---
title: "Clinical Trials for Parkinson's Cognition and Memory | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials studying cognition, memory, and dementia. See enrolling studies and get an email when a new trial opens."
canonical_url: "https://parkinsonspathways.com/trials/symptom/cognition"
topic_type: symptom
source: "Parkinson's Pathways"
---
# Clinical Trials for Parkinson's Cognition and Memory

Cognitive changes, from mild slowing to Parkinson's disease dementia, are a real concern for many families. There are more clinical trials looking at this than most people realize, and they cover a wide range of approaches.

Studies include new medications targeting cognitive decline, repurposed drugs originally developed for Alzheimer's disease, exercise-based programs, and observational studies that track cognition over years to identify early predictors.

Below are the recruiting trials we track that focus on cognition and memory. Sign up to be emailed when a new one opens.

## 277 recruiting trials

- [Feasibility and Preliminary Effectiveness of an Individualized Multimodal Group-Based Exercise Programme for People With Parkinson's Disease: A Non-Randomized Feasibility Study](https://parkinsonspathways.com/trial/NCT07618728) — Improve walking stability with exercise
- [Investigation of the Relationship Between Sleep Quality, Cognitive Functions, and Disease Severity in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07536490) — Determine if sleep affects thinking
- [Effects of Dual-Task Training on Upper Extremity Function and Muscle Thickness in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07536542) — Multitasking exercises improve arm strength
- [Effects of Trunk Control Exercises and Mirror Therapy on Balance and Posture in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07610031) — Improve trunk posture and balance
- [Zesty Exercise System for Therapeutic Engagement](https://parkinsonspathways.com/trial/NCT07382674) — Improve standing reach and strength
- [Biomechanical Effects of Expiratory Muscle Strength Training (EMST®) on Swallowing Function in Parkinson's Disease - a Prospective High-resolution Manometry Study](https://parkinsonspathways.com/trial/NCT07606547) — Improve swallowing through breath training
- [Comparative Effects of Robot-Assisted Gait Training and Quadriceps Neuromuscular Electrical Stimulation Added to Standard Exercise Rehabilitation on Balance, Gait, Disease Severity, and Quadriceps Muscle Adaptations in Patients With Parkinson Disease: A Prospective Randomized Assessor-Blinded Clinical Trial](https://parkinsonspathways.com/trial/NCT07589296) — Improve walking speed and balance
- [Exoskeleton-Assisted Mobility in Aging and in Parkinson's Disease: A Mixed-Methods Study of Effectiveness and Acceptability](https://parkinsonspathways.com/trial/NCT07567482) — Exoskeleton improves balance while walking
- [Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07207122) — Sound waves reduce movement stiffness
- [Evaluation of the Safety and Feasibility of a Single Transplantation of 10 Million Human Embryonic Stem Cell-Derived Dopaminergic Progenitor Cells Into the Bilateral Striatum of Patients With Moderately Severe Parkinson's Disease: a Multicenter, Open-label, Single-arm Phase I Clinical Trial](https://parkinsonspathways.com/trial/NCT07572071) — Improve walking and reduce stiffness
- [Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.](https://parkinsonspathways.com/trial/NCT07398157) — Personalize brain stimulation for movement
- [A Single-Center, Double-Blind Randomized Controlled Trial of Accelerated Temporal Interference Stimulation Applied to Bilateral Subthalamic Nucleus for Improving Motor and Vocal Functions in Patients With Parkinson's Disease Or Secondary Parkinson's Syndrome](https://parkinsonspathways.com/trial/NCT07568067) — Improve movement and speech function
- [Transcranial Direct Current Stimulation Treatment of Cognitive Dysfunction in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT03025334) — Brain stimulation improves thinking skills
- [Non-pharmacological Enhancement of Deep Sleep With Auditory Stimulation Versus Sham in People With Parkinson's Disease and Mild Cognitive Impairment Receiving Cognitive Training: A Double-blind Randomized Trial (PD-CogT-Sleep)](https://parkinsonspathways.com/trial/NCT07441915) — Improve deep sleep and thinking
- [Using taVNS to Modulate Cardiovascular Function in Individuals With Neurologic Disease](https://parkinsonspathways.com/trial/NCT07557706) — Ear stimulation reduces standing lightheadedness
- [A Pilot Study of In-lab Dynamic Standing in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07543861) — Improve walking with dynamic standing
- [Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease: Protocol For a Double Blind Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07518290) — Home brain stimulation improves walking
- [COMPARATIVE EFFECTIVENESS of COLLABORATIVE VIRTUAL ENVIRONMENT and NON-IMMERSIVE VIRTUAL REALITY in the REHABILITATION of PATIENTS With PARKINSON'S DISEASE](https://parkinsonspathways.com/trial/NCT07523425) — Collaborative virtual reality improves walking
- [Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07478146) — Exercise improves walking and thinking
- [Effects of the Combination of Physical Exercise and Transcranial Direct Current Stimulation on Motor Function and Underlying Neurophysiological Mechanisms in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07524400) — Improve movement with brain stimulation
- [Brain Glutathione (GSH) Enrichment Through Gamma-glutamylcysteine (GGC) Supplementation in Early Parkinson's Disease Patients for Reduction of Extrapyramidal Motor Disturbances and Halting Cognition Decline: A Pilot Trial](https://parkinsonspathways.com/trial/NCT07064005) — Reduce movement problems with supplement
- [The Effect of MRI-Guided Transcranial Direct Current Stimulation on Cognitive and Affective Symptoms in Persons With Parkinson's Disease and Controls](https://parkinsonspathways.com/trial/NCT06467695) — Targeted brain stimulation reduces depression
- [Ultra-High Resolution PET of the Human Brain and Spinal Cord in Healthy Aging, Dementia, Movement Disorders, ALS and Psychotic Disorders](https://parkinsonspathways.com/trial/NCT07509125) — Distinguish Parkinson from related disorders
- [Implementing a National Biobank of Genetic, Sporadic and Prodromic Parkinson's Disease With Whole Genome Analysis and Functional Assessment of Polygenic Inheritance by iPSC Technology](https://parkinsonspathways.com/trial/NCT05721911) — Identify genetic causes of Parkinson
- [Adapting High-Intensity Exercise and Sleep Monitoring Technology for Home Use in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07498296) — Build strength and improve walking
- [Accelerated Transcranial Magnetic Stimulation (TMS) for Apathy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07399496) — Reduce apathy and boost motivation
- [Dose-Escalation, Single-Center, Open-label Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of Adeno-associated Virus(AAV) Gene Therapy Product IPS101A in Parkinson's Disease Patients With Hoehn-Yahr Stage 4-5, Diagnosed in More Than 10 Years and Uncontrolled by All Available Monotherapy or Combination Therapy](https://parkinsonspathways.com/trial/NCT07371338) — Reduce medication resistant motor symptoms
- [Study for the Dual Orexin Receptor Antagonist Lemborexant in Improving Motor-Sleep Comorbidity in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07384429) — Lemborexant improves motor and sleep
- [Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07488026) — Reduce freezing episodes while walking
- [Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05568498) — Treat Parkinson depression with probiotics
- [Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients](https://parkinsonspathways.com/trial/NCT07384442) — Reduce tremor and improve gait
- [The Role of a Personalized Music Intervention Towards Alleviating Apathy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05505019) — Reduce apathy through personalized music
- [Safety, Tolerability and Symptomatic Efficacy of the ROCK-Inhibitor Fasudil in Patients With Parkinson's Disease (ROCK-PD)](https://parkinsonspathways.com/trial/NCT05931575) — Reduce motor symptoms with fasudil
- [Exergaming With Physical Objects for Upper Limb Rehabilitation in Parkinson's Disease: Effects on Functional Outcome](https://parkinsonspathways.com/trial/NCT07475741) — Improve hand dexterity with phygital
- [Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06416345) — Wearable cues reduce daily freezing
- [Motor and Cognitive Exercise in Parkinson's Disease. A Feasibility Randomized Clinical Trial](https://parkinsonspathways.com/trial/NCT07465107) — Improve gait balance and attention
- [NEUROTECHNO: Precision Medicine and Neurodegenerative Diseases: Advanced Systems for the Diagnosis and Treatment of Parkinson's Disease and Alzheimer's Disease.](https://parkinsonspathways.com/trial/NCT07467460) — Early detection slows Parkinson progression
- [Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07151378) — Smooth motor and behavioral fluctuations
- [FREEZE-Path Cohort: Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)](https://parkinsonspathways.com/trial/NCT07386015) — Predict falls due to freezing
- [A Phase 1b, Prospective, Randomized, Double-blind, Placebo-controlled Trial Evaluating the Safety and Tolerability of Multiple Oral Doses of IRL757 in Participants With Parkinson's Disease and Apathy](https://parkinsonspathways.com/trial/NCT07461220) — New medication restores daily motivation
- [Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients](https://parkinsonspathways.com/trial/NCT07455760) — Improve speech sequencing using stimulation
- [Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases](https://parkinsonspathways.com/trial/NCT07449117) — Improve language processing and behavior
- [The Influence of Vibrotactile Stimulation on Self-selected Walking Speed in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07308418) — Improve walking speed with vibrotactile
- [IMPACT 360 Study for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07443293) — Slow Parkinson progression through lifestyle
- [Basal Ganglia Contributions to Transitions in Freezing of Gait and Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06848205) — Reduce freezing episodes while walking
- [The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients: A Randomized Controlled Study](https://parkinsonspathways.com/trial/NCT07442370) — Improve mobility with rotational exercises
- [Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach](https://parkinsonspathways.com/trial/NCT07316296) — Atomoxetine reduces freezing of gait
- [A Prospective Observational Study for the Predictors of Clinical Outcomes of Deep Brain Stimulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07376278) — Predict benefit from brain stimulation
- [Somato-cognitive Action Network Targeted Epidural Modulation for Parkinson's Disease (STEM-PD): a Prospective Open-label Clinical Trial](https://parkinsonspathways.com/trial/NCT06919822) — Stabilize movement reduce off periods
- [Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders](https://parkinsonspathways.com/trial/NCT07417280) — Reduce tremor with focused ultrasound
- [Evaluation of the Safety of Electrical Spinal Cord Stimulation in Parkinson's Patients Presenting With Painful Camptocormia](https://parkinsonspathways.com/trial/NCT06291051) — Reduce camptocormia pain with stimulation
- [Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05854524) — Aerobic exercise slows Parkinson progression
- [A Prospective, Non-Interventional Study on the Long-term Effectiveness of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIGON®) in Patients With Parkinson's Disease Previously Treated With Subcutaneous Foslevodopa in Routine Care](https://parkinsonspathways.com/trial/NCT07313176) — Intestinal pump reduces involuntary movements
- [Analysis of Clinical Data and Diagnosis in Any Person Requiring an Assay of Alzheimer Biomarkers in Cerebrospinal Fluid](https://parkinsonspathways.com/trial/NCT04844060) — Use spinal fluid to diagnose
- [Neural Mechanisms and Clinical Applications of Deep Brain Stimulation for Modulating Sleep Dysregulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06914466) — Brain stimulation reduces sleep fragmentation
- [Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease](https://parkinsonspathways.com/trial/NCT04396873) — Image brain cyclooxygenase related inflammation
- [Characterizing Dance-related Physical Activity Behaviors Among Adults Living With Parkinson's Disease for Automated Analyses of Energy Expenditure](https://parkinsonspathways.com/trial/NCT06425731) — Measure dance exercise energy expenditure
- [Multidimensional Evaluation of the Effectiveness of Telerehabilitation-Based Dual-Task Training in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT06416722) — Improve walking while dual tasking
- [Assistive Robotic in the Elderly: Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological Innovation](https://parkinsonspathways.com/trial/NCT04087031) — Improve walking with robotic treadmill
- [Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06772220) — Vitamins lower blood homocysteine levels
- [Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2](https://parkinsonspathways.com/trial/NCT05557864) — Reduce tremor stiffness and slowness
- [Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in Parkinson's Disease R01 HD100670](https://parkinsonspathways.com/trial/NCT04796506) — Improve cognition via resistance training
- [The Impact of a Digital System on the Monitoring and Self-management of Non-motor Symptoms in People With Parkinson's](https://parkinsonspathways.com/trial/NCT07038486) — Improve selfmanagement for nonmotor symptoms
- [Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study](https://parkinsonspathways.com/trial/NCT03233646) — Eye imaging detects Parkinson changes
- [Novel Method for Diagnosis of Neurodegenerative Diseases Based on Saliva Biochemical Profiling](https://parkinsonspathways.com/trial/NCT06869135) — Differentiate neurodegenerative diseases using saliva
- [Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment](https://parkinsonspathways.com/trial/NCT04715984) — Improve cognition through caudate stimulation
- [Real-life, Observational Study on Opicapone in Patients With Parkinson's Disease and Early Motor Fluctuations in Italy](https://parkinsonspathways.com/trial/NCT07403799) — Reduce wearing off motor fluctuations
- [The Effects of Specific Transcranial Direct Current Stimulation tDCS on Cognition in Mild Cognitive Impairment: A Novel Study Protocol](https://parkinsonspathways.com/trial/NCT05919485) — Improve thinking with brain stimulation
- [Influence of Autonomy on Motor Learning in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05960331) — Improve upper limb motor learning
- [Safety and Efficacy of Botulinum Toxin A for Treatment of Overactive Bladder in Parkinson's Disease:Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT05997043) — Botulinum toxin reduces bladder overactivity
- [Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05808504) — Improve thinking with scalp stimulation
- [Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?](https://parkinsonspathways.com/trial/NCT06324422) — Reduce Parkinson fatigue through exercise
- [Validating a Digital Mobility Assessment in Parkinson's Disease Using Wearable Technology - the Mobilise-D Extension Study.](https://parkinsonspathways.com/trial/NCT05874739) — Validate wearable assessment of walking
- [Development of Digital Diagnostics and Intervention Services for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06733077) — Reduce gait freezing with cueing
- [A Study on the Safety, Tolerability, and Efficacy of PDR-001 Injection for Bilateral Stereotactic Subthalamic Nucleus (STN) Clearance of α-synuclein](https://parkinsonspathways.com/trial/NCT07157345) — Brain injection clears sticky protein
- [Balance Tele-rehabilitation With Wearable Technology for Older Adults With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05680597) — Improve balance using wearable technology
- [SL-APO in the Treatment of Patients With Parkinson's Disease: a Real-world Evidence Study to Identify Titration and Usage Schemes - SL-START](https://parkinsonspathways.com/trial/NCT07145190) — Map rescue medication dosing patterns
- [Medico-economic Evaluation Rehabilitation by Serious Games at Home for the Management of Patients With Parkinson's Disease Suffering From Gait and Balance Disorders](https://parkinsonspathways.com/trial/NCT04720365) — Improve gait and balance remotely
- [Detection of Phosphorylated Alpha-synuclein Through Routine Colonoscopy to Diagnose Parkinson's Disease and Related Disorders](https://parkinsonspathways.com/trial/NCT07204652) — Diagnose Parkinsons disease with colonoscopy
- [Research on the Brain Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Regulating PD Motor Symptoms](https://parkinsonspathways.com/trial/NCT06409338) — Gentle ear stimulation improves movement
- [Motor and Cognitive Effects of Table Tennis on Parkinson's Disease: Pilot Controlled Trial](https://parkinsonspathways.com/trial/NCT06444685) — Improve walking balance and attention
- [Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease](https://parkinsonspathways.com/trial/NCT03019757) — Differentiate dementias using brain imaging
- [Canadian Parkinson's Microbiome Initiative: A Pilot Phase 2 Feasibility Randomized Controlled Trial of the MIND Diet in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06207136) — Mediterranean diet slows Parkinson progression
- [Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers in Sleep Dysregulation and Repair](https://parkinsonspathways.com/trial/NCT05070013) — Sensing brain stimulation lengthens sleep
- [Phenotyping of Audition in Patients With Early Stage of Neurodegenerative Disorders (Alzheimer and Parkinson' Diseases)](https://parkinsonspathways.com/trial/NCT07083089) — Characterize hearing changes in Parkinson
- [Steps Against the Burden of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07058285) — Reduce falls with treadmill training
- [Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling](https://parkinsonspathways.com/trial/NCT06529744) — Blood tests predict dementia progression
- [NEuroStimulation for the Treatment of Mild Cognitive Impairment in Parkinson's Disease: an Acceptability Cross-over Study](https://parkinsonspathways.com/trial/NCT06399731) — Improve cognition through brain stimulation
- [REducing SPEECH-related Side-effects of Deep Brain Stimulation in Parkinson's Disease Via Automated Speech Analysis](https://parkinsonspathways.com/trial/NCT05182892) — Improve speech clarity with stimulation
- ["Amazonian Dance for Parkinson": a Protocol Study for a Randomized Clinical Trial on Motor and Non-motor Symptoms of People With Parkinson's.](https://parkinsonspathways.com/trial/NCT06967493) — Improve walking through Amazonian dance
- [Safety and Efficacy of Autologous Induced Neural Stem Cell-derived Dopaminergic Precursor Cells in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05901818) — Restore dopamine to improve walking
- [Exploring the Recovery Function of Sleep in Neurodegeneration - an Observational Cross-Sectional Study](https://parkinsonspathways.com/trial/NCT05402488) — Boost sleep recovery with tones
- [Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06588920) — Improve walking through cognitive rehabilitation
- [A Single-arm, Open-label, Single-dose Clinical Study to Evaluate the Safety and Tolerability of BBM-P002 for Stereotactic Bilateral Putamen Injection in the Treatment of Idiopathic Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07195825) — Brain injection reduces movement problems
- [Prospective Study of Constant Current Versus Constant Voltage Deep Brain Stimulation in Patients with Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06742450) — Steadier brain pulses reduce tremor
- [Effects of Transcranial Direct Current Stimulation Over the Supplementary Motor Area Combined With Nordic Walking on Gait and Balance in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07381907) — Improve walking speed and balance
- [A Composition Comprising Glucoraphanin, Myrosinase and a Buffered Solution for Use in the Treatment of Neurodegenerative Diseases](https://parkinsonspathways.com/trial/NCT07360977) — Slow Parkinson progression with glucoraphanin
- [Multi-Stakeholder Engagement for Interdisciplinary Telehealth in Lewy Body Dementia](https://parkinsonspathways.com/trial/NCT05014971) — Improve access to specialist care
- [Artificial Intelligence on Molecular Imaging to Predict the Risks of Parkinson's Disease for Patients With Rapid Eye Movement Sleep Behavior Disorder](https://parkinsonspathways.com/trial/NCT06629207) — Predict Parkinson or dementia risk
- [A Randomized Controlled Trial of Bilateral Subthalamic Stimulation in Patients With Parkinson's Disease and Impulse Control Disorders](https://parkinsonspathways.com/trial/NCT06498349) — Reduce impulse control disorder behaviors
- [Phase 1 Study to Evaluate [18F]ACI-15916 as a Potential PET Radioligand for Imaging α-synuclein Deposits in the Brain of Patients With Suspected α-synuclein Pathology Compared With Healthy Volunteers](https://parkinsonspathways.com/trial/NCT06891703) — Detect brain alpha synuclein deposits
- [Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06899022) — Improve attention during brain stimulation
- [10,000 STEP CLUB: Community Walking Program to Decrease Sedentary Behavior, Fear of Falling Avoidance Behavior, Loneliness, and Social Isolation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06605183) — Increase daily steps and socialization
- [Pairing Subjective Patient Rating and Local Field Potentials for DBS Programming](https://parkinsonspathways.com/trial/NCT07336199) — Personalize brain stimulation to symptoms
- [Impact of a Biophoton Therapy on Patients With Brain Disorders](https://parkinsonspathways.com/trial/NCT06147999) — Test biophoton therapy for tremor
- [Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06518824) — Improve thinking through implanted stimulation
- [BOOST-PD - Better On-time Observations of Motor Fluctuations Using Wearable Sensor Technology: A Naturalistic Study on IPX-203 for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07138560) — Increase daily steady on time
- [Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease](https://parkinsonspathways.com/trial/NCT05400499) — Improve vision guided reaching ability
- [Effects of Motor Imagery Training on Kinesiophobia, Gait, and Balance in Parkinson's Disease Patients](https://parkinsonspathways.com/trial/NCT07193355) — Improve walking confidence through imagery
- [Phase I Randomized, Double-blind Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Nucleus Basalis of Meynert or Substantia Nigra for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery](https://parkinsonspathways.com/trial/NCT06683378) — Protect substantia nigra dopamine neurons
- [Evaluation Study of the Effects and Safety of Whole-Body Photobiomodulation Therapy on Motor and Cognitive Changes in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07271927) — Improve motor and cognitive function
- [Exploring the Possible Beneficial Impact of Non-invasive and Invasive Neuromodulation on Freezing of Gait in Parkinson's Disease During Different Ambulatory Complexities: An Electrophysiological and fMRI Study](https://parkinsonspathways.com/trial/NCT06505460) — Reduce freezing through brain stimulation
- [The Effect of Visual Feedback From the SpiroGym Mobile Application on Expiratory Muscle Strength Training Performance in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06942533) — Increase expiratory strength with SpiroGym
- [The Immediate Effect of Mental Imagery on Upper Extremity Skills With the Patients of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07193303) — Improve hand dexterity with imagery
- [Study of the Progression of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Patients With Parkinson's Disease Divided Into Brain-first and Body-first Phenotypes](https://parkinsonspathways.com/trial/NCT07187843) — Track axial and cognitive progression
- [Aim 3 Particle Swarm Optimization Postural Instability Gait Disorder](https://parkinsonspathways.com/trial/NCT05934747) — Optimize brain stimulation improving walking
- [The Chinese DENOVO Parkinson's Disease Registry](https://parkinsonspathways.com/trial/NCT05767151) — Track early Parkinson disease progression
- [Deep Cognitive Endophenotyping of Parkinson's Disease: A Platform Development and Pilot Study](https://parkinsonspathways.com/trial/NCT05025254) — Detect early cognitive decline Parkinsons
- [Frequency-dependent Modulation of Inhibitory Control Via Subthalamic Nucleus Subregional Stimulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07022522) — Improve ability to stop actions
- [The Novel Application of fNIRS-based Neurofeedback to Enhance Effects of Motor Imagery on Balance and Gait Performance in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05800470) — Improve walking balance with neurofeedback
- [Double-blind Randomised-controlled Within-subject Crossover Trial to Determine Levetiracetam Efficacy for Memory Impairment in Parkinson's Disease: A Proof-of-concept Study](https://parkinsonspathways.com/trial/NCT04643327) — Reduce memory impairment using levetiracetam
- [Analysis of the Relationship Between Immunosuppressive Treatment Status and Clinical Course of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06834191) — Determine whether immunosuppression slows progression
- [Gait Pattern Analysis in Neurological Disease](https://parkinsonspathways.com/trial/NCT02994719) — Improve walking with Parkinson medication
- [Edmond J Safra, Accelerating Clinical Trials in Parkinson's Disease (EJS ACT-PD) - a Multi-arm Multi-stage Platform Trial for Potential Disease Modifying Approaches.](https://parkinsonspathways.com/trial/NCT07207057) — Slow Parkinson progression with telmisartan
- [Utilization of Robotic EksoSkeleton to Achieve High Dosing, Intensity, and Complexity of Gait in Treatment of People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06225830) — Improve walking via robotic exoskeleton
- [Predictors and Mechanisms of Tremor Relapse After MR-Guided Focused Ultrasound Thalamotomy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07284719) — Prevent tremor relapse after thalamotomy
- [Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst](https://parkinsonspathways.com/trial/NCT05658302) — Targeted brain stimulation reduces tremor
- [Mechanisms and Effects of Pallidal Deep Brain Stimulation on Levodopa Resistant Motor Signs in Parkinson's Disease; Udall Project 2 Aim 2A&C](https://parkinsonspathways.com/trial/NCT05656586) — Brain stimulation reduces persistent stiffness
- [Understand Me for Life: Using Noise-augmented Automatic Speech Recognition to Improve Intelligibility in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06540989) — Improve speech clarity with feedback
- [A Phase 2, Randomized, Double-blind, Sham Surgery-controlled Study of the Efficacy and Safety of Intraputaminal AAV2-GDNF in the Treatment of Adults With Moderate Stage Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06285643) — Gene therapy reduces movement fluctuations
- [A Phase I, Open Label, Single Arm, Dose Escalation and Dose Expansion Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of Human Induced Pluripotent Stem Cell Derived Dopaminergic Progenitor Cells (NCR201) Injection in the Treatment of Subjects With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06978920) — Donor cell injections reduce tremor
- [Evaluation of the Cognitive Stimulation Treatment in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06323278) — Improve cognitive function with training
- [Empower Your Mind to Embrace Your Life: Development and Efficacy Study of a Videoconference-delivered Group Intervention Based on Acceptance and Commitment Therapy for People With Young-onset Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07310147) — Reduce anxiety and improve functioning
- [Clinical Efficacy and Mechanism of tDCS for Dysphagia in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07153692) — Improve swallowing safety and function
- [Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments](https://parkinsonspathways.com/trial/NCT07154511) — Improve cognitive function with tributyrin
- [Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05482126) — Improve movement via sensory filtering
- [Rehabilitation of Airway Protection in Parkinson's Disease: Comparing In-person and Telehealth Service Delivery Models](https://parkinsonspathways.com/trial/NCT05700825) — Strengthen cough to reduce aspiration
- [The Effect of Exercise Intervention on Posture, Trunk Flexibility and Spine Function in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06536478) — Improve posture and trunk flexibility
- [Interdisciplinary and Intersectoral Telemedicine Evaluation, Coordination and Treatment in the Rhine Main+ Parkinson's Network](https://parkinsonspathways.com/trial/NCT06479083) — Improve Parkinson care via telemedicine
- [D-SPARK: A Randomized Double Blind Clinical Trial of D-Serine for Modifying Parkinson's Disease Progression](https://parkinsonspathways.com/trial/NCT07312110) — Slow Parkinson degeneration using Dserine
- [Understanding Motivation in Parkinson's Patients Through Neurophysiology](https://parkinsonspathways.com/trial/NCT05065151) — Brain stimulation improves daily motivation
- [Feasibility, Acceptability, and Effectiveness of an Online Decision Aid for Patients With Parkinson's Disease Considering Deep Brain Stimulation Surgery Using a Pragmatic, Randomized Pilot Trial](https://parkinsonspathways.com/trial/NCT06446505) — Help decide about brain stimulation
- [Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease](https://parkinsonspathways.com/trial/NCT06580977) — Enhance Parkinsons cognition via exercise
- [Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease - The DREAMS-PD Study](https://parkinsonspathways.com/trial/NCT07110376) — Improve sleep using brain pulses
- [Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease](https://parkinsonspathways.com/trial/NCT06846658) — Find early tests for Parkinson
- [Etude Des Facteurs Prédictifs De L'apparition Et De L'évolution De La Maladie De Parkinson](https://parkinsonspathways.com/trial/NCT02305147) — Identify markers predicting Parkinson progression
- [StepuP: Steps Against the Burden of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07057219) — Improve walking speed through exercise
- [The Effect of an Auditory Rhythmic Cue on the Frequency of Rolling in Patients with Dysphagia and Parkinson's Disease: a Pilot Study](https://parkinsonspathways.com/trial/NCT06695455) — Reduce swallowing roll using rhythm
- [Effects of an External and Combined Focus of Attention-Instructed Exercise Program on Postural Stability and Dual-Task Walking in Parkinson's Disease: A Randomized, Assessor-Blinded, Controlled Trial](https://parkinsonspathways.com/trial/NCT06615115) — Improve balance during dual tasking
- [Comparing Pain Intensity and Discomfort in Patients With Parkinson´s Disease and Healthy Controls During Inducement of Mechanical, Thermal, and Chemical Experimental Pain](https://parkinsonspathways.com/trial/NCT05981261) — Assess experimental pain in Parkinsons
- [24-months, Open-label, Single-Site Extension Study to Evaluate Safety, Tolerability and Efficacy of the Home-based Peroneal Electrical Transcutaneous NeuroModulation (Peroneal eTNM®) Treatment Via Nerve Stimulator URIS ITM in Treatment of Symptoms Related to Movement Disorders in Subjects With Parkinson's Disease (PD) and Essential Tremor (ET)](https://parkinsonspathways.com/trial/NCT06570421) — Reduce freezing episodes while walking
- [Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers](https://parkinsonspathways.com/trial/NCT07392411) — Detect Parkinson and track severity
- [Effect of a 3-week Program of Cane Training and Use on Gait of Individuals With Parkinson's Disease: Protocol for a Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT06950255) — Improve gait stability using cane
- [Development of Digital Diagnostic Devices for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06663826) — Detect freezing through oculomotor markers
- [Feasibility and Preliminary Effects of the Walking Tall App for Home-Based Gait Training in Parkinson's Disease: A Pilot Study](https://parkinsonspathways.com/trial/NCT07380737) — Improve gait through smartphone training
- [Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity](https://parkinsonspathways.com/trial/NCT07324330) — Reduce cognitive decline through exercise
- [The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06455293) — Reduce depressive symptoms in Parkinsons
- [Driving Simulator and People With Neurocognitive Disorders](https://parkinsonspathways.com/trial/NCT06320639) — Driving simulator improves driving safety
- [Longitudinal Measurement of Synaptic Loss and Cognitive Decline in the Long-term Course of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06875765) — Correlate synaptic loss with cognition
- [Pathophysiology of Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF)](https://parkinsonspathways.com/trial/NCT06008704) — Identify serotonin abnormalities causing pain
- [A Double-blinded, Randomized, Parallel-group, Superiority Study to Explore the Neuroprotective Effects of Long-term Transcutaneous Auricular Vagus Nerve Stimulation(taVNS) in Early Parkinson's Disease(PD) Patients](https://parkinsonspathways.com/trial/NCT06665113) — Ear stimulation slows Parkinson progression
- [Rehabilitation of Locomotor Function in Parkinson's Disease by Non-invasive Spinal Cord Stimulation](https://parkinsonspathways.com/trial/NCT06804642) — Improve walking with spinal stimulation
- [Exercise for Cognitive Excellence in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05720468) — Improve cognition through supervised exercise
- [SegwayPD: The Effect of Sensory-augmented Postural Training Using Segway on Motor and Cognitive Function in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05982730) — Improve balance using Segway training
- [Social Perception and Dopaminergic Modulation in Patients With Parkinson's Disease: a Functional MRI Study (Park Social-E-Motion)](https://parkinsonspathways.com/trial/NCT06884722) — Improve recognizing emotions on medication
- [Genetics in Parkinson's Disease: Behavioral and Cognitive Outcomes in Patients Undergoing Dopaminergic Treatment](https://parkinsonspathways.com/trial/NCT06329739) — Genes affect medication side effects
- [A Phase I Clinical Study on the Safety and Tolerability of iPSC-Derived Dopaminergic Neural Progenitor Cell Injection Via Stereotaxic Brain Transplantation for the Treatment of Primary Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07080775) — Cell transplant reduces off time
- [Investigation of the Validity and Reliability of the 6-Minute Pegboard and Ring Test in Parkinson's Patients for Upper Extremity Endurance Assessments](https://parkinsonspathways.com/trial/NCT06482502) — Assess arm endurance measurement reliability
- [Neural Mechanism of Skill Transfer in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07351032) — Improve everyday walking after training
- [Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06405334) — Predict falls by mapping movements
- [Determination of the Minimal Detectable Change and Minimum Clinically Important Change Score of the Parkinson's Disease Questionnaire-8](https://parkinsonspathways.com/trial/NCT06487364) — Rehabilitation measures meaningful daily improvements
- [Efficacy and Safety of Tenofovir Disoproxil Fumarate in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06356662) — Tenofovir slows Parkinson disease progression
- [A Novel Robotic System for Motor-cognitive Exercise for Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06730074) — Improve seated motor cognitive function
- [Parkinson's Disease and Movement Disorders Clinical Database](https://parkinsonspathways.com/trial/NCT04997642) — Measure cognitive decline in Parkinsons
- [The Effects of 24 Weeks Community-based Brisk Walking on Physical Function, Comorbidities, Cognition, Disease Severity, and Health-related Quality of Life in People With Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06707402) — Increase walking speed and endurance
- [Molecular Imaging of LPS-induced Microglial Activation in Parkinson's Disease (PD). A TSPO PET-MR Imaging Study](https://parkinsonspathways.com/trial/NCT05205291) — Map Parkinson brain immune activity
- [Long-Term Behavioral and Cognitive Outcomes of Deep Brain Stimulation in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06329726) — Brain stimulation effects on thinking
- [Step Up to PD: A Community-based Walking Program for People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06859528) — Increase walking distance and endurance
- [Effectiveness of a High-intensity Functional Training (HIFT) Program on Functional and Cognitive Performance in People with Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06879821) — Improve everyday movement and thinking
- [Affordances and Impairments: A Paradigm for Understanding Obstacle Crossing in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06932679) — Improve obstacle crossing while walking
- [Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands](https://parkinsonspathways.com/trial/NCT06193252) — Slow Parkinson progression through exercise
- [Contribution of the Kinematic Theory in the Early Differential Diagnosis of the Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06161636) — Use kinematics to diagnose Parkinson
- [Identifying the Neural Basis of Depression in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06402955) — Treat Parkinsons depression with ketamine
- [A Pragmatic Randomized Trial Comparing Antipsychotics in Lewy Body Disease](https://parkinsonspathways.com/trial/NCT05590637) — Compare pimavanserin and quetiapine effectiveness
- [Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment](https://parkinsonspathways.com/trial/NCT06688968) — Measure emotional response to music
- [Prospective Head-to-head Comparison of Cardiac [18F]-MFBG PET Versus [123I]-MIBG SPECT in the Differentiation Between Parkinson's Disease and Multiple System Atrophy and Between Dementia With Lewy Bodies and Alzheimer's Disease](https://parkinsonspathways.com/trial/NCT06120049) — Accurately diagnose Lewy body dementia
- [NYSCF Scientific Discovery Biobank](https://parkinsonspathways.com/trial/NCT06203106) — Enable new Parkinson treatment development
- [Sleep-specific DBS Therapy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05962489) — Improve sleep in Parkinson patients
- [Clinical Study on the Efficacy and Safety of rTMS Regulating Slow-wave Sleep to Delay the Progression of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06002581) — Magnetic stimulation slows Parkinson progression
- [Neurostimulation of the Nucleus Basalis of Meynert for the Cognitive-Motor Syndrome in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05968703) — Improve attention memory and walking
- [STEPWISE Parkinson: A Smartphone Based, Titrated Exercise Solution for Patients With Parkinson's Disease in Daily Life](https://parkinsonspathways.com/trial/NCT04848077) — Increase daily walking step count
- [Research on Novel Biomarkers for Early Diagnosis of Parkinson's Disease:An Observational, Multicenter, Non-Randomized Controlled Study](https://parkinsonspathways.com/trial/NCT06232772) — Alpha synuclein detects early Parkinson
- [Using Biofeedback During Exergaming to Attenuate Alpha Oscillations to Improve Postural Control in People Living With Parkinson's.](https://parkinsonspathways.com/trial/NCT05986643) — Improve balance using neurofeedback exergaming
- [Precision Neuroimaging of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07024875) — Predict Parkinson progression using neuroimaging
- [The Benefits of Hippotherapy for Patients With Parkinson's Disease of 75 Years of Age or More at Risk of Losing Their Independance.](https://parkinsonspathways.com/trial/NCT06500182) — Hippotherapy improves balance and mobility
- [Steps Against the Burden of Parkinson's Disease - TelAviv/Bologna](https://parkinsonspathways.com/trial/NCT07105787) — Improve walking speed and stability
- [Transcranial Direct Current Stimulation (tDCS) to Improve Motor Function and Motor Fatigue in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT06883266) — Reduce movement slowness and fatigue
- [Transcranial Magnetic Stimulation (TMS) Related Measures as Biomarker of Cognitive Impairment in Parkinson's Disease (PD)](https://parkinsonspathways.com/trial/NCT06835595) — Magnetic pulses detect thinking problems
- [Deep Brain Stimulation Therapy in Movement Disorders](https://parkinsonspathways.com/trial/NCT02119611) — Brain stimulation reduces disabling tremor
- [Role of Physical Activity on Neuroinflammation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06977204) — Lower brain inflammation using exercise

…and 77 more. See the full list at [https://parkinsonspathways.com/trials/symptom/cognition](https://parkinsonspathways.com/trials/symptom/cognition).

## Related topics

- [Psychosis & Hallucinations](https://parkinsonspathways.com/trials/symptom/psychosis)
- [Ambroxol](https://parkinsonspathways.com/trials/drug/ambroxol)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
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