Clinical Trials for OFF Time and Motor Fluctuations
OFF time is when Parkinson's medication wears off before the next dose and symptoms return. Over the years the window of good control can narrow, and some people experience unpredictable swings between ON and OFF that are hard to manage with timing alone.
Trials here test new medications, longer-lasting or steadier levodopa formulations, on-demand rescue treatments for sudden OFF episodes, and devices that deliver medication more consistently.
Below are the recruiting trials we track that focus on OFF time and motor fluctuations. Sign up to be emailed when a new one opens.
37 Recruiting OFF Time Trials
- Personalize brain stimulation for movement, NCT07398157, RECRUITING
- Relieve movement symptoms between doses, NCT07400731, RECRUITING
- Reduce off time with infusion, NCT07382440, RECRUITING
- Reduce wearing off between doses, NCT07432958, PHASE2, RECRUITING
- Improve balance through mental rehearsal, NCT07495462, RECRUITING
- Document motor complications despite medication, NCT07330258, RECRUITING
- Cell transplant improves motor symptoms, NCT07102342, PHASE1, PHASE2, RECRUITING
- Shorten daily periods without movement, NCT07422675, PHASE1, RECRUITING
- Stabilize movement reduce off periods, NCT06919822, RECRUITING
- Intestinal pump reduces involuntary movements, NCT07313176, RECRUITING
- Reduce wearing off motor fluctuations, NCT07403799, RECRUITING
- Reduce off time and fluctuations, NCT07219927, RECRUITING
- Cell implant reduces off time, NCT06687837, PHASE1, RECRUITING
- Map rescue medication dosing patterns, NCT07145190, RECRUITING
- Steady infusion reduces off periods, NCT06937034, RECRUITING
- Link hormones with motor fluctuations, NCT06582212, RECRUITING
- Reduce medication wearing off symptoms, NCT06145711, RECRUITING
- Increase daily steady on time, NCT07138560, PHASE4, RECRUITING
- Improve walking and leg function, NCT06690931, RECRUITING
- Gene therapy reduces movement fluctuations, NCT06285643, PHASE2, RECRUITING
- Continuous medication reduces motor fluctuations, NCT06916507, RECRUITING
- Predict brain stimulation easing freezing, NCT06951906, PHASE4, RECRUITING
- Cell transplant reduces off time, NCT07080775, PHASE1, RECRUITING
- Reduce medication refractory motor complications, NCT05539196, RECRUITING
- Reduce predictable wearing off periods, NCT06765668, PHASE4, RECRUITING
- Reduce daily off medication time, NCT06944522, PHASE3, RECRUITING
- Steady medication infusion improves sleep, NCT07284342, RECRUITING
- Reduce off period motor fluctuations, NCT07166757, PHASE1, PHASE2, RECRUITING
- Brain stimulation reduces disabling tremor, NCT02119611, RECRUITING
- Reduce tremor and involuntary movements, NCT05626608, RECRUITING
- Reduce motor and neuropsychiatric fluctuations, NCT07404241, RECRUITING
- Reduce medication wearing off fluctuations, NCT06928519, RECRUITING
- Nasal spray reduces off episodes, NCT07156773, PHASE2, RECRUITING
- Reduce predictable off time episodes, NCT06596876, PHASE3, RECRUITING
- Brain stimulation reduces movement fluctuations, NCT01682668, RECRUITING
- Reduce tremor stiffness and slowness, NCT06169852, RECRUITING
- Continuous infusion reduces wearing off, NCT06965374, RECRUITING