---
title: "Clinical Trials for Freezing of Gait in Parkinson's | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials studying freezing of gait. See enrolling studies and get an email when a new freezing-of-gait trial opens."
canonical_url: "https://parkinsonspathways.com/trials/symptom/freezing-of-gait"
topic_type: symptom
source: "Parkinson's Pathways"
---
# Clinical Trials for Freezing of Gait

Freezing of gait is the sudden, brief feeling that your feet are stuck to the floor, often when starting to walk, turning, or passing through a doorway. It is one of the symptoms that responds least well to standard Parkinson's medications, and it is a major cause of falls.

Trials in this area test cueing devices that prompt stepping, exercise and physical therapy programs, and medications targeting pathways beyond dopamine. Some are observational studies tracking how freezing changes over time.

Below are the recruiting trials we track that focus on freezing of gait. Sign up to be emailed when a new one opens.

## 36 recruiting trials

- [Stimulating the Vagus Nerve to Improve Gait in Veterans With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06562569) — Home neck stimulation improves walking
- [Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07488026) — Reduce freezing episodes while walking
- [Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06416345) — Wearable cues reduce daily freezing
- [FREEZE-Path Cohort: Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)](https://parkinsonspathways.com/trial/NCT07386015) — Predict falls due to freezing
- [Basal Ganglia Contributions to Transitions in Freezing of Gait and Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06848205) — Reduce freezing episodes while walking
- [Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach](https://parkinsonspathways.com/trial/NCT07316296) — Atomoxetine reduces freezing of gait
- [Study on Preliminary Safety and Efficacy of the ARC-IM Therapy to Alleviate Locomotor Deficits in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06295614) — Alleviate gait freezing and instability
- [Development of Digital Diagnostics and Intervention Services for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06733077) — Reduce gait freezing with cueing
- [Medico-economic Evaluation Rehabilitation by Serious Games at Home for the Management of Patients With Parkinson's Disease Suffering From Gait and Balance Disorders](https://parkinsonspathways.com/trial/NCT04720365) — Improve gait and balance remotely
- [A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05292794) — Reduce freezing of gait episodes
- [Exploring the Possible Beneficial Impact of Non-invasive and Invasive Neuromodulation on Freezing of Gait in Parkinson's Disease During Different Ambulatory Complexities: An Electrophysiological and fMRI Study](https://parkinsonspathways.com/trial/NCT06505460) — Reduce freezing through brain stimulation
- [Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06506058) — Reduce freezing episodes while walking
- [Effect of AR Environment Stimulation on Proactive and Reactive Modulation of Gait in Individuals With Parkinson Disease](https://parkinsonspathways.com/trial/NCT06598878) — Reduce freezing episodes while walking
- [Investigating Neural Biomarkers for Gait in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT05820074) — Improve gait using Percept neurostimulation
- [Effects of an External and Combined Focus of Attention-Instructed Exercise Program on Postural Stability and Dual-Task Walking in Parkinson's Disease: A Randomized, Assessor-Blinded, Controlled Trial](https://parkinsonspathways.com/trial/NCT06615115) — Improve balance during dual tasking
- [24-months, Open-label, Single-Site Extension Study to Evaluate Safety, Tolerability and Efficacy of the Home-based Peroneal Electrical Transcutaneous NeuroModulation (Peroneal eTNM®) Treatment Via Nerve Stimulator URIS ITM in Treatment of Symptoms Related to Movement Disorders in Subjects With Parkinson's Disease (PD) and Essential Tremor (ET)](https://parkinsonspathways.com/trial/NCT06570421) — Reduce freezing episodes while walking
- [Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation](https://parkinsonspathways.com/trial/NCT06951906) — Predict brain stimulation easing freezing
- [Development of Digital Diagnostic Devices for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06663826) — Detect freezing through oculomotor markers
- [Study of the Link Between Freezing of Gait and Oropharyngeal Freezing in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT06713265) — Link gait freezing with swallowing
- [A Double-blinded, Randomized, Parallel-group, Superiority Study to Explore the Neuroprotective Effects of Long-term Transcutaneous Auricular Vagus Nerve Stimulation(taVNS) in Early Parkinson's Disease(PD) Patients](https://parkinsonspathways.com/trial/NCT06665113) — Ear stimulation slows Parkinson progression
- [Neural Mechanism of Skill Transfer in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07351032) — Improve everyday walking after training
- [Preventing Freezing of Gait in Parkinson's Disease Using Soft Robotic Apparel](https://parkinsonspathways.com/trial/NCT06602544) — Reduce freezing episodes during walking
- [Affordances and Impairments: A Paradigm for Understanding Obstacle Crossing in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06932679) — Improve obstacle crossing while walking
- [Using Biofeedback During Exergaming to Attenuate Alpha Oscillations to Improve Postural Control in People Living With Parkinson's.](https://parkinsonspathways.com/trial/NCT05986643) — Improve balance using neurofeedback exergaming
- [Accelerated TMS for Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06982638) — Reduce freezing episodes during walking
- [Efficacy of Deep Brain Stimulation and Levodopa on Freezing of Gait in Advanced Parkinson's Disease: a Comparative Study](https://parkinsonspathways.com/trial/NCT06316232) — Reduce freezing episodes during walking
- [Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05298150) — Reduce freezing with dynamic cycling
- [Spinal Cord Stimulation for Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06798844) — Spinal cord stimulation reduces freezing
- [Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06911229) — Reduce freezing episodes during walking
- [Application of Thoracic Epidural Spinal Cord Stimulation (SCS) for Managing Freezing of Gait (FOG) in Patients With Advanced Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06630702) — Reduce freezing episodes during walking
- [Strength-Endurance Circuit Training in Parkinson's Disease: Effects on Disease Severity, Physical Performance, Blood Biomarkers and Quality of Life.](https://parkinsonspathways.com/trial/NCT06893055) — Improve walking endurance and strength
- [Characterization of Subthalamic Nucleus Deep Brain Stimulation Laterality on Visuospatial Attention and Correlation to Freezing of Gait in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06994728) — Determine side that reduces freezing
- [Unravelling the Neural Mechanisms Underlying Compensation Strategies for Gait Impairments in Parkinson's Disease: a Transnational, Multimodal Approach](https://parkinsonspathways.com/trial/NCT06142448) — Improve walking using auditory cueing
- [An International Multimodal Protocol for Assessing Freezing of Gait in Individuals Living with Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06519279) — Characterize freezing of gait episodes
- [Effects of a Remote Mental and Physical Practice Intervention on Freezing of Gait in People With Parkinson's Disease: a Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT06957405) — Reduce freezing of gait remotely
- [Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT06791902) — Reduce freezing and improve walking

## Related topics

- [Balance & Falls](https://parkinsonspathways.com/trials/symptom/balance-falls)
- [OFF Time](https://parkinsonspathways.com/trials/symptom/off-time)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)