinson's Disease Patients Experiencing Motor Complications](https://parkinsonspathways.com/trial/NCT07330258) — Document motor complications despite medication
- [A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Feasibility, and Preliminary Efficacy of NouvNeu001 in Patients With Advanced Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT07102342) — Cell transplant improves motor symptoms
- [Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease](https://parkinsonspathways.com/trial/NCT04396873) — Image brain cyclooxygenase related inflammation
- [Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in Parkinson's Disease R01 HD100670](https://parkinsonspathways.com/trial/NCT04796506) — Improve cognition via resistance training
- [Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers in Sleep Dysregulation and Repair](https://parkinsonspathways.com/trial/NCT05070013) — Sensing brain stimulation lengthens sleep
- [Impact of a Biophoton Therapy on Patients With Brain Disorders](https://parkinsonspathways.com/trial/NCT06147999) — Test biophoton therapy for tremor
- [Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease](https://parkinsonspathways.com/trial/NCT05400499) — Improve vision guided reaching ability
- [The Chinese DENOVO Parkinson's Disease Registry](https://parkinsonspathways.com/trial/NCT05767151) — Track early Parkinson disease progression
- [Analysis of the Relationship Between Immunosuppressive Treatment Status and Clinical Course of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06834191) — Determine whether immunosuppression slows progression
- [A Prospective, Single-center, Single-arm, Exploratory, 24-Month Study to Confirm Efficacy of Modified Deep Cervical Lymphovenous Anastomosis (LVA) in Subjects With Alzheimer's Disease/ Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06852352) — Surgery to reduce protein buildup
- [A Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4006896 in Healthy Participants and Participants With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06809400) — Test new antibody slows progression
- [Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease - The DREAMS-PD Study](https://parkinsonspathways.com/trial/NCT07110376) — Improve sleep using brain pulses
- [Comparing Pain Intensity and Discomfort in Patients With Parkinson´s Disease and Healthy Controls During Inducement of Mechanical, Thermal, and Chemical Experimental Pain](https://parkinsonspathways.com/trial/NCT05981261) — Assess experimental pain in Parkinsons
- [Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06088355) — Increase walking endurance through exercise
- [Molecular Imaging of LPS-induced Microglial Activation in Parkinson's Disease (PD). A TSPO PET-MR Imaging Study](https://parkinsonspathways.com/trial/NCT05205291) — Map Parkinson brain immune activity
- [An Open-label Clinical Trial Investigating the Long-term Safety of Buntanetap in Treating Participants With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07284784) — Assess long term buntanetap safety
- [Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment](https://parkinsonspathways.com/trial/NCT06688968) — Measure emotional response to music
- [Neurostimulation of the Nucleus Basalis of Meynert for the Cognitive-Motor Syndrome in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05968703) — Improve attention memory and walking
- [Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease - UNMC/Medtronic Collaborative Acute Feasibility Pilot](https://parkinsonspathways.com/trial/NCT04799470) — Brain stimulation improves motor control
- [Using Biofeedback During Exergaming to Attenuate Alpha Oscillations to Improve Postural Control in People Living With Parkinson's.](https://parkinsonspathways.com/trial/NCT05986643) — Improve balance using neurofeedback exergaming
- [CSP #2015 - Multicenter, Randomized, Double-blind Comparator Study of Antipsychotics Pimavanserin and Quetiapine for Parkinson''s Disease Psychosis (C-SAPP)](https://parkinsonspathways.com/trial/NCT04373317) — Reduce hallucinations without worsening movement
- [Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05298150) — Reduce freezing with dynamic cycling
- [Biochemical Characterization of Parkinson's Disease-related Proteins in the Enteric Nervous System as a Proxy for Pathological Changes in the Brain](https://parkinsonspathways.com/trial/NCT05347407) — Detect Parkinson using gut biopsy
- [Efficacy and Safety of Entacapone Combined With Madopar in the Treatment of Early Parkinson's Disease: An Observational, Multicenter, Case-Control Study](https://parkinsonspathways.com/trial/NCT06928519) — Reduce medication wearing off fluctuations
- [Plasticity of Motor Systems in Early Stage Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05286736) — Identify motor plasticity affecting walking
- [A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Participants and in Participants With Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06466525) — Test drug safety in Parkinson
- [The Effects of Different Exercise Modalities on Sleep Quality and Architecture in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05644327) — Improve sleep quality through exercise
- [Stimulation of the External Pallidal Segment for Insomnia in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04116996) — Improve insomnia with pallidal stimulation
- [Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects](https://parkinsonspathways.com/trial/NCT04735172) — Identify early striatal metabolite changes

## Related topics

- [Newly Diagnosed](https://parkinsonspathways.com/trials/pathway/newly-diagnosed)
- [Prasinezumab](https://parkinsonspathways.com/trials/drug/prasinezumab)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)