---
title: "Clinical Trials for Parkinson's Sleep Problems | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials studying sleep, REM sleep behavior disorder, insomnia, and daytime sleepiness. See enrolling studies and get an email when a new sleep trial opens."
canonical_url: "https://parkinsonspathways.com/trials/symptom/sleep"
topic_type: symptom
source: "Parkinson's Pathways"
---
# Clinical Trials for Parkinson's Sleep Problems

Sleep problems are one of the most common and least talked-about parts of Parkinson's. Insomnia, REM sleep behavior disorder, restless legs, and excessive daytime sleepiness all show up frequently, and they meaningfully affect quality of life.

Trials in this area study new medications for daytime sleepiness, treatments for REM sleep behavior disorder, and observational studies that track sleep changes over time. REM sleep behavior disorder is also one of the most studied early warning signs for Parkinson's, so some prevention-focused trials specifically recruit people with this condition.

Below are the recruiting trials we track that focus on sleep. Sign up to be emailed when a new one opens.

## 45 recruiting trials

- [Exploration of the Reward System in Parkinson's Patients With Paradoxical Sleep Behavior Disorders: a Multimodal Imaging Study](https://parkinsonspathways.com/trial/NCT07213219), Predict impulse control from scans
- [THE EFFECT OF L-THEANINE SUPPLEMENTATION ON REM SLEEP BEHAVIOR DISORDER, GASTROINTESTINAL FUNCTION, AND INFLAMMATORY MARKERS IN PARKINSON'S DISEASE](https://parkinsonspathways.com/trial/NCT07682532), Reduce acting out dreams nightly
- [Effects of Osteopathic Manipulative Treatment Protocol on Sleep Quality in Parkinson's Disease Subjects](https://parkinsonspathways.com/trial/NCT06671600), Can osteopathic treatment improve sleep
- [Sensing in Sleep and Deep Brain Stimulation](https://parkinsonspathways.com/trial/NCT07636720), Does stimulation change sleep quality
- [Adaptive vs Conventional Deep Brain Stimulation for Parkinson's Disease: A Multi-center Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07635823), Increase time without involuntary movements
- [PARKINSON BRASIL - Database on Motor and Non-Motor Aspects of Parkinson's Disease in Brazil](https://parkinsonspathways.com/trial/NCT06536348), Map movement mood and sleep
- [Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.](https://parkinsonspathways.com/trial/NCT07398157), Personalize brain stimulation for movement
- [Non-pharmacological Enhancement of Deep Sleep With Auditory Stimulation Versus Sham in People With Parkinson's Disease and Mild Cognitive Impairment Receiving Cognitive Training: A Double-blind Randomized Trial (PD-CogT-Sleep)](https://parkinsonspathways.com/trial/NCT07441915), Improve deep sleep and thinking
- [BioFINDER-Sleep: Idiopathic REM-sleep Behavior Disorder & Early Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07533799), Predict who will develop Parkinson
- [Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial](https://parkinsonspathways.com/trial/NCT07478146), Does aerobic training improve walking
- [Ultra-High Resolution PET of the Human Brain and Spinal Cord in Healthy Aging, Dementia, Movement Disorders, ALS and Psychotic Disorders](https://parkinsonspathways.com/trial/NCT07509125), Distinguish Parkinson from related disorders
- [Implementing a National Biobank of Genetic, Sporadic and Prodromic Parkinson's Disease With Whole Genome Analysis and Functional Assessment of Polygenic Inheritance by iPSC Technology](https://parkinsonspathways.com/trial/NCT05721911), Identify rare genes causing Parkinsons
- [Adapting High-Intensity Exercise and Sleep Monitoring Technology for Home Use in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07498296), Build strength and improve walking
- [The Relationship Between Balance and Gait Impairments, Physical Activity Level, and Sleep Quality in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07424924), Determine how balance affects sleep
- [Neural Mechanisms and Clinical Applications of Deep Brain Stimulation for Modulating Sleep Dysregulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06914466), Improve sleep with brain stimulation
- [Evaluating the Effect of Mirtazapine on Anxiety in Parkinson's Disease Patients; a Randomized Double-blinded Placebo-controlled Clinical Trial](https://parkinsonspathways.com/trial/NCT06530290), Reduce anxiety symptoms with mirtazapine
- [The Impact of a Digital System on the Monitoring and Self-management of Non-motor Symptoms in People With Parkinson's](https://parkinsonspathways.com/trial/NCT07038486), Improve selfmanagement for nonmotor symptoms
- [Esketamine in Microelectrode Recording-guided Subthalamic Deep-Brain Stimulation for Parkinson's Disease（ASPIRE）：A Randomized Controlled, Double-blind Study](https://parkinsonspathways.com/trial/NCT06543563), Preserve brain signals during surgery
- [Effects of Propofol on Brain Function in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05895019), Assess propofol effects on brain
- [Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease](https://parkinsonspathways.com/trial/NCT03019757), Differentiate dementias using brain imaging
- [Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers in Sleep Dysregulation and Repair](https://parkinsonspathways.com/trial/NCT05070013), Reduce nighttime awakenings with stimulation
- [Artificial Intelligence on Molecular Imaging to Predict the Risks of Parkinson's Disease for Patients With Rapid Eye Movement Sleep Behavior Disorder](https://parkinsonspathways.com/trial/NCT06629207), Predict Parkinson risk using imaging
- [The Chinese Parkinson's Disease With SNCA Variants Registry](https://parkinsonspathways.com/trial/NCT03523052), Describe symptoms and blood tests
- [Study of the Progression of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Patients With Parkinson's Disease Divided Into Brain-first and Body-first Phenotypes](https://parkinsonspathways.com/trial/NCT07187843), Predict balance and thinking changes
- [Overnight Treatment of Parkinson's Disease Using Vestibular Stimulation From a Rocking Bed (Somnomat Casa) - A Feasibility Study](https://parkinsonspathways.com/trial/NCT06386497), Improve sleep using vestibular stimulation
- [Observational Case Series of Patients With Parkinson's Disease (PD) Attending a Complementary Medicine Neuro-degenerative Disease (NDD) Clinic.](https://parkinsonspathways.com/trial/NCT07207096), Complementary medicine to reduce stiffness
- [Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease (CHAMPION)：A Randomized Controlled, Non-Inferiority Study](https://parkinsonspathways.com/trial/NCT05550714), Confirm tremor control under anesthesia
- [Understanding Motivation in Parkinson's Patients Through Neurophysiology](https://parkinsonspathways.com/trial/NCT05065151), Brain stimulation improves daily motivation
- [Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease - The DREAMS-PD Study](https://parkinsonspathways.com/trial/NCT07110376), Nighttime brain stimulation improves sleep
- [Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity](https://parkinsonspathways.com/trial/NCT07324330), Slow thinking decline via activity
- [Remote Monitoring Using Commercially Available Activity Trackers and Computer Vision Provides a Holistic, Low-cost Assessment of Parkinson's Disease Symptoms](https://parkinsonspathways.com/trial/NCT06573762), Monitor gait and tremor remotely
- [A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis: a Single-center, Randomized, Double-blind Study](https://parkinsonspathways.com/trial/NCT06304285), Can gut acupuncture ease movement
- [Molecular Imaging of LPS-induced Microglial Activation in Parkinson's Disease (PD). A TSPO PET-MR Imaging Study](https://parkinsonspathways.com/trial/NCT05205291), Measure brain inflammation in Parkinson
- [Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands](https://parkinsonspathways.com/trial/NCT06193252), Slow Parkinson progression through exercise
- [Sleep-specific DBS Therapy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05962489), Improve sleep with brain stimulation
- [Clinical Study on the Efficacy and Safety of rTMS Regulating Slow-wave Sleep to Delay the Progression of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06002581), Can brain stimulation slow progression
- [Observational Study Evaluating Subcutaneous LDp/CDp Solution for Infusion Effectiveness on Sleep Disturbances in Advanced Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07284342), Improve sleep with skin infusion
- [Light Therapy in Parkinson's Disease: a Prospective, Observational Study](https://parkinsonspathways.com/trial/NCT06129942), Improve sleep with bright light
- [Prevalence and Characteristics of Restless Leg Syndrome in Thai Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06684782), Measure restless leg syndrome prevalence
- [Cohort of the French Clinical Research Network for Parkinson's Disease (NS-PARK Cohort)](https://parkinsonspathways.com/trial/NCT04888364), Help slow Parkinson disease progression
- [Biochemical Characterization of Parkinson's Disease-related Proteins in the Enteric Nervous System as a Proxy for Pathological Changes in the Brain](https://parkinsonspathways.com/trial/NCT05347407), Early Parkinsons detection from gut
- [The Effects of Different Exercise Modalities on Sleep Quality and Architecture in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05644327), Improve sleep quality through exercise
- [Stimulation of the External Pallidal Segment for Insomnia in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04116996), Improve insomnia with pallidal stimulation
- [Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving Rapid Eye Movement Behavior Disorder with Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06710574), Probiotics reduce acting out dreams
- [Detection of Phosphorylated Alpha-Synuclein in Colonic Tissue Biopsy During Routine Colonoscopy](https://parkinsonspathways.com/trial/NCT07217054), Detect Parkinson using colon samples

## Related topics

- [Depression & Anxiety](https://parkinsonspathways.com/trials/symptom/depression-anxiety)
- [Cognition & Memory](https://parkinsonspathways.com/trials/symptom/cognition)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)