Boost brain energetics using exercise
- Trial ID
- NCT04426786
- Official Title
- The Effect of Exercise on Brain Energetics in Parkinson's Disease
- Goal
- Boost brain energetics using exercise
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Pacific Parkinson's Research Centre
- Study Type
- INTERVENTIONAL
- Enrollment
- 40 participants
- Conditions
- Parkinson Disease
- Interventions
- Active exercise, Passive exercise
Plain-Language Summary
The goal is to see whether regular exercise can boost brain energy metabolism in people with mild to moderate Parkinson's, which might help movement and thinking by improving how brain cells make and use energy. Participants do either active exercise, a supervised aerobic program meant to raise heart rate, increase blood flow, and stimulate mitochondrial energy production in the brain, or passive exercise where limbs are moved without active exertion, and changes in brain energetics are tracked with MRI and other tests; the program includes about 72 classes with a goal of completing at least 60. The trial is looking for people aged 40 to 80 with idiopathic Parkinson's at Hoehn and Yahr stages I to III who currently exercise less than 120 minutes per week, can tolerate being off Parkinson's meds for up to 24 hours, are medically cleared for aerobic testing, and do not have major medical, psychiatric, or MRI contraindications.
Locations
- Pacific Parkinson's Research Centre, Vancouver, British Columbia, Canada
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Active exercise. The goal is to see whether regular exercise can boost brain energy metabolism in people with mild to moderate Parkinson's, which might help movement and thinking by improving how brain cells make and use energy. Participants do either active exercise, a supervised aerobic program meant to raise heart rate, increase blood flow, and stimulate mitochondrial energy production in the brain, or passive exercise where limbs are moved without active exertion, and changes in brain energetics are tracked with MRI and other tests; the program includes about 72 classes with a goal of completing at least 60. The trial is looking for people aged 40 to 80 with idiopathic Parkinson's at Hoehn and Yahr stages I to III who currently exercise less than 120 minutes per week, can tolerate being off Parkinson's meds for up to 24 hours, are medically cleared for aerobic testing, and do not have major medical, psychiatric, or MRI contraindications.
- Who can participate?
- Participants must be between 40 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 4 years and 11 months.