Reduce on off motor swings
- Trial ID
- NCT05471609
- Official Title
- Sustained Release Oral Formulation for Treatment of Parkinson's Disease
- Goal
- Reduce on off motor swings
- Phase
- EARLY_PHASE1
- Status
- RECRUITING
- Sponsor
- University of Minnesota
- Study Type
- INTERVENTIONAL
- Enrollment
- 6 participants
- Conditions
- Healthy Volunteers
- Interventions
- levodopa/carbidopa oral formulation A, levodopa/carbidopa oral formulation B
Plain-Language Summary
Goal: test whether sustained-release oral levodopa/carbidopa can keep levodopa levels more steady, which could help reduce the on/off motor swings people with Parkinson's get with standard levodopa dosing. Approach: two experimental sustained-release formulations, A and B, are being given to healthy volunteers to look at safety and how the body absorbs and clears the drug; the pills release levodopa more slowly and include carbidopa to prevent early breakdown so more levodopa reaches the brain. Eligibility: healthy adults 18 to 65 who are not on regular medications, can fast for six hours, and are not pregnant.
Locations
- University of Minnesota, Minneapolis, Minnesota, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying levodopa/carbidopa oral formulation A. Goal: test whether sustained-release oral levodopa/carbidopa can keep levodopa levels more steady, which could help reduce the on/off motor swings people with Parkinson's get with standard levodopa dosing. Approach: two experimental sustained-release formulations, A and B, are being given to healthy volunteers to look at safety and how the body absorbs and clears the drug; the pills release levodopa more slowly and include carbidopa to prevent early breakdown so more levodopa reaches the brain. Eligibility: healthy adults 18 to 65 who are not on regular medications, can fast for six hours, and are not pregnant.
- Who can participate?
- Participants must be between 18 Years and 65 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This Phase 1 trial is estimated to last approximately 1 year.