Neuroimaging for Parkinson's (NCT05286736)
Identify motor plasticity affecting walking
- Trial ID
- NCT05286736
- Official Title
- Plasticity of Motor Systems in Early Stage Parkinson's Disease
- Goal
- Identify motor plasticity affecting walking
- Status
- ACTIVE_NOT_RECRUITING
- Sponsor
- University of Minnesota
- Study Type
- OBSERVATIONAL
- Enrollment
- 50 participants
- Conditions
- Parkinson, Parkinson Disease
- Interventions
- Neuroimaging, Quantitative assessments
Summary For Families
Goal: Learn how motor brain circuits change in early Parkinson's, so researchers can tell whether the brain is compensating or losing plasticity in ways that affect symptoms. Approach: Participants have MRI-based neuroimaging and detailed movement testing, and some take part in transcranial magnetic stimulation sessions that send brief magnetic pulses to the motor cortex to measure how excitable and adaptable those motor pathways are, and because participants are not on levodopa or dopamine agonists at baseline, the study looks at the untreated brain's motor responses with no interaction from those drugs. Eligibility: Adults 21 to 75 with idiopathic Parkinson's diagnosed by a movement disorders neurologist who can walk 50 meters unaided, plus age- and sex-matched healthy controls. People with dementia, major psychiatric or other neurologic conditions, implanted brain or cardiac devices, pregnancy, or seizure risk are excluded, and some people excluded from the TMS portion can still join the other testing.
Locations
- University of Minnesota, Minneapolis, Minnesota, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Neuroimaging. Goal: Learn how motor brain circuits change in early Parkinson's, so researchers can tell whether the brain is compensating or losing plasticity in ways that affect symptoms. Approach: Participants have MRI-based neuroimaging and detailed movement testing, and some take part in transcranial magnetic stimulation sessions that send brief magnetic pulses to the motor cortex to measure how excitable and adaptable those motor pathways are, and because participants are not on levodopa or dopamine agonists at baseline, the study looks at the untreated brain's motor responses with no interaction from those drugs. Eligibility: Adults 21 to 75 with idiopathic Parkinson's diagnosed by a movement disorders neurologist who can walk 50 meters unaided, plus age- and sex-matched healthy controls. People with dementia, major psychiatric or other neurologic conditions, implanted brain or cardiac devices, pregnancy, or seizure risk are excluded, and some people excluded from the TMS portion can still join the other testing.
- Who can participate?
- Participants must be between 21 Years and 75 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 5 years and 6 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- How many visits does this trial involve?
- Assessments are done at baseline and again 30-36 months later (over 30-36 months).
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive); Wearable / at-home monitoring (non-invasive); Thinking & memory tests (non-invasive). Confirm the full schedule with the study coordinator.