Improve ability to stop actions
- Trial ID
- NCT04735458
- Official Title
- Investigating Inhibitory Control Networks in Parkinson's Disease
- Goal
- Improve ability to stop actions
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Alabama at Birmingham
- Study Type
- INTERVENTIONAL
- Enrollment
- 140 participants
- Conditions
- Parkinson Disease
- Interventions
- Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
Plain-Language Summary
The goal is to map and modulate the brain circuits that let you stop or control movements, so researchers can better understand why people with Parkinson's have trouble with response inhibition and impulsive actions. The approach uses deep brain stimulation, implanting electrodes to deliver targeted electrical pulses while participants do behavioral stopping tasks and have brain signals recorded, so the team can see how DBS changes the neural activity that halts actions; DBS alters abnormal circuit activity and can also change how symptoms respond to levodopa, sometimes allowing medication adjustments. The study is looking for adults 18 and older who are judged eligible for movement‑disorder surgery with Parkinson's disease, essential tremor, or another medically‑refractory movement disorder and who can give informed consent and participate in the protocol. People with prior stroke, brain hemorrhage, seizures, or who cannot complete study activities are excluded.
Locations
- University of Alabama at Birmingham, Birmingham, Alabama, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease. The goal is to map and modulate the brain circuits that let you stop or control movements, so researchers can better understand why people with Parkinson's have trouble with response inhibition and impulsive actions. The approach uses deep brain stimulation, implanting electrodes to deliver targeted electrical pulses while participants do behavioral stopping tasks and have brain signals recorded, so the team can see how DBS changes the neural activity that halts actions; DBS alters abnormal circuit activity and can also change how symptoms respond to levodopa, sometimes allowing medication adjustments. The study is looking for adults 18 and older who are judged eligible for movement‑disorder surgery with Parkinson's disease, essential tremor, or another medically‑refractory movement disorder and who can give informed consent and participate in the protocol. People with prior stroke, brain hemorrhage, seizures, or who cannot complete study activities are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 6 years.