---
title: "Clinical Trials for OFF Time in Parkinson's | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials studying OFF time, wearing off, and motor fluctuations. See enrolling studies and get notified of new trials."
canonical_url: "https://parkinsonspathways.com/trials/symptom/off-time"
topic_type: symptom
source: "Parkinson's Pathways"
---
# Clinical Trials for OFF Time and Motor Fluctuations

OFF time is when Parkinson's medication wears off before the next dose and symptoms return. Over the years the window of good control can narrow, and some people experience unpredictable swings between ON and OFF that are hard to manage with timing alone.

Trials here test new medications, longer-lasting or steadier levodopa formulations, on-demand rescue treatments for sudden OFF episodes, and devices that deliver medication more consistently.

Below are the recruiting trials we track that focus on OFF time and motor fluctuations. Sign up to be emailed when a new one opens.

## 37 recruiting trials

- [Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.](https://parkinsonspathways.com/trial/NCT07398157) — Personalize brain stimulation for movement
- [Multicenter Study of Safety and Effectiveness of Auricular Muscle Zone Stimulation With the EarStim Novel Device for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07400731) — Relieve movement symptoms between doses
- [Observational Prospective Study to Evaluate Effectiveness of Subcutaneous Treatment With Foslevodopa/Foscarbidopa in Real Life Setting for Advanced Parkinson's Disease Patients in Belgium.](https://parkinsonspathways.com/trial/NCT07382440) — Reduce off time with infusion
- [Phase 2, Double-blind, Placebo-controlled Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations](https://parkinsonspathways.com/trial/NCT07432958) — Reduce wearing off between doses
- [The Effect of Motor Imagery Added to Conventional Rehabilitation on Balance and Kinesiophobia in Patients With Parkinson's Disease: A Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07495462) — Improve balance through mental rehearsal
- [A Natural History Study of Treated Parkinson's Disease Patients Experiencing Motor Complications](https://parkinsonspathways.com/trial/NCT07330258) — Document motor complications despite medication
- [A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Feasibility, and Preliminary Efficacy of NouvNeu001 in Patients With Advanced Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT07102342) — Cell transplant improves motor symptoms
- [A Randomized, Placebo-Controlled, Single Ascending Dose (SAD) Study to Assess the Safety, Tolerability, and Pharmacokinetics of SER-252 in Patients With Parkinson's Disease and Motor Fluctuations](https://parkinsonspathways.com/trial/NCT07422675) — Shorten daily periods without movement
- [Somato-cognitive Action Network Targeted Epidural Modulation for Parkinson's Disease (STEM-PD): a Prospective Open-label Clinical Trial](https://parkinsonspathways.com/trial/NCT06919822) — Stabilize movement reduce off periods
- [A Prospective, Non-Interventional Study on the Long-term Effectiveness of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIGON®) in Patients With Parkinson's Disease Previously Treated With Subcutaneous Foslevodopa in Routine Care](https://parkinsonspathways.com/trial/NCT07313176) — Intestinal pump reduces involuntary movements
- [Real-life, Observational Study on Opicapone in Patients With Parkinson's Disease and Early Motor Fluctuations in Italy](https://parkinsonspathways.com/trial/NCT07403799) — Reduce wearing off motor fluctuations
- [Real-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States: A Prospective, Phase 4, Multicenter, Observational Study in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07219927) — Reduce off time and fluctuations
- [Phase I Trial of Autologous Induced Pluripotent Stem Cell-derived Dopaminergic Progenitor Cell Transplantation for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06687837) — Cell implant reduces off time
- [SL-APO in the Treatment of Patients With Parkinson's Disease: a Real-world Evidence Study to Identify Titration and Usage Schemes - SL-START](https://parkinsonspathways.com/trial/NCT07145190) — Map rescue medication dosing patterns
- [Observational Retrospective CoHort Study on Practical ExperienceS of Treatment With Foslevodopa/foScaRbidopa in Advanced Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06937034) — Steady infusion reduces off periods
- [Enabling Women with Parkinson's Disease to Identify and Better Manage Hormonal Triggers](https://parkinsonspathways.com/trial/NCT06582212) — Link hormones with motor fluctuations
- [A Clinical Trial of Parkinson's Disease Treatment by Human-induced Pluripotent Stem Cells (hiPSCs) Derived Dopaminergic Neural Precursor Cells](https://parkinsonspathways.com/trial/NCT06145711) — Reduce medication wearing off symptoms
- [BOOST-PD - Better On-time Observations of Motor Fluctuations Using Wearable Sensor Technology: A Naturalistic Study on IPX-203 for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07138560) — Increase daily steady on time
- [Parkinson's Disease Rehabilitation Using Neurofeedback With Functional Electrical Stimulation and Virtual Reality Feedback for Lower Extremities](https://parkinsonspathways.com/trial/NCT06690931) — Improve walking and leg function
- [A Phase 2, Randomized, Double-blind, Sham Surgery-controlled Study of the Efficacy and Safety of Intraputaminal AAV2-GDNF in the Treatment of Adults With Moderate Stage Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06285643) — Gene therapy reduces movement fluctuations
- [German Real-World Evidence Study on the Effectiveness of Foslevodopa/Foscarbidopa at Initial Stages of Advanced Parkinson's Disease: Motor Symptoms, Quality of Life, Psychosocial Functioning and Work Ability](https://parkinsonspathways.com/trial/NCT06916507) — Continuous medication reduces motor fluctuations
- [Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation](https://parkinsonspathways.com/trial/NCT06951906) — Predict brain stimulation easing freezing
- [A Phase I Clinical Study on the Safety and Tolerability of iPSC-Derived Dopaminergic Neural Progenitor Cell Injection Via Stereotaxic Brain Transplantation for the Treatment of Primary Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07080775) — Cell transplant reduces off time
- [A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications](https://parkinsonspathways.com/trial/NCT05539196) — Reduce medication refractory motor complications
- [Open-Label Phase 4 Study of CREXONT® (Carbidopa and Levodopa) Extended Release Capsules in Parkinson's Disease Patients](https://parkinsonspathways.com/trial/NCT06765668) — Reduce predictable wearing off periods
- [exPDite-2: A Phase 3 Study to Assess the Efficacy and Safety of Midbrain Dopaminergic Neuronal Cell Therapy (Bemdaneprocel) for Participants With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06944522) — Reduce daily off medication time
- [Observational Study Evaluating Subcutaneous LDp/CDp Solution for Infusion Effectiveness on Sleep Disturbances in Advanced Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07284342) — Steady medication infusion improves sleep
- [A Phase I/II Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of Human Allogeneic Induced Pluripotent Stem Cell-derived Dopaminergic Neural Progenitor Cell Injection in the Treatment of Early-onset Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07166757) — Reduce off period motor fluctuations
- [Deep Brain Stimulation Therapy in Movement Disorders](https://parkinsonspathways.com/trial/NCT02119611) — Brain stimulation reduces disabling tremor
- [Neuromodulation électrique Continue du Globus Pallidus Dans la Maladie de Parkinson Par l'électrode Directionnelle CARTESIA™](https://parkinsonspathways.com/trial/NCT05626608) — Reduce tremor and involuntary movements
- [Subthalamic and Cortical Electrophysiological Correlates of Motor and Neuropsychiatric Fluctuations in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07404241) — Reduce motor and neuropsychiatric fluctuations
- [Efficacy and Safety of Entacapone Combined With Madopar in the Treatment of Early Parkinson's Disease: An Observational, Multicenter, Case-Control Study](https://parkinsonspathways.com/trial/NCT06928519) — Reduce medication wearing off fluctuations
- [Study on Safety and Clinical Efficacy of XJN010 Nasal Spray in Patients With Parkinson's Disease Experiencing Off Episodes](https://parkinsonspathways.com/trial/NCT07156773) — Nasal spray reduces off episodes
- [A Randomized, Controlled, Double-blind, Double-dummy, Multicenter Phase III Study to Evaluate the Efficacy and Safety of HRG2010 in Parkinson's Disease With Motor Fluctuations](https://parkinsonspathways.com/trial/NCT06596876) — Reduce predictable off time episodes
- [Role of the Subthalamic Nucleus in the Control of Movement: Physiopathology of Akinesia in Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT01682668) — Brain stimulation reduces movement fluctuations
- [Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD](https://parkinsonspathways.com/trial/NCT06169852) — Reduce tremor stiffness and slowness
- [Foslevodopa/Foscarbidopa REal-world Evidence in Parkinson's Disease Quality of LIFE Outcomes](https://parkinsonspathways.com/trial/NCT06965374) — Continuous infusion reduces wearing off

## Related topics

- [Dyskinesia](https://parkinsonspathways.com/trials/symptom/dyskinesia)
- [Semaglutide](https://parkinsonspathways.com/trials/drug/semaglutide)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)