---
title: "Clinical Trials for Parkinson's Depression and Anxiety | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials studying depression, anxiety, and mood. See enrolling studies and get an email when a new trial opens."
canonical_url: "https://parkinsonspathways.com/trials/symptom/depression-anxiety"
topic_type: symptom
source: "Parkinson's Pathways"
---
# Clinical Trials for Parkinson's Depression and Anxiety

Depression and anxiety are among the most common non-motor symptoms of Parkinson's, and they are not just a reaction to the diagnosis. The same brain changes that affect movement also affect mood, which is why these symptoms are an active area of research.

Trials in this area test medications, talk therapy and behavioral programs, exercise, and brain-stimulation approaches aimed at improving mood, along with studies that track how depression and anxiety change over time.

Below are the recruiting trials we track that focus on depression and anxiety. Sign up to be emailed when a new one opens.

## 76 recruiting trials

- [The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07610369), Studying medication for Parkinsons depression
- ["Associations of Self-Compassion and Self-Efficacy With Symptom Severity, Functional Status, and Quality of Life in Individuals With Parkinson's Disease: A Cross-Sectional Study"](https://parkinsonspathways.com/trial/NCT07488351), Testing new Parkinson treatment approach
- [Validity and Reliability of the Turkish Version of the Cognitive Self-Efficacy Questionnaire in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07488377), Assess confidence in thinking skills
- [Investigation of the Relationship Between Motor Imagery, Body Awareness, Kinesiophobia, Physical Activity, Symptom Severity, and Physical Frailty in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07488364), Link imagining movements to frailty
- [Exploration of the Reward System in Parkinson's Patients With Paradoxical Sleep Behavior Disorders: a Multimodal Imaging Study](https://parkinsonspathways.com/trial/NCT07213219), Predict impulse control from scans
- [Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06857851), Improve eye alignment and refocusing
- [Effects of Tai Chi Therapy Versus Qi-Gong on Postural Control, Functional Balance , and Motor Function in Stage-I Parkinson's Patients.](https://parkinsonspathways.com/trial/NCT07662837), Comparing Tai Chi Qigong balance
- [PARKINSON BRASIL - Database on Motor and Non-Motor Aspects of Parkinson's Disease in Brazil](https://parkinsonspathways.com/trial/NCT06536348), Map movement mood and sleep
- [Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07478146), Does aerobic training improve walking
- [Effects of the Combination of Physical Exercise and Transcranial Direct Current Stimulation on Motor Function and Underlying Neurophysiological Mechanisms in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07524400), Improve movement with brain stimulation
- [The Effect of MRI-Guided Transcranial Direct Current Stimulation on Cognitive and Affective Symptoms in Persons With Parkinson's Disease and Controls](https://parkinsonspathways.com/trial/NCT06467695), Studying guided stimulation for depression
- [Ultra-High Resolution PET of the Human Brain and Spinal Cord in Healthy Aging, Dementia, Movement Disorders, ALS and Psychotic Disorders](https://parkinsonspathways.com/trial/NCT07509125), Distinguish Parkinson from related disorders
- [Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05568498), Treat Parkinson depression with probiotics
- [The Role of a Personalized Music Intervention Towards Alleviating Apathy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05505019), Reduce apathy through personalized music
- [Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07151378), Reduce overactive dopamine related behaviors
- [Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach](https://parkinsonspathways.com/trial/NCT07316296), Reduce freezing of gait episodes
- [Evaluating the Effect of Mirtazapine on Anxiety in Parkinson's Disease Patients; a Randomized Double-blinded Placebo-controlled Clinical Trial](https://parkinsonspathways.com/trial/NCT06530290), Reduce anxiety symptoms with mirtazapine
- [The Impact of a Digital System on the Monitoring and Self-management of Non-motor Symptoms in People With Parkinson's](https://parkinsonspathways.com/trial/NCT07038486), Improve selfmanagement for nonmotor symptoms
- [Social Behaviors and Quality of Life in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06385184), Improve social engagement and mood
- [Esketamine in Microelectrode Recording-guided Subthalamic Deep-Brain Stimulation for Parkinson's Disease（ASPIRE）：A Randomized Controlled, Double-blind Study](https://parkinsonspathways.com/trial/NCT06543563), Preserve brain signals during surgery
- [Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?](https://parkinsonspathways.com/trial/NCT06324422), Reduce Parkinson fatigue through exercise
- [A Study on the Safety, Tolerability, and Efficacy of PDR-001 Injection for Bilateral Stereotactic Subthalamic Nucleus (STN) Clearance of α-synuclein](https://parkinsonspathways.com/trial/NCT07157345), Clear harmful brain protein clumps
- [Steps Against the Burden of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07058285), Reduce falls with treadmill training
- ["Amazonian Dance for Parkinson": a Protocol Study for a Randomized Clinical Trial on Motor and Non-motor Symptoms of People With Parkinson's.](https://parkinsonspathways.com/trial/NCT06967493), Improve walking through Amazonian dance
- [Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms: Identification of Predictive Patterns of Rehabilitation Outcome and Evaluation of the Impact on Quality of Life](https://parkinsonspathways.com/trial/NCT05748028), Reduce pain and autonomic symptoms
- [Empathy and (Self-)Compassion to Improve the Quality of Life of Parkinson's Disease Patients and Caregivers: an Exploratory Study](https://parkinsonspathways.com/trial/NCT07097298), Improve patient mood with compassion
- [A Randomized Controlled Trial of Bilateral Subthalamic Stimulation in Patients With Parkinson's Disease and Impulse Control Disorders](https://parkinsonspathways.com/trial/NCT06498349), Surgical brain stimulation reduces impulsivity
- [Examining Ketamine Effects on Depression, Neuroplasticity, and Inflammation in Veterans With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06231563), Reduce depressive symptoms using ketamine
- [Early Longitudinal Imaging in the Parkinson's Progression Markers Initiative Using [18F] AV-133 (PPMI AV-133 Prodromal Imaging)](https://parkinsonspathways.com/trial/NCT07265596), Identify brain changes before symptoms
- [Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease](https://parkinsonspathways.com/trial/NCT05400499), Brain stimulation improves eye alignment
- [The Chinese Parkinson's Disease With SNCA Variants Registry](https://parkinsonspathways.com/trial/NCT03523052), Describe symptoms and blood tests
- [Exploring the Possible Beneficial Impact of Non-invasive and Invasive Neuromodulation on Freezing of Gait in Parkinson's Disease During Different Ambulatory Complexities: An Electrophysiological and fMRI Study](https://parkinsonspathways.com/trial/NCT06505460), Reduce freezing through brain stimulation
- [Parkinson's Disease Rehabilitation Using Neurofeedback With Functional Electrical Stimulation and Virtual Reality Feedback for Lower Extremities](https://parkinsonspathways.com/trial/NCT06690931), Can brain monitoring improve walking
- [Deep Cognitive Endophenotyping of Parkinson's Disease: A Platform Development and Pilot Study](https://parkinsonspathways.com/trial/NCT05025254), Detect early cognitive decline Parkinsons
- [Double-blind Randomised-controlled Within-subject Crossover Trial to Determine Levetiracetam Efficacy for Memory Impairment in Parkinson's Disease: A Proof-of-concept Study](https://parkinsonspathways.com/trial/NCT04643327), Reduce memory impairment using levetiracetam
- [Observational Case Series of Patients With Parkinson's Disease (PD) Attending a Complementary Medicine Neuro-degenerative Disease (NDD) Clinic.](https://parkinsonspathways.com/trial/NCT07207096), Complementary medicine to reduce stiffness
- [Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease (CHAMPION)：A Randomized Controlled, Non-Inferiority Study](https://parkinsonspathways.com/trial/NCT05550714), Confirm tremor control under anesthesia
- [Empower Your Mind to Embrace Your Life: Development and Efficacy Study of a Videoconference-delivered Group Intervention Based on Acceptance and Commitment Therapy for People With Young-onset Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07310147), Reduce anxiety and improve functioning
- [Understanding Deep Brain Stimulation-induced Mania: Finding Potential Predictors to Optimize Treatment](https://parkinsonspathways.com/trial/NCT05444907), Prevent mania after brain stimulation
- [Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07402928), Map dopamine signals for mood
- [StepuP: Steps Against the Burden of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07057219), Improve walking speed through exercise
- [Comparing Pain Intensity and Discomfort in Patients With Parkinson´s Disease and Healthy Controls During Inducement of Mechanical, Thermal, and Chemical Experimental Pain](https://parkinsonspathways.com/trial/NCT05981261), Assess experimental pain in Parkinsons
- [Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06088355), Improve walking speed with exercise
- [Clinical Study Evaluating the Efficacy and Safety of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05576818), Reduce motor symptoms using synbiotic
- [The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06455293), Reduce depressive symptoms in Parkinsons
- [Neurophysiology of Reward Signaling in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07409207), Improve mood through caudate stimulation
- [Pathophysiology of Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF)](https://parkinsonspathways.com/trial/NCT06008704), Identify serotonin abnormalities causing pain
- [Effects of Self-controlled Practice on Motor Learning and Motivation in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07028515), Improve upper limb motor learning
- [A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis: a Single-center, Randomized, Double-blind Study](https://parkinsonspathways.com/trial/NCT06304285), Can gut acupuncture ease movement
- [Genetics in Parkinson's Disease: Behavioral and Cognitive Outcomes in Patients Undergoing Dopaminergic Treatment](https://parkinsonspathways.com/trial/NCT06329739), Determine if mutation affects thinking
- [Determination of the Minimal Detectable Change and Minimum Clinically Important Change Score of the Parkinson's Disease Questionnaire-8](https://parkinsonspathways.com/trial/NCT06487364), Rehabilitation measures meaningful daily improvements
- [Parkinson's Disease and Movement Disorders Clinical Database](https://parkinsonspathways.com/trial/NCT04997642), Measure cognitive decline in Parkinsons
- [The Effects of 24 Weeks Community-based Brisk Walking on Physical Function, Comorbidities, Cognition, Disease Severity, and Health-related Quality of Life in People With Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06707402), Increase walking speed and endurance
- [Long-Term Behavioral and Cognitive Outcomes of Deep Brain Stimulation in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06329726), How brain stimulation affects thinking
- [The Link Between the Training of Nursing Home Professionals and the Quality of Life of Residents With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06908460), Reduce complications through staff training
- [Identifying the Neural Basis of Depression in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06402955), Treat Parkinsons depression with ketamine
- [A Pilot RCT of a Remote Physical Activity Coaching Intervention to Promote Engagement in Physical Activity for People With Parkinson's Disease in Qatar](https://parkinsonspathways.com/trial/NCT06962930), Boost Parkinson patients physical activity
- [Steps Against the Burden of Parkinson's Disease - TelAviv/Bologna](https://parkinsonspathways.com/trial/NCT07105787), Improve walking speed and stability
- [Role of Physical Activity on Neuroinflammation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06977204), Lower brain inflammation using exercise
- [SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05765110), Speech tracks movement mood thinking
- [Subthalamic and Cortical Electrophysiological Correlates of Motor and Neuropsychiatric Fluctuations in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07404241), Identify signals predicting mood fluctuations
- [Spinal Cord Stimulation for Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06798844), Testing spinal stimulation for freezing
- [Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04650932), Brain stimulation reduces thinking problems
- [International Validation of Two Non-motor Scales in Parkinson's Disease: the Neuropsychiatric Fluctuations Scale (NFS) and the Shame in Parkinson's Disease (SPARK) Scale](https://parkinsonspathways.com/trial/NCT04366804), Validate scales measuring mood fluctuations
- [AV133 Longitudinal Imaging Study in Patients With Early and Prodromal Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06456684), Track brain protein loss annually
- [Efficacy and Safety of Entacapone Combined With Madopar in the Treatment of Early Parkinson's Disease: An Observational, Multicenter, Case-Control Study](https://parkinsonspathways.com/trial/NCT06928519), Reduce medication wearing off fluctuations
- [Enhancing Psychological Wellbeing and the Patient-caregiver Relationship Through Dyadic Mindfulness: A Randomized Controlled Trial in People With Parkinson's Disease and Their Caregivers](https://parkinsonspathways.com/trial/NCT06821230), Reduce depression anxiety and stress
- [The Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation on Impulse Control Disorders in Parkinson's Disease Patients on Dopamine Replacement Therapy.](https://parkinsonspathways.com/trial/NCT06237868), Studying magnetic stimulation for impulsivity
- [The Effects of Different Exercise Modalities on Sleep Quality and Architecture in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05644327), Improve sleep quality through exercise
- [Evaluation of the Effects of Aquatic Therapy on Activities of Daily Living, Walking, Balance, Posture, Pain, and Depression in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT07390825), Improve walking balance via aquatherapy
- [Comparing the Effectiveness of Online Self-management Program and On-site Task-related Training for People With Early Stage Parkinson's Disease on Activity Participation and Quality of Life](https://parkinsonspathways.com/trial/NCT06248073), Increase participation in daily activities
- [Stimulation of the External Pallidal Segment for Insomnia in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04116996), Improve insomnia with pallidal stimulation
- [Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders](https://parkinsonspathways.com/trial/NCT04061135), Can brain recordings explain movement
- [Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD](https://parkinsonspathways.com/trial/NCT06169852), Optimize brain stimulation for movement
- [Short- and Long-term Behavioral, Cognitive and Motor Outcomes of Frameless Deep Brain Stimulation in Patients With Parkinson's Disease: a Prospective Observational Study](https://parkinsonspathways.com/trial/NCT05752656), Reduce tremor using brain stimulation
- [Machine Learning Analysis Of The Tapping Test And The Archimedean Spiral For The Differential Diagnosis Of Essential Tremor And Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06378619), Distinguish Parkinson from essential tremor

## Related topics

- [Sleep Problems](https://parkinsonspathways.com/trials/symptom/sleep)
- [Cognition & Memory](https://parkinsonspathways.com/trials/symptom/cognition)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)