Brain stimulation improves stopping movements
- Trial ID
- NCT04061135
- Official Title
- Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders
- Goal
- Brain stimulation improves stopping movements
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Alabama at Birmingham
- Study Type
- INTERVENTIONAL
- Enrollment
- 90 participants
- Conditions
- Movement Disorders
- Interventions
- Response Inhibition and Deep Brain Stimulation in Parkinson's disease
Summary For Families
They want to map how deep brain stimulation changes the brain networks that control stopping or changing movements, like response inhibition, and how those changes relate to behavior and thinking in Parkinson's disease and essential tremor. People having DBS surgery will perform response inhibition tasks while researchers record brain activity and test how the implanted device's electrical pulses alter those signals and task performance; DBS delivers targeted electrical stimulation to deep brain regions to reduce motor symptoms and can modulate cognitive control circuits. Adults 18 and older with Parkinson's disease or essential tremor who are judged suitable for DBS surgery and can give informed consent and take part in the testing are eligible, while people who are not surgical candidates, cannot consent, are pregnant, or have not tried conservative medical management are excluded.
Locations
- University of Alabama at Birmingham, Birmingham, Alabama, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Response Inhibition and Deep Brain Stimulation in Parkinson's disease. They want to map how deep brain stimulation changes the brain networks that control stopping or changing movements, like response inhibition, and how those changes relate to behavior and thinking in Parkinson's disease and essential tremor. People having DBS surgery will perform response inhibition tasks while researchers record brain activity and test how the implanted device's electrical pulses alter those signals and task performance; DBS delivers targeted electrical stimulation to deep brain regions to reduce motor symptoms and can modulate cognitive control circuits. Adults 18 and older with Parkinson's disease or essential tremor who are judged suitable for DBS surgery and can give informed consent and take part in the testing are eligible, while people who are not surgical candidates, cannot consent, are pregnant, or have not tried conservative medical management are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 8 years and 7 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.