---
title: "Clinical Trials for Parkinson's Tremor | Parkinson's Pathways"
description: "Recruiting Parkinson's clinical trials studying tremor. See enrolling studies testing new medications, focused ultrasound, and devices, and get notified of new trials."
canonical_url: "https://parkinsonspathways.com/trials/symptom/tremor"
topic_type: symptom
source: "Parkinson's Pathways"
---
# Clinical Trials for Parkinson's Tremor

Tremor is one of the most visible Parkinson's symptoms, and it can be one of the hardest to manage when standard medications fall short. A number of clinical trials are looking at this problem from different angles.

Some trials test new oral medications. Others look at focused ultrasound, deep brain stimulation refinements, and wearable devices that suppress tremor without surgery. A few are observational studies that track how tremor changes over time.

Below are the recruiting trials we track that focus on tremor. Sign up to be emailed when a new one opens.

## 64 recruiting trials

- [The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease: A Three-arm, Randomized, Double-blind, Parallel-controlled Study](https://parkinsonspathways.com/trial/NCT07572903) — Reduce tremor and movement stiffness
- [Transcranial Magnetic Stimulation for the Treatment of Tremo](https://parkinsonspathways.com/trial/NCT07574164) — Reduce tremor using brain stimulation
- [A Single-Center, Double-Blind Randomized Controlled Trial of Accelerated Temporal Interference Stimulation Applied to Bilateral Subthalamic Nucleus for Improving Motor and Vocal Functions in Patients With Parkinson's Disease Or Secondary Parkinson's Syndrome](https://parkinsonspathways.com/trial/NCT07568067) — Improve movement and speech function
- [Implementing a National Biobank of Genetic, Sporadic and Prodromic Parkinson's Disease With Whole Genome Analysis and Functional Assessment of Polygenic Inheritance by iPSC Technology](https://parkinsonspathways.com/trial/NCT05721911) — Identify genetic causes of Parkinson
- [Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients](https://parkinsonspathways.com/trial/NCT07384442) — Reduce tremor and improve gait
- [Assessing the Relation Between Subcortical LFPs and DBS Parameter Selection in Parkinson's Disease - a Prospective Study](https://parkinsonspathways.com/trial/NCT07485621) — Personalize stimulation to reduce tremor
- [NEUROTECHNO: Precision Medicine and Neurodegenerative Diseases: Advanced Systems for the Diagnosis and Treatment of Parkinson's Disease and Alzheimer's Disease.](https://parkinsonspathways.com/trial/NCT07467460) — Early detection slows Parkinson progression
- [Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients](https://parkinsonspathways.com/trial/NCT07455760) — Improve speech sequencing using stimulation
- [A Prospective Observational Study for the Predictors of Clinical Outcomes of Deep Brain Stimulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07376278) — Predict benefit from brain stimulation
- [Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07428447) — Predict Parkinson in essential tremor
- [Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders](https://parkinsonspathways.com/trial/NCT07417280) — Reduce tremor with focused ultrasound
- [Detection of Internal Tremors by Oscillometry in Parkinson's Patient : a Pilot Study](https://parkinsonspathways.com/trial/NCT06885541) — Detect internal tremors using oscillometry
- [Deep Brain Stimulation Surgery for Movement Disorders](https://parkinsonspathways.com/trial/NCT01581580) — Reduce tremor using Medtronic Activa
- [Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2](https://parkinsonspathways.com/trial/NCT05557864) — Reduce tremor stiffness and slowness
- [An Open Multi-centre Investigation to Evaluate the Performance of the Paragit Sleeve With build-in sEMG Sensors, Kinetic Sensors, and Smart-textile to Measure and Monitor Motor Symptoms and Treatment-induced Dyskinesia in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06490861) — Monitor involuntary movements and tremor
- [Influence of Autonomy on Motor Learning in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT05960331) — Improve upper limb motor learning
- [Closed-loop Phase-adaptive Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Activity in the Cerebello-thalamo-cortical Network to Reduce Parkinson's Disease Tremor](https://parkinsonspathways.com/trial/NCT06993571) — Timed stimulation reduces hand tremor
- [Research on the Brain Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Regulating PD Motor Symptoms](https://parkinsonspathways.com/trial/NCT06409338) — Gentle ear stimulation improves movement
- [Prospective Study of Constant Current Versus Constant Voltage Deep Brain Stimulation in Patients with Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06742450) — Steadier brain pulses reduce tremor
- [Sensory-specific Peripheral Stimulation for Tremor Management](https://parkinsonspathways.com/trial/NCT04501133) — Reduce upper limb tremor severity
- [A Randomized Controlled Trial of Bilateral Subthalamic Stimulation in Patients With Parkinson's Disease and Impulse Control Disorders](https://parkinsonspathways.com/trial/NCT06498349) — Reduce impulse control disorder behaviors
- [Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06899022) — Improve attention during brain stimulation
- [Impact of a Biophoton Therapy on Patients With Brain Disorders](https://parkinsonspathways.com/trial/NCT06147999) — Test biophoton therapy for tremor
- [The Parkinson's Disease Case-Control Study: Gut Microbiome Study for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06848192) — Link gut microbiome to tremor
- [Predictors and Mechanisms of Tremor Relapse After MR-Guided Focused Ultrasound Thalamotomy in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07284719) — Prevent tremor relapse after thalamotomy
- [Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst](https://parkinsonspathways.com/trial/NCT05658302) — Targeted brain stimulation reduces tremor
- [Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07348705) — Reduce tremor slowness and stiffness
- [A Phase I, Open Label, Single Arm, Dose Escalation and Dose Expansion Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of Human Induced Pluripotent Stem Cell Derived Dopaminergic Progenitor Cells (NCR201) Injection in the Treatment of Subjects With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06978920) — Donor cell injections reduce tremor
- [Investigating Neural Biomarkers for Gait in Parkinson's Patients](https://parkinsonspathways.com/trial/NCT05820074) — Improve gait using Percept neurostimulation
- [Investigating Inhibitory Control Networks in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04735458) — Improve ability to stop actions
- [24-months, Open-label, Single-Site Extension Study to Evaluate Safety, Tolerability and Efficacy of the Home-based Peroneal Electrical Transcutaneous NeuroModulation (Peroneal eTNM®) Treatment Via Nerve Stimulator URIS ITM in Treatment of Symptoms Related to Movement Disorders in Subjects With Parkinson's Disease (PD) and Essential Tremor (ET)](https://parkinsonspathways.com/trial/NCT06570421) — Reduce freezing episodes while walking
- [Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation](https://parkinsonspathways.com/trial/NCT06951906) — Predict brain stimulation easing freezing
- [Remote Monitoring Using Commercially Available Activity Trackers and Computer Vision Provides a Holistic, Low-cost Assessment of Parkinson's Disease Symptoms](https://parkinsonspathways.com/trial/NCT06573762) — Monitor gait and tremor remotely
- [Effects of Self-controlled Practice on Motor Learning and Motivation in People With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07028515) — Improve upper limb motor learning
- [A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis: a Single-center, Randomized, Double-blind Study](https://parkinsonspathways.com/trial/NCT06304285) — Acupuncture reduces tremor and slowness
- [Effect of Sensory Electrical Stimulation on Resting Tremors in Patients with Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06646510) — Decrease resting hand tremor electrically
- [Preparation and Feasibility of Exams for Expected Studies (PRELUDE)](https://parkinsonspathways.com/trial/NCT05698810) — Improve diagnostic imaging for tremor
- [A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04991831) — Reduce unilateral tremor with Exablate
- [Deep Brain Stimulation Therapy in Movement Disorders](https://parkinsonspathways.com/trial/NCT02119611) — Brain stimulation reduces disabling tremor
- [A Double-blind Crossover Study to Evaluate the Safety and Efficacy of Adaptive Deep Brain Stimulation Delivered Through AlphaDBS System in Patients With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04681534) — Reduce tremor slowness and stiffness
- [Neuromodulation électrique Continue du Globus Pallidus Dans la Maladie de Parkinson Par l'électrode Directionnelle CARTESIA™](https://parkinsonspathways.com/trial/NCT05626608) — Reduce tremor and involuntary movements
- [Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06692920) — Map brain signals causing tremor
- [Efficacy of Deep Brain Stimulation and Levodopa on Freezing of Gait in Advanced Parkinson's Disease: a Comparative Study](https://parkinsonspathways.com/trial/NCT06316232) — Reduce freezing episodes during walking
- [Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT04650932) — Reduce tremor while preserving speech
- [The Use of the CUE1/CUE1+ Device in People With Idiopathic Parkinson's Disease and Related Disorders: A Feasibility Study](https://parkinsonspathways.com/trial/NCT06174948) — Improve walking rhythm and balance
- [Clinical Study on Non-Invasive Fundus Retinal Detection Technology for Early Diagnosis of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT07244640) — Retinal imaging detects early Parkinson
- [Cortical Electrophysiology of Response Inhibition in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06234995) — Improve ability to stop actions
- [Evaluation and Treatment of Neurosurgical Disorders](https://parkinsonspathways.com/trial/NCT00060541) — Reduce tremor through neurosurgical evaluation
- [Natural History Protocol for Movement Disorders](https://parkinsonspathways.com/trial/NCT05413291) — Track movement disorder symptom progression
- [Acute Treatment of Parkinson's Disease With Gamma Frequency Stimulation](https://parkinsonspathways.com/trial/NCT05268887) — Reduce slowness stiffness and tremor
- [Parkinson's Foundation Surveys](https://parkinsonspathways.com/trial/NCT05066763) — Track tremor severity over time
- [rTMS as a Cognitive Rehabilitation Approach in Veterans With Parkinson's Disease](https://parkinsonspathways.com/trial/NCT03836950) — Improve cognitive function in Parkinsons
- [Mechanism and Application of Deep Brain Stimulation in the Treatment of Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06400017) — Reduce tremor and improve movement
- [Comparing the Effectiveness of Online Self-management Program and On-site Task-related Training for People With Early Stage Parkinson's Disease on Activity Participation and Quality of Life](https://parkinsonspathways.com/trial/NCT06248073) — Increase participation in daily activities
- [Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control](https://parkinsonspathways.com/trial/NCT06013956) — Reduce tremor through brain stimulation
- [Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders](https://parkinsonspathways.com/trial/NCT04061135) — Brain stimulation improves stopping movements
- [Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry](https://parkinsonspathways.com/trial/NCT02071134) — Reduce tremor stiffness and slowness
- [Virtual Remote Assessment of Transcranial Electrical Stimulation for Parkinson's Disease Motor Symptoms](https://parkinsonspathways.com/trial/NCT07182058) — Improve walking through transcranial stimulation
- [Randomized Controlled Trial Comparing Adaptive Versus Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease](https://parkinsonspathways.com/trial/NCT06909045) — Reduce tremor and movement fluctuations
- [Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD](https://parkinsonspathways.com/trial/NCT06169852) — Reduce tremor stiffness and slowness
- [Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects](https://parkinsonspathways.com/trial/NCT04735172) — Identify early striatal metabolite changes
- [Physiological Brain Atlas Development](https://parkinsonspathways.com/trial/NCT00575081) — Improve targeting for brain stimulation
- [Short- and Long-term Behavioral, Cognitive and Motor Outcomes of Frameless Deep Brain Stimulation in Patients With Parkinson's Disease: a Prospective Observational Study](https://parkinsonspathways.com/trial/NCT05752656) — Reduce tremor using brain stimulation
- [Machine Learning Analysis Of The Tapping Test And The Archimedean Spiral For The Differential Diagnosis Of Essential Tremor And Parkinson's Disease.](https://parkinsonspathways.com/trial/NCT06378619) — Distinguish essential tremor from Parkinsons

## Related topics

- [Dyskinesia](https://parkinsonspathways.com/trials/symptom/dyskinesia)
- [Balance & Falls](https://parkinsonspathways.com/trials/symptom/balance-falls)

## Related

- [Browse all recruiting trials](https://parkinsonspathways.com/trials)
- [Match yourself to relevant trials](https://parkinsonspathways.com/match)
- [Get the free Monday digest of new recruiting Parkinson's trials](https://parkinsonspathways.com/digest)