Improve vision guided reaching ability
- Trial ID
- NCT05400499
- Official Title
- Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease
- Goal
- Improve vision guided reaching ability
- Status
- RECRUITING
- Sponsor
- VA Office of Research and Development
- Study Type
- OBSERVATIONAL
- Enrollment
- 40 participants
- Conditions
- Parkinson's Disease
Plain-Language Summary
The project aims to learn how stimulation of the subthalamic nucleus affects visuomotor skills, meaning how well people with Parkinson's use sight to guide reaching, balance, and hand-eye coordination. Researchers will observe people who already have bilateral STN deep brain stimulation, using pre-op MRI and post-op MRI or CT to map electrode location while testing vision-guided movement; STN DBS alters abnormal firing in motor circuits and is usually used alongside levodopa, and this study keeps medications and DBS settings stable to see specific effects on visuomotor tasks. About 40 adults of any sex are being enrolled, they must have bilateral STN DBS, available pre-op MRI and ability to get post-op imaging, and be Hoehn and Yahr stage 2 to 4 off medication with stable meds and DBS settings. People with dementia, untreated major depression or anxiety, prior Parkinson's brain surgery other than DBS, or signs of atypical parkinsonism are not eligible.
Locations
- Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The project aims to learn how stimulation of the subthalamic nucleus affects visuomotor skills, meaning how well people with Parkinson's use sight to guide reaching, balance, and hand-eye coordination. Researchers will observe people who already have bilateral STN deep brain stimulation, using pre-op MRI and post-op MRI or CT to map electrode location while testing vision-guided movement; STN DBS alters abnormal firing in motor circuits and is usually used alongside levodopa, and this study keeps medications and DBS settings stable to see specific effects on visuomotor tasks. About 40 adults of any sex are being enrolled, they must have bilateral STN DBS, available pre-op MRI and ability to get post-op imaging, and be Hoehn and Yahr stage 2 to 4 off medication with stable meds and DBS settings. People with dementia, untreated major depression or anxiety, prior Parkinson's brain surgery other than DBS, or signs of atypical parkinsonism are not eligible.
- Who can participate?
- Eligibility criteria vary. Check the full listing on ClinicalTrials.gov for detailed inclusion and exclusion criteria.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 3 years and 9 months.