Improve movement via sensory filtering
- Trial ID
- NCT05482126
- Official Title
- Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease
- Goal
- Improve movement via sensory filtering
- Status
- RECRUITING
- Sponsor
- University of Alabama at Birmingham
- Study Type
- OBSERVATIONAL
- Enrollment
- 30 participants
- Conditions
- Parkinson Disease
- Interventions
- Intraoperative Behavioral Testing, Behavioral Testing
Plain-Language Summary
They want to know whether the basal ganglia normally filters out irrelevant sensory signals, and if a failure of that filtering helps cause the movement and response problems seen in Parkinson's. During routine surgery to place deep brain stimulation electrodes in the subthalamic nucleus, researchers will run behavioral tests and record brain activity directly from the basal ganglia to see how neurons register or suppress sensory cues, and PD participants will be asked to withhold dopaminergic medications for at least 12 hours so recordings reflect the unmedicated state. Adults 18 and older are eligible, specifically people with advanced, idiopathic PD who have chosen STN DBS, have essentially normal pre-op brain imaging and no dementia or prior DBS, plus healthy adult controls with no neurologic disease.
Locations
- The University of Alabama at Birmingham Hospital, Birmingham, Alabama, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Intraoperative Behavioral Testing. They want to know whether the basal ganglia normally filters out irrelevant sensory signals, and if a failure of that filtering helps cause the movement and response problems seen in Parkinson's. During routine surgery to place deep brain stimulation electrodes in the subthalamic nucleus, researchers will run behavioral tests and record brain activity directly from the basal ganglia to see how neurons register or suppress sensory cues, and PD participants will be asked to withhold dopaminergic medications for at least 12 hours so recordings reflect the unmedicated state. Adults 18 and older are eligible, specifically people with advanced, idiopathic PD who have chosen STN DBS, have essentially normal pre-op brain imaging and no dementia or prior DBS, plus healthy adult controls with no neurologic disease.
- Who can participate?
- Participants must be between 18 Years and 89 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 4 years and 2 months.