Active exercise for Parkinson's (NCT04426786)
Boost brain energetics using exercise
- Trial ID
- NCT04426786
- Official Title
- The Effect of Exercise on Brain Energetics in Parkinson's Disease
- Goal
- Boost brain energetics using exercise
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Pacific Parkinson's Research Centre
- Study Type
- INTERVENTIONAL
- Enrollment
- 40 participants
- Conditions
- Parkinson Disease
- Interventions
- Active exercise, Passive exercise
Summary For Families
The goal is to see whether regular exercise can boost brain energy metabolism in people with mild to moderate Parkinson's, which might help movement and thinking by improving how brain cells make and use energy. Participants do either active exercise, a supervised aerobic program meant to raise heart rate, increase blood flow, and stimulate mitochondrial energy production in the brain, or passive exercise where limbs are moved without active exertion, and changes in brain energetics are tracked with MRI and other tests; the program includes about 72 classes with a goal of completing at least 60. The trial is looking for people aged 40 to 80 with idiopathic Parkinson's at Hoehn and Yahr stages I to III who currently exercise less than 120 minutes per week, can tolerate being off Parkinson's meds for up to 24 hours, are medically cleared for aerobic testing, and do not have major medical, psychiatric, or MRI contraindications.
Locations
- Pacific Parkinson's Research Centre, Vancouver, British Columbia, Canada
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Active exercise. The goal is to see whether regular exercise can boost brain energy metabolism in people with mild to moderate Parkinson's, which might help movement and thinking by improving how brain cells make and use energy. Participants do either active exercise, a supervised aerobic program meant to raise heart rate, increase blood flow, and stimulate mitochondrial energy production in the brain, or passive exercise where limbs are moved without active exertion, and changes in brain energetics are tracked with MRI and other tests; the program includes about 72 classes with a goal of completing at least 60. The trial is looking for people aged 40 to 80 with idiopathic Parkinson's at Hoehn and Yahr stages I to III who currently exercise less than 120 minutes per week, can tolerate being off Parkinson's meds for up to 24 hours, are medically cleared for aerobic testing, and do not have major medical, psychiatric, or MRI contraindications.
- Who can participate?
- Participants must be between 40 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 4 years and 11 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This trial has 2 groups, and 1 is a placebo group. Because assignment is random, you have about a 1 in 2 chance (roughly 50%) of being in the placebo group, assuming the groups are filled equally. Ask the coordinator to confirm the exact assignment ratio.
- How many visits does this trial involve?
- Up to 30 PD non-exercisers will have PET/MRI scans before and after a supervised six month exercise program; up to 10 habitual-exerciser PD subjects will be scanned once; and up to 30 healthy controls will be scanned once for baseline comparison.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: PET scan (minimally invasive); MRI scan (non-invasive). Confirm the full schedule with the study coordinator.