Identify motor plasticity affecting walking
- Trial ID
- NCT05286736
- Official Title
- Plasticity of Motor Systems in Early Stage Parkinson's Disease
- Goal
- Identify motor plasticity affecting walking
- Status
- RECRUITING
- Sponsor
- University of Minnesota
- Study Type
- OBSERVATIONAL
- Enrollment
- 50 participants
- Conditions
- Parkinson, Parkinson Disease
- Interventions
- Neuroimaging, Quantitative assessments
Plain-Language Summary
Goal: Learn how motor brain circuits change in early Parkinson's, so researchers can tell whether the brain is compensating or losing plasticity in ways that affect symptoms. Approach: Participants have MRI-based neuroimaging and detailed movement testing, and some take part in transcranial magnetic stimulation sessions that send brief magnetic pulses to the motor cortex to measure how excitable and adaptable those motor pathways are, and because participants are not on levodopa or dopamine agonists at baseline, the study looks at the untreated brain's motor responses with no interaction from those drugs. Eligibility: Adults 21 to 75 with idiopathic Parkinson's diagnosed by a movement disorders neurologist who can walk 50 meters unaided, plus age- and sex-matched healthy controls. People with dementia, major psychiatric or other neurologic conditions, implanted brain or cardiac devices, pregnancy, or seizure risk are excluded, and some people excluded from the TMS portion can still join the other testing.
Locations
- University of Minnesota, Minneapolis, Minnesota, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Neuroimaging. Goal: Learn how motor brain circuits change in early Parkinson's, so researchers can tell whether the brain is compensating or losing plasticity in ways that affect symptoms. Approach: Participants have MRI-based neuroimaging and detailed movement testing, and some take part in transcranial magnetic stimulation sessions that send brief magnetic pulses to the motor cortex to measure how excitable and adaptable those motor pathways are, and because participants are not on levodopa or dopamine agonists at baseline, the study looks at the untreated brain's motor responses with no interaction from those drugs. Eligibility: Adults 21 to 75 with idiopathic Parkinson's diagnosed by a movement disorders neurologist who can walk 50 meters unaided, plus age- and sex-matched healthy controls. People with dementia, major psychiatric or other neurologic conditions, implanted brain or cardiac devices, pregnancy, or seizure risk are excluded, and some people excluded from the TMS portion can still join the other testing.
- Who can participate?
- Participants must be between 21 Years and 75 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 5 years and 4 months.