Prevent mania after brain stimulation
- Trial ID
- NCT05444907
- Official Title
- Understanding Deep Brain Stimulation-induced Mania: Finding Potential Predictors to Optimize Treatment
- Goal
- Prevent mania after brain stimulation
- Status
- RECRUITING
- Sponsor
- Albino Maia
- Study Type
- OBSERVATIONAL
- Enrollment
- 100 participants
- Conditions
- Mania, Parkinson Disease
- Interventions
- No Intervention / Exposure
Plain-Language Summary
The goal is to find clinical and stimulation-related factors that predict mania after deep brain stimulation, so clinicians can pick targets and programming that lower that risk. The team will compare people with Parkinson's who developed a manic or mixed affective state after the device was switched on or its settings were changed to similar DBS-treated patients who did not, looking at stimulation target and parameters, medications, and clinical history; DBS works by sending electrical pulses to specific brain areas to improve motor symptoms, but those pulses can sometimes activate nearby mood circuits and trigger mania, and it may change how much levodopa someone needs. Adults 18 and older who had DBS for Parkinson's are eligible, with one group having a post-activation or post-programming manic episode and a control group without such episodes, and anyone with bipolar disorder or a history of mania before surgery or before age 18 is excluded.
Locations
- Champalimaud Foundation, Lisbon, Portugal
Frequently Asked Questions
- What is this trial testing?
- This trial is studying No Intervention / Exposure. The goal is to find clinical and stimulation-related factors that predict mania after deep brain stimulation, so clinicians can pick targets and programming that lower that risk. The team will compare people with Parkinson's who developed a manic or mixed affective state after the device was switched on or its settings were changed to similar DBS-treated patients who did not, looking at stimulation target and parameters, medications, and clinical history; DBS works by sending electrical pulses to specific brain areas to improve motor symptoms, but those pulses can sometimes activate nearby mood circuits and trigger mania, and it may change how much levodopa someone needs. Adults 18 and older who had DBS for Parkinson's are eligible, with one group having a post-activation or post-programming manic episode and a control group without such episodes, and anyone with bipolar disorder or a history of mania before surgery or before age 18 is excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 4 years and 7 months.