Create personalized stem cell therapies
- Trial ID
- NCT00874783
- Official Title
- Derivation of Induced Pluripotent Stem Cells from Somatic Cells Donated by Patients with Neurological Diseases for the Study of the Pathogenesis of the Disorders and Development of Novel Therapies
- Goal
- Create personalized stem cell therapies
- Status
- RECRUITING
- Sponsor
- Hadassah Medical Organization
- Study Type
- OBSERVATIONAL
- Enrollment
- 120 participants
- Conditions
- Neurodegenerative Disorders
Summary For Families
The goal is to make patient-derived stem cell models so researchers can see how neurodegenerative diseases start and help develop new therapies. Donors give a small sample of tissue or a few intact hairs, those somatic cells are reprogrammed into induced pluripotent stem cells and then turned into neurons in the lab so scientists can study disease processes and test potential drugs on cells with the patient’s own genetics. The study is looking for adults 18 and older who have a diagnosed neurodegenerative disorder and can donate tissue during a medical procedure or a few hairs, and it also accepts healthy adult donors, aiming for about 120 participants. There is no experimental treatment given to participants, and no exclusion criteria were listed.
Locations
- Hadassah Ein Kerem, Jerusalem, Israel, Israel
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The goal is to make patient-derived stem cell models so researchers can see how neurodegenerative diseases start and help develop new therapies. Donors give a small sample of tissue or a few intact hairs, those somatic cells are reprogrammed into induced pluripotent stem cells and then turned into neurons in the lab so scientists can study disease processes and test potential drugs on cells with the patient’s own genetics. The study is looking for adults 18 and older who have a diagnosed neurodegenerative disorder and can donate tissue during a medical procedure or a few hairs, and it also accepts healthy adult donors, aiming for about 120 participants. There is no experimental treatment given to participants, and no exclusion criteria were listed.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 21 years and 8 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.