--- title: "Stem-Cell Therapy Parkinson's Clinical Trials | Parkinson's Pathways" description: "Recruiting clinical trials studying stem-cell and cell-replacement therapies for Parkinson's disease. See enrolling studies and get notified when a new trial opens." canonical_url: "https://parkinsonspathways.com/trials/pathway/stem-cell" topic_type: pathway source: "Parkinson's Pathways" --- # Stem-Cell and Cell Therapy Clinical Trials for Parkinson's Stem-cell therapy is one of the most talked-about frontiers in Parkinson's research. The idea is to replace the dopamine-producing brain cells lost to the disease using new cells grown from stem cells, rather than only compensating for the dopamine that is missing. These are early-stage, surgical studies focused first on safety and on whether the transplanted cells survive and work. They are a fundamentally different approach from a pill, and the field is moving quickly. Below are the recruiting trials we track that involve stem-cell or cell-replacement therapy. Sign up to be emailed when a new one opens. ## 20 recruiting trials - [Evaluation of the Safety and Feasibility of a Single Transplantation of 10 Million Human Embryonic Stem Cell-Derived Dopaminergic Progenitor Cells Into the Bilateral Striatum of Patients With Moderately Severe Parkinson's Disease: a Multicenter, Open-label, Single-arm Phase I Clinical Trial](https://parkinsonspathways.com/trial/NCT07572071) — Improve walking and reduce stiffness - [Implementing a National Biobank of Genetic, Sporadic and Prodromic Parkinson's Disease With Whole Genome Analysis and Functional Assessment of Polygenic Inheritance by iPSC Technology](https://parkinsonspathways.com/trial/NCT05721911) — Identify genetic causes of Parkinson - [A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Feasibility, and Preliminary Efficacy of NouvNeu001 in Patients With Advanced Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT07102342) — Cell transplant improves motor symptoms - [Phase I Trial of Autologous Induced Pluripotent Stem Cell-derived Dopaminergic Progenitor Cell Transplantation for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06687837) — Cell implant reduces off time - [A Multicenter, Sham-controlled, Randomized Study to Evaluate the Safety, Tolerability, and Clinical Responses Following Stereotactic Intracranial Implantation of DSP-1083 Into Subjects With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06753331) — Restore dopamine to improve movement - [Safety and Efficacy of Autologous Induced Neural Stem Cell-derived Dopaminergic Precursor Cells in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05901818) — Restore dopamine to improve walking - [A Single-arm, Open-label, Single-dose Clinical Study to Evaluate the Safety and Tolerability of BBM-P002 for Stereotactic Bilateral Putamen Injection in the Treatment of Idiopathic Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07195825) — Brain injection reduces movement problems - [A Phase I Study to Assess the Safety, Tolerability and Preliminary Efficacy of NouvNeu001 Injection in the Treatment of Early-onset Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06608355) — Replace lost dopamine producing neurons - [A Clinical Trial of Parkinson's Disease Treatment by Human-induced Pluripotent Stem Cells (hiPSCs) Derived Dopaminergic Neural Precursor Cells](https://parkinsonspathways.com/trial/NCT06145711) — Reduce medication wearing off symptoms - [A Phase I/II Study to Assess the Safety, Tolerability and Efficacy of NouvNeu001 Injection for Mid- to Late-stage Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06167681) — Replace lost dopamine producing neurons - [A Phase I, Open Label, Single Arm, Dose Escalation and Dose Expansion Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of Human Induced Pluripotent Stem Cell Derived Dopaminergic Progenitor Cells (NCR201) Injection in the Treatment of Subjects With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06978920) — Donor cell injections reduce tremor - [A Phase 1b/2a Study Assessing the Safety and Efficacy of Intraputamenal Dopaminergic Stem Cell Transplants in Patients With Idiopathic Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07106021) — Restore dopamine production in putamen - [A Single-Center, Open-Label, Single-Arm Exploratory Study Evaluating GM101 Injection in Patients With Mid-to-Late Stage Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07100171) — Gene therapy improves motor control - [Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Exosome Intranasal Instillation for the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05152394) — Assess intranasal AlloEx exosome safety - [A Phase I Clinical Study on the Safety and Tolerability of iPSC-Derived Dopaminergic Neural Progenitor Cell Injection Via Stereotaxic Brain Transplantation for the Treatment of Primary Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07080775) — Cell transplant reduces off time - [NYSCF Scientific Discovery Biobank](https://parkinsonspathways.com/trial/NCT06203106) — Enable new Parkinson treatment development - [exPDite-2: A Phase 3 Study to Assess the Efficacy and Safety of Midbrain Dopaminergic Neuronal Cell Therapy (Bemdaneprocel) for Participants With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06944522) — Reduce daily off medication time - [A Phase I/II Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of Human Allogeneic Induced Pluripotent Stem Cell-derived Dopaminergic Neural Progenitor Cell Injection in the Treatment of Early-onset Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07166757) — Reduce off period motor fluctuations - [An Investigator-initiated Clinical Trial of Safety and Efficacy of Transplantation of Human Induced Pluripotent Stem Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II)](https://parkinsonspathways.com/trial/NCT06482268) — Transplant restores dopamine producing cells - [Derivation of Induced Pluripotent Stem Cells from Somatic Cells Donated by Patients with Neurological Diseases for the Study of the Pathogenesis of the Disorders and Development of Novel Therapies](https://parkinsonspathways.com/trial/NCT00874783) — Create personalized stem cell therapies ## Related topics - [Bemdaneprocel](https://parkinsonspathways.com/trials/drug/bemdaneprocel) - [Newly Diagnosed](https://parkinsonspathways.com/trials/pathway/newly-diagnosed) ## Related - [Browse all recruiting trials](https://parkinsonspathways.com/trials) - [Match yourself to relevant trials](https://parkinsonspathways.com/match) - [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)