Parkinson's Trial NCT05385315
Blood test detects early Parkinson
- Trial ID
- NCT05385315
- Official Title
- Evaluation De La Performance Clinique D'un Nouveau Biomarqueur Sanguin Des Phases Précoces De La Maladie De Parkinson
- Goal
- Blood test detects early Parkinson
- Status
- RECRUITING
- Sponsor
- University Hospital, Grenoble
- Study Type
- OBSERVATIONAL
- Enrollment
- 70 participants
- Conditions
- Parkinson Disease
Summary For Families
The team is testing whether a blood biomarker made from six small molecules (acetoacetate, betaine, beta-hydroxybutyrate, creatine, pyruvate and valine) can improve early diagnosis of Parkinson's and tell Parkinson's apart from a similar condition called Multiple System Atrophy. They will measure those molecules in blood using nuclear magnetic resonance metabolomics and use a combined score that in earlier work separated newly diagnosed Parkinson's patients from healthy people with about 82.6% accuracy, and that was also seen in animal models. Adults 18 and older can join if they are newly diagnosed and not yet on Parkinson's medication, or have had Parkinson's for more than five years and are on Parkinson's medication, or have Multiple System Atrophy; people with deep brain stimulation, other neurodegenerative diseases, or certain protected groups such as pregnant or breastfeeding women and prisoners are not eligible.
Locations
- CHU Grenoble Alpes, Grenoble, France
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The team is testing whether a blood biomarker made from six small molecules (acetoacetate, betaine, beta-hydroxybutyrate, creatine, pyruvate and valine) can improve early diagnosis of Parkinson's and tell Parkinson's apart from a similar condition called Multiple System Atrophy. They will measure those molecules in blood using nuclear magnetic resonance metabolomics and use a combined score that in earlier work separated newly diagnosed Parkinson's patients from healthy people with about 82.6% accuracy, and that was also seen in animal models. Adults 18 and older can join if they are newly diagnosed and not yet on Parkinson's medication, or have had Parkinson's for more than five years and are on Parkinson's medication, or have Multiple System Atrophy; people with deep brain stimulation, other neurodegenerative diseases, or certain protected groups such as pregnant or breastfeeding women and prisoners are not eligible.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 3 years.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive). Confirm the full schedule with the study coordinator.