Brain stimulation improves daily motivation
- Trial ID
- NCT05065151
- Official Title
- Understanding Motivation in Parkinson's Patients Through Neurophysiology
- Goal
- Brain stimulation improves daily motivation
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of California, San Francisco
- Study Type
- INTERVENTIONAL
- Enrollment
- 70 participants
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Motivation
- Interventions
- Stimulation on, Stimulation off, Decision Making Task
Summary For Families
The goal is to understand how deep brain stimulation changes motivation and decision-making in people with Parkinson's disease or dystonia, by linking choices to brain signals. Participants who already have a Medtronic Percept or RC+S DBS system implanted in the subthalamic nucleus (STN) or globus pallidus interna (GPi) will do decision-making tasks while researchers switch stimulation on and off and record neural activity, so we can see how the electrical pulses from DBS alter motivation-related brain circuits and behavior. The study seeks adults 18 and older who are at least one month post-DBS surgery with unilateral or bilateral Percept or RC+S implants, who do not have severe cognitive impairment (MoCA 20 or above) and are not pregnant.
Locations
- University of California San Francisco, San Francisco, California, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Stimulation on. The goal is to understand how deep brain stimulation changes motivation and decision-making in people with Parkinson's disease or dystonia, by linking choices to brain signals. Participants who already have a Medtronic Percept or RC+S DBS system implanted in the subthalamic nucleus (STN) or globus pallidus interna (GPi) will do decision-making tasks while researchers switch stimulation on and off and record neural activity, so we can see how the electrical pulses from DBS alter motivation-related brain circuits and behavior. The study seeks adults 18 and older who are at least one month post-DBS surgery with unilateral or bilateral Percept or RC+S implants, who do not have severe cognitive impairment (MoCA 20 or above) and are not pregnant.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 9 years and 1 month.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.