Improve cognition through caudate stimulation
- Trial ID
- NCT04715984
- Official Title
- Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment
- Goal
- Improve cognition through caudate stimulation
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Vanderbilt University Medical Center
- Study Type
- INTERVENTIONAL
- Enrollment
- 75 participants
- Conditions
- Parkinson Disease
- Interventions
- Neurophysiology recordings, Neural stimulation
Plain-Language Summary
The team wants to map how communication between the cortex and the caudate contributes to the thinking and memory problems some people with Parkinson's experience. During awake deep brain stimulation surgery at Vanderbilt, researchers will record electrical activity from the caudate and nearby cortex and deliver brief, controlled stimulation through the planned DBS electrode while you do simple cognitive tests, to see how those circuits respond. They are enrolling adults 40 and older with Parkinson's who are scheduled for DBS under local anesthesia with a clinical electrode trajectory that contacts the caudate, and who can participate in intraoperative testing and speak English. People under 40, those who cannot follow instructions during surgery, or those with a different movement disorder are not eligible.
Locations
- Vanderbilt University Medical Center, Nashville, Tennessee, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Neurophysiology recordings. The team wants to map how communication between the cortex and the caudate contributes to the thinking and memory problems some people with Parkinson's experience. During awake deep brain stimulation surgery at Vanderbilt, researchers will record electrical activity from the caudate and nearby cortex and deliver brief, controlled stimulation through the planned DBS electrode while you do simple cognitive tests, to see how those circuits respond. They are enrolling adults 40 and older with Parkinson's who are scheduled for DBS under local anesthesia with a clinical electrode trajectory that contacts the caudate, and who can participate in intraoperative testing and speak English. People under 40, those who cannot follow instructions during surgery, or those with a different movement disorder are not eligible.
- Who can participate?
- Participants must be at least 40 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 8 years and 2 months.