Stimulation on for Parkinson's (NCT05065151)
Brain stimulation improves daily motivation
- Trial ID
- NCT05065151
- Official Title
- Understanding Motivation in Parkinson's Patients Through Neurophysiology
- Goal
- Brain stimulation improves daily motivation
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of California, San Francisco
- Study Type
- INTERVENTIONAL
- Enrollment
- 70 participants
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Motivation
- Interventions
- Stimulation on, Stimulation off, Decision Making Task
Summary For Families
The goal is to learn how people with Parkinson's make motivated choices, especially how effort, reward, and deadlines affect decisions, and whether deep brain stimulation changes those motivations. Participants who already have Medtronic's Percept deep brain stimulation device will do reward-based tasks in clinic and at home that test choices for themselves and for others, while the Percept device streams brain activity and a wearable tracks movement, sleep, heart rate variability, and self-reports; everyone stays on their usual Parkinson's medicines and will do sessions with stimulation on and with stimulation off. The study measures how quickly people respond, how often they accept tasks, and how often they succeed, and also looks for brain activity patterns tied to those choices. Adults 18 and older with Parkinson's disease or dystonia who have a Percept or RC+S device implanted (at least one month after surgery) can join, provided they do not have severe thinking problems or a Montreal Cognitive Assessment score below 20, and are not pregnant.
Locations
- University of California San Francisco, San Francisco, California, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Stimulation on. The goal is to learn how people with Parkinson's make motivated choices, especially how effort, reward, and deadlines affect decisions, and whether deep brain stimulation changes those motivations. Participants who already have Medtronic's Percept deep brain stimulation device will do reward-based tasks in clinic and at home that test choices for themselves and for others, while the Percept device streams brain activity and a wearable tracks movement, sleep, heart rate variability, and self-reports; everyone stays on their usual Parkinson's medicines and will do sessions with stimulation on and with stimulation off. The study measures how quickly people respond, how often they accept tasks, and how often they succeed, and also looks for brain activity patterns tied to those choices. Adults 18 and older with Parkinson's disease or dystonia who have a Percept or RC+S device implanted (at least one month after surgery) can join, provided they do not have severe thinking problems or a Montreal Cognitive Assessment score below 20, and are not pregnant.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 9 years and 1 month.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is a crossover trial: instead of staying in one group, you move through a sequence of assignments, so you receive the active treatment during at least one period of the study. Ask the coordinator for the exact sequence and how long each phase lasts.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Questionnaires & surveys (non-invasive). Confirm the full schedule with the study coordinator.