Detect Parkinson protein changes early
- Trial ID
- NCT04724941
- Official Title
- Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study
- Goal
- Detect Parkinson protein changes early
- Status
- RECRUITING
- Sponsor
- University Hospital Schleswig-Holstein
- Study Type
- OBSERVATIONAL
- Enrollment
- 2000 participants
- Conditions
- Parkinson Disease
- Interventions
- No intervention
Plain-Language Summary
The goal is to detect abnormal alpha-synuclein in people before they have clear Parkinson's symptoms, so researchers can identify biological signs of prodromal disease earlier. The approach is observational screening, collecting clinical measures and biological samples to look for alpha-synuclein biomarkers, with a lumbar puncture substudy that analyzes cerebrospinal fluid for misfolded alpha-synuclein, and no experimental treatments are given. The study plans to enroll up to 2000 adults aged 50 to 99 who do not have clinical Parkinson's. People with other significant neurologic or orthopedic conditions that affect motor assessment are excluded, and anyone with contraindications to lumbar puncture or on anticoagulants cannot participate in that substudy.
Locations
- Department for Neurology, University of Kiel, Kiel, Germany
Frequently Asked Questions
- What is this trial testing?
- This trial is studying No intervention. The goal is to detect abnormal alpha-synuclein in people before they have clear Parkinson's symptoms, so researchers can identify biological signs of prodromal disease earlier. The approach is observational screening, collecting clinical measures and biological samples to look for alpha-synuclein biomarkers, with a lumbar puncture substudy that analyzes cerebrospinal fluid for misfolded alpha-synuclein, and no experimental treatments are given. The study plans to enroll up to 2000 adults aged 50 to 99 who do not have clinical Parkinson's. People with other significant neurologic or orthopedic conditions that affect motor assessment are excluded, and anyone with contraindications to lumbar puncture or on anticoagulants cannot participate in that substudy.
- Who can participate?
- Participants must be between 50 Years and 99 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 6 years and 6 months.