Reduce upper limb tremor severity
- Trial ID
- NCT04501133
- Official Title
- Sensory-specific Peripheral Stimulation for Tremor Management
- Goal
- Reduce upper limb tremor severity
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Shirley Ryan AbilityLab
- Study Type
- INTERVENTIONAL
- Enrollment
- 180 participants
- Conditions
- Parkinson's Disease, Essential Tremor
- Interventions
- Peripheral electrical stimulation, Single pulse TMS
Plain-Language Summary
The goal is to reduce troublesome arm tremor in Parkinson's disease and essential tremor by changing the sensory input that helps drive the shaking. The approach uses brief electrical pulses to sensory nerves in the affected limb, aiming to reset sensorimotor circuits and dampen tremor, while single-pulse transcranial magnetic stimulation is used noninvasively to measure how the brain's motor pathways respond. The trial enrolls adults 18 to 80, including people with physician-diagnosed PD or ET who have moderate to severe upper-limb tremor, plus healthy volunteers for comparison; key exclusions include implanted metal or pacemakers, a history of seizures, pregnancy, severe psychiatric or neurological disease, or inability to withhold tremor medications on the day of testing. About 180 people are expected to take part.
Locations
- Shirley Ryan AbilityLab, Chicago, Illinois, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Peripheral electrical stimulation. The goal is to reduce troublesome arm tremor in Parkinson's disease and essential tremor by changing the sensory input that helps drive the shaking. The approach uses brief electrical pulses to sensory nerves in the affected limb, aiming to reset sensorimotor circuits and dampen tremor, while single-pulse transcranial magnetic stimulation is used noninvasively to measure how the brain's motor pathways respond. The trial enrolls adults 18 to 80, including people with physician-diagnosed PD or ET who have moderate to severe upper-limb tremor, plus healthy volunteers for comparison; key exclusions include implanted metal or pacemakers, a history of seizures, pregnancy, severe psychiatric or neurological disease, or inability to withhold tremor medications on the day of testing. About 180 people are expected to take part.
- Who can participate?
- Participants must be between 18 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 5 years and 3 months.