Use spinal fluid to diagnose
- Trial ID
- NCT04844060
- Official Title
- Analysis of Clinical Data and Diagnosis in Any Person Requiring an Assay of Alzheimer Biomarkers in Cerebrospinal Fluid
- Goal
- Use spinal fluid to diagnose
- Status
- RECRUITING
- Sponsor
- University Hospital, Strasbourg, France
- Study Type
- OBSERVATIONAL
- Enrollment
- 10000 participants
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Parkinson's Disease Dementia, Multiple System Atrophy
- Interventions
- Lumbar punction
Plain-Language Summary
The goal is to see how Alzheimer-related proteins in spinal fluid relate to clinical diagnoses across different brain diseases, including Parkinson's disease dementia, so clinicians can tell which condition is most likely causing symptoms. Participants have a lumbar puncture to collect cerebrospinal fluid, which is tested for biomarkers like amyloid beta, total tau, and phosphorylated tau, and those lab results are compared with clinical information to improve diagnostic accuracy. This is an observational data-gathering effort, not a treatment, so it does not change medications like levodopa. Anyone of any age or sex who is having a lumbar puncture and has reliable clinical diagnostic information can be included.
Locations
- Service d'évaluation et Centre Mémoire de Ressources et de Recherche (CM2R), Hôpital de jour Saint François - Pôle de Gériatrie, Hôpitaux Universitaires de Strasbourg, Hôpital de la Robertsau, Strasbourg, France
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Lumbar punction. The goal is to see how Alzheimer-related proteins in spinal fluid relate to clinical diagnoses across different brain diseases, including Parkinson's disease dementia, so clinicians can tell which condition is most likely causing symptoms. Participants have a lumbar puncture to collect cerebrospinal fluid, which is tested for biomarkers like amyloid beta, total tau, and phosphorylated tau, and those lab results are compared with clinical information to improve diagnostic accuracy. This is an observational data-gathering effort, not a treatment, so it does not change medications like levodopa. Anyone of any age or sex who is having a lumbar puncture and has reliable clinical diagnostic information can be included.
- Who can participate?
- Eligibility criteria vary. Check the full listing on ClinicalTrials.gov for detailed inclusion and exclusion criteria.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 20 years and 10 months.