Improve walking with Parkinson medication
- Trial ID
- NCT02994719
- Official Title
- Gait Pattern Analysis in Neurological Disease
- Goal
- Improve walking with Parkinson medication
- Status
- RECRUITING
- Sponsor
- Beth Israel Deaconess Medical Center
- Study Type
- OBSERVATIONAL
- Enrollment
- 120 participants
- Conditions
- Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease
- Interventions
- Anti-Parkinson medication, Deep Brain Stimulation
Summary For Families
The goal is to map how Parkinson's and related disorders change walking, and to measure how anti-Parkinson medications and deep brain stimulation alter gait compared with healthy adults. Participants have their walking recorded while on their usual anti-Parkinson meds, which raise brain dopamine to improve movement, and for those with DBS the team may compare gait with stimulation on versus off, using motion analysis and sensors to quantify stride, speed, variability, and frontal gait features. Adults 18 to 85 are eligible, including people with Parkinson's or atypical parkinsonism who have at least two cardinal motor signs and healthy controls without walking complaints, with requirements for cognitive screening, safe mobility, and exclusions for other causes of parkinsonism, recent hospitalization, serious heart or lung disease, or participation in another interventional trial.
Locations
- Clinical Research Center BIDMC, Boston, Massachusetts, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Anti-Parkinson medication. The goal is to map how Parkinson's and related disorders change walking, and to measure how anti-Parkinson medications and deep brain stimulation alter gait compared with healthy adults. Participants have their walking recorded while on their usual anti-Parkinson meds, which raise brain dopamine to improve movement, and for those with DBS the team may compare gait with stimulation on versus off, using motion analysis and sensors to quantify stride, speed, variability, and frontal gait features. Adults 18 to 85 are eligible, including people with Parkinson's or atypical parkinsonism who have at least two cardinal motor signs and healthy controls without walking complaints, with requirements for cognitive screening, safe mobility, and exclusions for other causes of parkinsonism, recent hospitalization, serious heart or lung disease, or participation in another interventional trial.
- Who can participate?
- Participants must be between 18 Years and 85 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 10 years and 4 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.