Brain stimulation improves motor control
- Trial ID
- NCT04799470
- Official Title
- Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease - UNMC/Medtronic Collaborative Acute Feasibility Pilot
- Goal
- Brain stimulation improves motor control
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Nebraska
- Study Type
- INTERVENTIONAL
- Enrollment
- 10 participants
- Conditions
- Parkinson's Disease
- Interventions
- Novel DBS stimulation patterns
Plain-Language Summary
The goal is to see whether new patterns of deep brain stimulation can better target the abnormal beta brain rhythms that underlie Parkinson's motor symptoms, potentially making stimulation more precise for people already helped by DBS. The approach tests novel timing and pulse patterns delivered through your existing Medtronic Percept PC, using the Percept BrainSense survey to detect a robust beta peak (≥ 0.7 µV/rtHz) and see how changing the stimulation pattern interacts with those rhythms while you remain on your usual DBS settings and medications. Adults 19 to 80 with idiopathic Parkinson's who already have bilateral STN DBS with a Percept PC, are at least 3 months post-op with optimized meds and settings, show a good clinical response and a detectable beta peak are eligible; people with implanted cardiac devices, unstable or unusual programming needs, or a Percept flagged for replacement are excluded.
Locations
- Unversity of Nebraska Medical Center, Omaha, Nebraska, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Novel DBS stimulation patterns. The goal is to see whether new patterns of deep brain stimulation can better target the abnormal beta brain rhythms that underlie Parkinson's motor symptoms, potentially making stimulation more precise for people already helped by DBS. The approach tests novel timing and pulse patterns delivered through your existing Medtronic Percept PC, using the Percept BrainSense survey to detect a robust beta peak (≥ 0.7 µV/rtHz) and see how changing the stimulation pattern interacts with those rhythms while you remain on your usual DBS settings and medications. Adults 19 to 80 with idiopathic Parkinson's who already have bilateral STN DBS with a Percept PC, are at least 3 months post-op with optimized meds and settings, show a good clinical response and a detectable beta peak are eligible; people with implanted cardiac devices, unstable or unusual programming needs, or a Percept flagged for replacement are excluded.
- Who can participate?
- Participants must be between 19 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 4 years and 11 months.