Improve cognition via resistance training
- Trial ID
- NCT04796506
- Official Title
- Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in Parkinson's Disease R01 HD100670
- Goal
- Improve cognition via resistance training
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Colorado, Denver
- Study Type
- INTERVENTIONAL
- Enrollment
- 120 participants
- Conditions
- Parkinson Disease
- Interventions
- Progressive Resistance Training (PRT), Delayed Exercise Training (DE), Endurance Training (ET)
Plain-Language Summary
They want to know whether targeted exercise can improve thinking and memory in people with mid-stage Parkinson's, and whether increases in slow wave sleep, the deep sleep that helps consolidate memories, can serve as a measurable sign of those brain changes. Participants are randomized to progressive resistance training, aerobic endurance training, or a delayed-exercise group; strength training builds muscle and motor control and promotes brain plasticity, while aerobic training raises heart rate and cardiorespiratory fitness and can deepen slow wave sleep, and the study tracks sleep and cognitive tests to link sleep changes with cognitive benefit. The trial seeks people aged 45 and older with idiopathic PD at Hoehn and Yahr stage 2 or 3, mild cognitive impairment range on the MoCA (scores 18 to 25), on stable medications and able to safely exercise, and excludes those with deep brain stimulation, untreated sleep apnea, regular exercise habits, significant heart or lung disease, or signs of atypical Parkinsonism.
Locations
- University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Progressive Resistance Training (PRT). They want to know whether targeted exercise can improve thinking and memory in people with mid-stage Parkinson's, and whether increases in slow wave sleep, the deep sleep that helps consolidate memories, can serve as a measurable sign of those brain changes. Participants are randomized to progressive resistance training, aerobic endurance training, or a delayed-exercise group; strength training builds muscle and motor control and promotes brain plasticity, while aerobic training raises heart rate and cardiorespiratory fitness and can deepen slow wave sleep, and the study tracks sleep and cognitive tests to link sleep changes with cognitive benefit. The trial seeks people aged 45 and older with idiopathic PD at Hoehn and Yahr stage 2 or 3, mild cognitive impairment range on the MoCA (scores 18 to 25), on stable medications and able to safely exercise, and excludes those with deep brain stimulation, untreated sleep apnea, regular exercise habits, significant heart or lung disease, or signs of atypical Parkinsonism.
- Who can participate?
- Participants must be between 45 Years and 100 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 4 years and 9 months.