---
title: "Clinical Trials for Parkinson's Dyskinesia | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials studying levodopa-induced dyskinesia. See enrolling studies and get an email when a new dyskinesia trial opens."
canonical_url: "https://parkinsonspathways.com/trials/symptom/dyskinesia"
topic_type: symptom
source: "Parkinson's Pathways"
---
# Clinical Trials for Parkinson's Dyskinesia

Dyskinesia is the involuntary, dance-like movement that often shows up after years of levodopa treatment. It is one of the most disruptive long-term side effects of standard Parkinson's care, and a meaningful share of current research is focused on managing or preventing it.

Trials in this area study new medications designed to reduce dyskinesia, smarter levodopa formulations meant to keep blood levels steadier, and devices that deliver medication more consistently.

Below are the recruiting trials we track that focus on dyskinesia. Sign up to be emailed when a new one opens.

## 33 recruiting trials

- [Effects of Trunk Control Exercises and Mirror Therapy on Balance and Posture in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07610031) — Improve trunk posture and balance
- [Evaluation of the Safety and Feasibility of a Single Transplantation of 10 Million Human Embryonic Stem Cell-Derived Dopaminergic Progenitor Cells Into the Bilateral Striatum of Patients With Moderately Severe Parkinson's Disease: a Multicenter, Open-label, Single-arm Phase I Clinical Trial](https://parkinsonspathways.com/trial/NCT07572071) — Improve walking and reduce stiffness
- [Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.](https://parkinsonspathways.com/trial/NCT07398157) — Personalize brain stimulation for movement
- [Transcranial Direct Current Stimulation Treatment of Cognitive Dysfunction in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT03025334) — Brain stimulation improves thinking skills
- [Phase 2, Double-blind, Placebo-controlled Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations](https://parkinsonspathways.com/trial/NCT07432958) — Reduce wearing off between doses
- [The Effect of Motor Imagery Added to Conventional Rehabilitation on Balance and Kinesiophobia in Patients With Parkinson's Disease: A Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07495462) — Improve balance through mental rehearsal
- [Safety, Tolerability and Symptomatic Efficacy of the ROCK-Inhibitor Fasudil in Patients With Parkinson's Disease (ROCK-PD)](https://parkinsonspathways.com/trial/NCT05931575) — Reduce motor symptoms with fasudil
- [A Prospective, Non-Interventional Study on the Long-term Effectiveness of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIGON®) in Patients With Parkinson's Disease Previously Treated With Subcutaneous Foslevodopa in Routine Care](https://parkinsonspathways.com/trial/NCT07313176) — Intestinal pump reduces involuntary movements
- [An Open Multi-centre Investigation to Evaluate the Performance of the Paragit Sleeve With build-in sEMG Sensors, Kinetic Sensors, and Smart-textile to Measure and Monitor Motor Symptoms and Treatment-induced Dyskinesia in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06490861) — Monitor involuntary movements and tremor
- [Research on the Brain Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Regulating PD Motor Symptoms](https://parkinsonspathways.com/trial/NCT06409338) — Gentle ear stimulation improves movement
- [Home Telerehabilitation Based on Serious Games for Continuity of Care in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05773885) — Improve balance using telerehabilitation games
- [Safety and Efficacy of Autologous Induced Neural Stem Cell-derived Dopaminergic Precursor Cells in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05901818) — Restore dopamine to improve walking
- [A Novel Accessible and Widespread Healthcare Service Model Based on Technology Innovation for Objective (Early) Diagnosis and Therapeutic Monitoring of Parkinson's Disease Promoting Continuity of Care](https://parkinsonspathways.com/trial/NCT06907589) — Detect subtle walking changes early
- [BOOST-PD - Better On-time Observations of Motor Fluctuations Using Wearable Sensor Technology: A Naturalistic Study on IPX-203 for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07138560) — Increase daily steady on time
- [Adaptation Of The Parkinson's Disease Dyskinesia Questionnaire Into Turkish And Its Validity And Reliability In Parkinson's Patient](https://parkinsonspathways.com/trial/NCT07023224) — Validate Turkish involuntary movements scale
- [Effects of an External and Combined Focus of Attention-Instructed Exercise Program on Postural Stability and Dual-Task Walking in Parkinson's Disease: A Randomized, Assessor-Blinded, Controlled Trial](https://parkinsonspathways.com/trial/NCT06615115) — Improve balance during dual tasking
- [Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06088355) — Increase walking endurance through exercise
- [Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers](https://parkinsonspathways.com/trial/NCT07392411) — Detect Parkinson and track severity
- [Pathophysiology of Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF)](https://parkinsonspathways.com/trial/NCT06008704) — Identify serotonin abnormalities causing pain
- [Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing](https://parkinsonspathways.com/trial/NCT05818189) — Improve walking with tactile cueing
- [A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications](https://parkinsonspathways.com/trial/NCT05539196) — Reduce medication refractory motor complications
- [Efficacy of Integrating Artificial Intelligence Solutions in Rehabilitation in Postural Trunk Disorders in Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT07010328) — Reduce forward and sideways leaning
- [Observational Study Evaluating Subcutaneous LDp/CDp Solution for Infusion Effectiveness on Sleep Disturbances in Advanced Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07284342) — Steady medication infusion improves sleep
- [Deep Brain Stimulation Therapy in Movement Disorders](https://parkinsonspathways.com/trial/NCT02119611) — Brain stimulation reduces disabling tremor
- [Neuromodulation électrique Continue du Globus Pallidus Dans la Maladie de Parkinson Par l'électrode Directionnelle CARTESIA™](https://parkinsonspathways.com/trial/NCT05626608) — Reduce tremor and involuntary movements
- [Efficacy of Deep Brain Stimulation and Levodopa on Freezing of Gait in Advanced Parkinson's Disease: a Comparative Study](https://parkinsonspathways.com/trial/NCT06316232) — Reduce freezing episodes during walking
- [Safety, Tolerability and Exploratory Efficacy of EC5026 in Parkinson's Disease (STEP Study)](https://parkinsonspathways.com/trial/NCT07142044) — Slow Parkinson brain cell loss
- [Cortical Electrophysiology of Response Inhibition in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06234995) — Improve ability to stop actions
- [Network Based Repetitive Transcranial Magnetic Stimulation (rTMS) as an Intervention for Levodopa-induced Dyskinesia (LID) in Parkinson's Disease (PD)](https://parkinsonspathways.com/trial/NCT06570824) — Magnetic stimulation reduces involuntary jerks
- [Role of the Subthalamic Nucleus in the Control of Movement: Physiopathology of Akinesia in Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT01682668) — Brain stimulation reduces movement fluctuations
- [Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD](https://parkinsonspathways.com/trial/NCT06169852) — Reduce tremor stiffness and slowness
- [Safety and Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Ambulatory Function in Patients With Parkinson Disease](https://parkinsonspathways.com/trial/NCT06350617) — Personalized stimulation to improve walking
- [Machine Learning Analysis Of The Tapping Test And The Archimedean Spiral For The Differential Diagnosis Of Essential Tremor And Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06378619) — Distinguish essential tremor from Parkinsons

## Related topics

- [OFF Time](https://parkinsonspathways.com/trials/symptom/off-time)
- [Tremor](https://parkinsonspathways.com/trials/symptom/tremor)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)