Auditory stimulation for Parkinson's (NCT05402488)
Boost sleep recovery with tones
- Trial ID
- NCT05402488
- Official Title
- Exploring the Recovery Function of Sleep in Neurodegeneration - an Observational Cross-Sectional Study
- Goal
- Boost sleep recovery with tones
- Phase
- NA
- Status
- UNKNOWN
- Sponsor
- University of Zurich
- Study Type
- INTERVENTIONAL
- Enrollment
- 200 participants
- Conditions
- Neurodegenerative Diseases
- Interventions
- Auditory stimulation
Summary For Families
The goal is to see whether deep, slow-wave sleep helps the brain recover from neurodegenerative diseases that involve abnormal protein build-up, and whether boosting that sleep can support protein clearance and memory. Participants wear a home EEG while gentle, timed auditory tones are played during sleep to amplify slow-wave activity, a noninvasive approach meant to strengthen sleep-dependent clearance and consolidation processes. Adults 18 and older who are either healthy or have a confirmed neurodegenerative disease with abnormal protein aggregation can join if they can use the ambulant EEG and hear the tones; people on opioids or benzodiazepines, with ear or skin issues that prevent electrode use, or who cannot follow study procedures are excluded.
Locations
- University Hospital Zurich, Neurology department, Zurich, Canton of Zurich, Switzerland
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Auditory stimulation. The goal is to see whether deep, slow-wave sleep helps the brain recover from neurodegenerative diseases that involve abnormal protein build-up, and whether boosting that sleep can support protein clearance and memory. Participants wear a home EEG while gentle, timed auditory tones are played during sleep to amplify slow-wave activity, a noninvasive approach meant to strengthen sleep-dependent clearance and consolidation processes. Adults 18 and older who are either healthy or have a confirmed neurodegenerative disease with abnormal protein aggregation can join if they can use the ambulant EEG and hear the tones; people on opioids or benzodiazepines, with ear or skin issues that prevent electrode use, or who cannot follow study procedures are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 3 years and 9 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is a crossover trial: instead of staying in one group, you move through a sequence of assignments, so you receive the active treatment during at least one period of the study. It also includes a placebo or sham phase, so you would be on that during another period. Ask the coordinator for the exact sequence and how long each phase lasts.