Clinical Trials for OFF Time and Motor Fluctuations
OFF time is when Parkinson's medication wears off before the next dose and symptoms return. Over the years the window of good control can narrow, and some people experience unpredictable swings between ON and OFF that are hard to manage with timing alone.
Trials here test new medications, longer-lasting or steadier levodopa formulations, on-demand rescue treatments for sudden OFF episodes, and devices that deliver medication more consistently.
Below are the recruiting trials we track that focus on OFF time and motor fluctuations. Sign up to be emailed when a new one opens.
25 Recruiting OFF Time Trials
- Reduce under and over stimulation, NCT07682311, RECRUITING
- Personalize brain stimulation for movement, NCT07398157, RECRUITING
- Relieve movement symptoms between doses, NCT07400731, RECRUITING
- Reduce off time with infusion, NCT07382440, RECRUITING
- Reduce wearing off between doses, NCT07432958, PHASE2, RECRUITING
- Document motor complications despite medication, NCT07330258, RECRUITING
- Reduce early morning movement limitations, NCT07422675, PHASE1, RECRUITING
- Stabilize movement reduce off periods, NCT06919822, RECRUITING
- Decrease hours when medications stop, NCT07313176, RECRUITING
- Reduce off time and fluctuations, NCT07219927, RECRUITING
- Find right on demand dose, NCT07145190, RECRUITING
- Steady infusion reduces off periods, NCT06937034, RECRUITING
- Link hormones with motor fluctuations, NCT06582212, RECRUITING
- Increase daily good on time, NCT07138560, PHASE4, RECRUITING
- Gene therapy reduces movement fluctuations, NCT06285643, PHASE2, RECRUITING
- Continuous medication reduces motor fluctuations, NCT06916507, RECRUITING
- Restore dopamine producing brain cells, NCT07080775, PHASE1, RECRUITING
- Reduce predictable wearing off periods, NCT06765668, PHASE4, RECRUITING
- Reduce daily off medication time, NCT06944522, PHASE3, RECRUITING
- Reduce tremor and movement fluctuations, NCT07166757, PHASE1, PHASE2, RECRUITING
- Reduce tremor and involuntary movements, NCT05626608, RECRUITING
- Identify signals predicting mood fluctuations, NCT07404241, RECRUITING
- Reduce medication wearing off fluctuations, NCT06928519, RECRUITING
- Nasal spray reduces off episodes, NCT07156773, PHASE2, RECRUITING
- Continuous infusion reduces wearing off, NCT06965374, RECRUITING